Alginate/Nanohydroxyapatite Scaffolds with Designed Core/Shell Structures Fabricated by 3D Plotting and in Situ Mineralization for Bone Tissue Engineering

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

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Synthesis and Characterization of Novel Injectable, Biodegradable and In situ Crosslinkable Poly(hexamethylene-carbonate-fumarate), Poly(hexamethylene carbonate) Diacrylate and Poly(ethylene glycol fumarate-co-hexamethylene carbonate-fumarate) Scaffolds for Bone Tissue Engineering

2006 International Conference of the IEEE Engineering in Medicine and Biology Society ◽

10.1109/iembs.2006.259887 ◽

2006 ◽

Cited By ~ 4

Author(s):

S. Sharifi ◽

H. Mirzadeh ◽

M. Imani ◽

M. Atai ◽

R. Bakhshi ◽

...

Keyword(s):

Tissue Engineering ◽

Ethylene Glycol ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Synthesis And Characterization ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Role of Interfacial Interactions on Mechanical Properties of Biomimetic Composites for Bone Tissue Engineering

MRS Proceedings ◽

10.1557/proc-0898-l08-03 ◽

2005 ◽

Vol 898 ◽

Cited By ~ 1

Author(s):

Devendra Verma ◽

Rahul Bhowmik ◽

Bedabibhas Mohanty ◽

Dinesh R Katti ◽

Kalpana S Katti

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Mechanical Response ◽

Density Ratio ◽

Interfacial Interactions ◽

Porous Composites ◽

Properties Of Composites

AbstractInterfaces play an important role in controlling the mechanical properties of composites. Optimum mechanical strength of scaffolds is of prime importance for bone tissue engineering. In the present work, molecular dynamics simulations and experimental studies have been conducted to study effect of interfacial interactions on mechanical properties of composites for bone replacement. In order to mimic biological processes, hydroxyapatite (HAP) is mineralized in presence of polyacrylic acid (PAAc) (in situ HAP). Further, solid and porous composites of in situ HAP with polycaprolactone (PCL) are made. Mechanical tests of composites of in situ HAP with PAAc have shown improved strain recovery, higher modulus/density ratio and also improved mechanical response in simulated body fluid (SBF). Simulation studies indicate potential for calcium bridging between –COO− of PAAc and surface calcium of HAP. This fact is also supported by infrared spectroscopic studies. PAAc modified surfaces of in situ HAP offer means to control the microstructure and mechanical response of porous composites. Nanoindentation experiments indicate that apatite grown on in situ HAP/PCL composites from SBF has improved elastic modulus and hardness. This work gives insight into the interfacial mechanisms responsible for mechanical response as well as bioactivity in biomaterials.

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