Synthesis and Biomedical Applications of Functional Poly(α-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides

2015 ◽  
Vol 48 (7) ◽  
pp. 1777-1787 ◽  
Author(s):  
Qian Yin ◽  
Lichen Yin ◽  
Hua Wang ◽  
Jianjun Cheng
Keyword(s):  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Polymerization ◽  
Hydroxy Acids

scholarly journals Controlled Ring-Opening Polymerization of O-Carboxyanhydrides to Synthesize Functionalized Poly(α-Hydroxy Acids)

2021 ◽  
Vol 03 (01) ◽  
pp. 041-050
Author(s):  
Xiaoqian Wang ◽  
Ai Lin Chin ◽  
Rong Tong
Keyword(s):  
Biomedical Engineering ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Metal Catalyst ◽  
Hydroxy Acids ◽  
Controlled Polymerization ◽  
Biodegradable Polyesters ◽  
Recent Advances

Poly(α-hydroxy acids), as a family of biodegradable polyesters, are valuable materials due to their broad applications in packaging, agriculture, and biomedical engineering. Herein we highlight and explore recent advances of catalysts in controlled ring-opening polymerization of O-carboxyanhydrides towards functionalized poly(α-hydroxy acids), especially metal catalyst-mediated controlled polymerization. Limitations of current polymerization strategies of O-carboxyanhydrides are discussed.

Biodegradable Polymers Derived from Amino Acids for Biological Applications

2010 ◽  
Vol 76 ◽  
pp. 30-35 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Ilanit Hagag ◽  
Michal Kolitz ◽  
Abraham J. Domb ◽  
Jeoshua Katzhendler
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Microwave Assisted Synthesis ◽  
Hydroxy Acids ◽  
Natural Amino Acids ◽  
Direct Condensation ◽  
Positively Charged

Optically active α-hydroxy acids derived from amino acids have been synthesized and polymerized into new biodegradable polyesters. The variety of functional side chains enables the design of positively charged, negatively charged, hydrophobic and hydrophilic chiral building blocks or any combination of these constituents. Hydroxy acids of 15 natural amino acids were prepared with retention of configuration using a straightforward and reliable method of diazotization of α-amino acids. Polyesters were synthesized from these hydroxy acids by a number of methods: direct condensation in bulk, microwave assisted synthesis and ring opening polymerization. The molecular weight of the prepared polymers ranges between 2000 to 5000Da for the direct condensation and the microwave methods, whereas the ring opening polymerization results in high molecular weight polymers (20000 to 30000Da). The polymers were analyzed for their optical activity (Circular Dichroism Spectroscopy), thermal properties (DSC), solubility, molecular weight and polydispersity (GPC), and aqueous degradation. These polymers were tested for their compatibility to neuronal cells growth and differentiation.

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

2020 ◽  
Vol 49 (14) ◽  
pp. 4737-4834 ◽  
Author(s):  
Alicia Rasines Mazo ◽  
Stephanie Allison-Logan ◽  
Fatemeh Karimi ◽  
Nicholas Jun-An Chan ◽  
Wenlian Qiu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Architectural Design ◽  
Ring Opening Polymerization ◽  
Comprehensive Overview

This review provides a comprehensive overview of the latest advances in the synthesis, architectural design and biomedical applications of polypeptides and their hybrids.

Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

2020 ◽  
Vol 04 ◽  
Author(s):  
Manu Singhai ◽  
Sankha Bhattacharya
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Protein Delivery ◽  
Ring Opening ◽  
Biomedical Applications ◽  
High Vacuum ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Biologically Relevant ◽  
Poly Ethylene

Abstract:: Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

scholarly journals Synthesis of Water-Soluble Poly(α-hydroxy acids) from Living Ring-Opening Polymerization of O-Benzyl-l-serine Carboxyanhydrides

2012 ◽  
Vol 1 (4) ◽  
pp. 441-444 ◽  
Author(s):  
Yanbing Lu ◽  
Lichen Yin ◽  
Yanfeng Zhang ◽  
Zhonghai Zhang ◽  
Yunxiang Xu ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Water Soluble ◽  
Hydroxy Acids ◽  
Soluble Poly

scholarly journals Biodegradable vinyl polymers synthesized by nitroxide-mediated radical ring-opening polymerization, for biomedical applications

2016 ◽  
Vol 4 ◽  
Author(s):  
Delplace Vianney ◽  
Gu�gain Elise ◽  
Harrisson Simon ◽  
Tardy Antoine ◽  
Gigmes Didier ◽  
...  
Keyword(s):  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Polymerization ◽  
Radical Ring ◽  
Vinyl Polymers

Smart polymersomes and hydrogels from polypeptide-based polymer systems through α-amino acid N-carboxyanhydride ring-opening polymerization. From chemistry to biomedical applications

2018 ◽  
Vol 83 ◽  
pp. 28-78 ◽  
Author(s):  
Evelina Liarou ◽  
Spyridon Varlas ◽  
Dimitrios Skoulas ◽  
Chrisida Tsimblouli ◽  
Evangelia Sereti ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Polymerization ◽  
Polymer Systems

scholarly journals Metabolic Engineered Biocatalyst: A Solution for PLA Based Problems

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Sundus Riaz ◽  
Nosheen Fatima ◽  
Ahmed Rasheed ◽  
Mehvish Riaz ◽  
Faiza Anwar ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Metabolic Engineering ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Polymerization ◽  
Packaging Material ◽  
Medical Implants ◽  
Direct Production ◽  
Conventional Methods ◽  
Direct Condensation

Polylactic acid (PLA) is a biodegradable thermoplastic polyester. In 2010, PLA became the second highest consumed bioplastic in the world due to its wide application. Conventionally, PLA is produced by direct condensation of lactic acid monomer and ring opening polymerization of lactide, resulting in lower molecular weight and lesser strength of polymer. Furthermore, conventional methods of PLA production require a catalyst which makes it inappropriate for biomedical applications. Newer method utilizes metabolic engineering of microorganism for direct production of PLA through fermentation which produces good quality and high molecular weight and yield as compared to conventional methods. PLA is used as decomposing packaging material, sheet casting, medical implants in the form of screw, plate, and rod pin, etc. The main focus of the review is to highlight the synthesis of PLA by various polymerization methods that mainly include metabolic engineering fermentation as well as salient biomedical applications of PLA.

Copolymerization of lactones and bioaromatics via concurrent ring-opening polymerization/polycondensation

2017 ◽  
Vol 19 (8) ◽  
pp. 1877-1888 ◽  
Author(s):  
Ha Thi Hoang Nguyen ◽  
Gabriel N. Short ◽  
Pengxu Qi ◽  
Stephen A. Miller
Keyword(s):  
Thermal Properties ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Random Copolymers ◽  
Hydroxy Acids

Concurrent ring-opening polymerization/polycondensation of lactones and bioaromatic hydroxy-acids yields random copolymers with improved and controlled thermal properties.

Block Copolymers based on Poly(butylene adipate) and Poly(L-lactic acid) for Biomedical Applications: Synthesis, Structure and Thermo-Dynamical Studies

Soft Matter ◽  
2021 ◽  
Author(s):  
Vasiliki Karava ◽  
Aggeliki Siamidi ◽  
Marilena Vlachou ◽  
Evi Christodoulou ◽  
Alexandra Zamboulis ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Polymerization ◽  
Melt Polycondensation

This work describes the synthesis of poly(butylene adipate) (PBAd), by melt polycondensation, poly(L-lactic acid) (PLLA), by ring opening polymerization, and the new block copolymers PLLA/PBAd in ratios 90/10, 95/5, 75/25...

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