Segmental flexibility of immunoglobulin G antibody molecules in solution: a new interpretation

Biochemistry ◽  
1981 ◽  
Vol 20 (24) ◽  
pp. 6842-6852 ◽  
Author(s):  
Douglas C. Hanson ◽  
Juan Yguerabide ◽  
Verne N. Schumaker
Keyword(s):  
Immunoglobulin G ◽  
New Interpretation ◽  
Segmental Flexibility

Segmental flexibility in pig immunoglobulin G studied by neutron spin-echo technique

Biopolymers ◽  
1985 ◽  
Vol 24 (9) ◽  
pp. 1769-1784 ◽  
Author(s):  
Yolande Alpert ◽  
László Cser ◽  
Béla Faragó ◽  
František Franěk ◽  
Ferenc Mezei ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Spin Echo ◽  
Neutron Spin ◽  
Neutron Spin Echo ◽  
Spin Echo Technique ◽  
Segmental Flexibility

Immunoglobulin G antibody bound to the C1q subcomponent of human complement exhibits segmental flexibility

1985 ◽  
Vol 183 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Douglas C. Hanson ◽  
Verne N. Schumaker
Keyword(s):  
Immunoglobulin G ◽  
Human Complement ◽  
Segmental Flexibility

scholarly journals Conversion of incomplete antibodies to direct agglutinins by mild reduction: evidence for segmental flexibility within the Fc fragment of immunoglobulin G.

1977 ◽  
Vol 74 (6) ◽  
pp. 2531-2535 ◽  
Author(s):  
D. G. Romans ◽  
C. A. Tilley ◽  
M. C. Crookston ◽  
R. E. Falk ◽  
K. J. Dorrington
Keyword(s):  
Immunoglobulin G ◽  
Fc Fragment ◽  
Mild Reduction ◽  
Segmental Flexibility

scholarly journals Detection of Anti-Leishmania (Leishmania) chagasi Immunoglobulin G by Flow Cytometry for Cure Assessment following Chemotherapeutic Treatment of American Visceral Leishmaniasis

2007 ◽  
Vol 14 (5) ◽  
pp. 569-576 ◽  
Author(s):  
Elenice Moreira Lemos ◽  
Izabelle Teixeira Gomes ◽  
Sílvio Fernando Guimarães Carvalho ◽  
Roberta Dias Rodrigues Rocha ◽  
Jauber Fornaciari Pissinate ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Visceral Leishmaniasis ◽  
Immunoglobulin G ◽  
Leishmania Chagasi ◽  
Performance Indices ◽  
Negative Results ◽  
Serological Reactivity ◽  
New Interpretation ◽  
Low Efficiency ◽  
Chemotherapeutic Treatment

ABSTRACTThe residual serological reactivity observed in patients cured of visceral leishmaniasis (VL) represents the major factor underlying the low efficiency of most anti-Leishmaniaserological approaches to assess posttherapeutic cure in VL. Herein, we have described a detuned flow cytometry-based methodology to detect anti-live (FC-ALPA-immunoglobulin G [IgG]) and anti-fixed (FC-AFPA-IgG)L. chagasipromastigote IgG, along the titration curve (1:2,000 to 1:128,000), as a tool to assess late (12 months after treatment [12 mAT]) and early (2 and 6 mAT) posttherapeutic cure of pediatric American visceral leishmaniasis. Reactivities were reported as the percentage of positive fluorescent parasite (PPFP), using a PPFP of 50% as a cutoff to segregate positive and negative results. Our data demonstrated that both FC-ALPA-IgG at 1:4,000 and FC-ALPA-IgG at 1:32,000 are useful for late cure assessment in VL, with 100% specificity and outstanding likelihood ratio indices. Cure assessment at 6 mAT also showed promising performance indices, identifying 81% and 71.4% of the treated patients with negative results. However, new interpretation parameters were necessary to monitor cure at 2 mAT. We then introduced the differential PPFP (ΔPPFP) of 25% as a new cutoff for early cure assessment at specific serum dilutions to analyze IgG reactivity by FC-ALPA-IgG and FC-AFPA-IgG. Our data demonstrated that at 2 mAT, ΔPPFP was >25% in 60% and 57.1% of treated patients, whereas at 6 mAT, a ΔPPFP of >25% was observed in 100% and 95.2% of samples assayed by FC-ALPA-IgG and FC-AFPA-IgG, respectively. Together, our findings showed the potential of both FC-ALPA-IgG and FC-AFPA-IgG regarding their applicability to detect differential serological reactivity and further contribution to posttherapeutic cure assessment in VL.

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Ultrastructural evidence of transplacental transport of immunoglobulin G in bitches

Reproduction ◽  
2000 ◽  
pp. 315-326 ◽  
Author(s):  
MH Stoffel ◽  
AE Friess ◽  
SH Hartmann
Keyword(s):  
Mammary Gland ◽  
Basement Membrane ◽  
Immunoglobulin G ◽  
Passive Immunity ◽  
Morphological Evidence ◽  
Membrane Material ◽  
Ultrastructural Evidence ◽  
Cytotrophoblast Cells ◽  
Fetal Vessels

In dogs, passive immunity is conferred to fetuses and neonates by the transfer of maternal immunoglobulin G through the placenta during the last trimester of pregnancy and via the mammary gland after parturition, respectively. However, morphological evidence of transplacental transport is still lacking. The aim of the present study was to localize maternal immunoglobulin G in the labyrinthine zone and in the haemophagous zone of the canine placenta by means of immunohistochemistry and immunocytochemistry. In the labyrinthine zone, immunoglobulin G was detected in all the layers of the materno-fetal barrier including the fetal capillaries. Immunoreactivity was particularly prominent in maternal basement membrane material as well as in the syncytiotrophoblast. However, this evidence of transplacental transport of immunoglobulin G originated from a limited number of unevenly distributed maternal vessels only. In the cytotrophoblast of the haemophagous zone, immunoglobulin G was localized to phagolysosomes at various stages but was never detected within fetal vessels. The results indicate that maternal immunoglobulin G is degraded in cytotrophoblast cells of the hemophagous zone and, therefore, that transplacental transport is restricted to a subpopulation of maternal vessels in the labyrinthine zone.

Esotericism and the “Coded Word” in Mormonism

2011 ◽  
Vol 2 (1) ◽  
pp. 29-54
Author(s):  
Clyde Forsberg Jr.
Keyword(s):  
Popular Religion ◽  
Latter Day Saints ◽  
Social Commentary ◽  
Joseph Smith ◽  
Playing Field ◽  
Book Of Mormon ◽  
Divine Inspiration ◽  
History Of ◽  
New Interpretation ◽  
New Religion

In the history of American popular religion, the Latter-day Saints, or Mormons, have undergone a series of paradigmatic shifts in order to join the Christian mainstream, abandoning such controversial core doctrines and institutions as polygamy and the political kingdom of God. Mormon historians have played an important role in this metamorphosis, employing a version (if not perversion) of the Church-Sect Dichotomy to change the past in order to control the future, arguing, in effect, that founder Joseph Smith Jr’s erstwhile magical beliefs and practices gave way to a more “mature” and bible-based self-understanding which is then said to best describe the religion that he founded in 1830. However, an “esoteric approach” as Faivre and Hanegraaff understand the term has much to offer the study of Mormonism as an old, new religion and the basis for a more even methodological playing field and new interpretation of Mormonism as equally magical (Masonic) and biblical (Evangelical) despite appearances. This article will focus on early Mormonism’s fascination with and employment of ciphers, or “the coded word,” essential to such foundation texts as the Book of Mormon and “Book of Abraham,” as well as the somewhat contradictory, albeit colonial understanding of African character and destiny in these two hermetic works of divine inspiration and social commentary in the Latter-day Saint canonical tradition.

BKR (BADAN KEAMANAN RAKYAT): Cikal Bakal Tentara Indonesia?

Metahumaniora ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 389
Author(s):  
Widyo Nugrahanto
Keyword(s):  
Armed Forces ◽  
Civil Defense ◽  
The Other ◽  
Main Subject ◽  
Japanese Occupation ◽  
Historical Method ◽  
New Interpretation

AbstrakPenelitian ini berjudul BKR (Badan Kemanan Rakyat):Cikal Bakal Tentara Indonesia?!. Penelitian ini merupakan interpretasi baru tentang cikal bakal TNI, yang umumnya banyak merujuk pada PETA (Pembela Tanah Air). Metode penelitian yang digunakan adalah Metode Sejarah.Metode Sejarah memiliki empat tahapan yaitu Heuristik, Kritik, Interpretasi dan Historiografi.Sumber-sumber penelitian ini menggunakan koran-koran sezaman, majalah sezaman, dan buku. BKR dianggap sebagai cikal bakal TNI didasarkan beberapa sebab. Pertama, atas dasar legalitas formal, PETA telah dibubarkan sehingga BKR adalah satuan militer yang pertama kali dibentuk setelah Indonesia merdeka. BKR selanjutnya melahirkan pembentukan TKR (Tentara Keamanan Rakyat), TKR (Tentara Keselamatan Rakyat), TRI (Tentara Republik Indonesia) dan TNI (Tentara Nasional Indonesia). Kedua, jika PETA dianggap sebagai cikal bakal TNI, maka KNIL dan beberapa satuan keprajuritan diabaikan. Padahal, beberapa bekas perwira KNIL memiliki peran penting di tubuh BKR hingga TNI.Kata kunci: BKR, Tentara, TNIAbstractThe main subject this study is BKR – Indonesian civil defense corps – as origin of Indonesian Military. This study is new interpretation about the origin of TNI (Indonesian National Armed Forces) now. Many opinion refer to PETA as civil defense corps in Japanese occupation era. Study emlpoys a Historical Method, which consists of four stage: Heuristic, Critic, Interpretation, Historiography. The study utilize some sources such as newspaper, magazine, and book. Main finding of this study is PETA had dispersed as legality and formally and BKR was formed as the firts corps after Independence of Indonesia. Futhermore, BKR changed to TKR (Tentara Keamanan Rakyat), TKR (Tentara Keselamatan Rakyat), TRI (Tentara Republik Indonesia) until TNI (Tentara Nasional Indonesia). If PETA is considered as origins of Indonesian Military, then it ignore KNIL – a colonial armed forces – and the other defence corps. Even though the eks KNIL’s officer have important role in military managenment of BKR until TNI.Keywords: BKR, Military, TNI

BKR (BADAN KEAMANAN RAKYAT): Cikal Bakal Tentara Indonesia?

Metahumaniora ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 389
Author(s):  
Widyo Nugrahanto
Keyword(s):  
Armed Forces ◽  
Civil Defense ◽  
The Other ◽  
Main Subject ◽  
Japanese Occupation ◽  
Historical Method ◽  
New Interpretation

AbstrakPenelitian ini berjudul BKR (Badan Kemanan Rakyat):Cikal Bakal Tentara Indonesia?!. Penelitian ini merupakan interpretasi baru tentang cikal bakal TNI, yang umumnya banyak merujuk pada PETA (Pembela Tanah Air). Metode penelitian yang digunakan adalah Metode Sejarah.Metode Sejarah memiliki empat tahapan yaitu Heuristik, Kritik, Interpretasi dan Historiografi.Sumber-sumber penelitian ini menggunakan koran-koran sezaman, majalah sezaman, dan buku. BKR dianggap sebagai cikal bakal TNI didasarkan beberapa sebab. Pertama, atas dasar legalitas formal, PETA telah dibubarkan sehingga BKR adalah satuan militer yang pertama kali dibentuk setelah Indonesia merdeka. BKR selanjutnya melahirkan pembentukan TKR (Tentara Keamanan Rakyat), TKR (Tentara Keselamatan Rakyat), TRI (Tentara Republik Indonesia) dan TNI (Tentara Nasional Indonesia). Kedua, jika PETA dianggap sebagai cikal bakal TNI, maka KNIL dan beberapa satuan keprajuritan diabaikan. Padahal, beberapa bekas perwira KNIL memiliki peran penting di tubuh BKR hingga TNI.Kata kunci: BKR, Tentara, TNIAbstractThe main subject this study is BKR – Indonesian civil defense corps – as origin of Indonesian Military. This study is new interpretation about the origin of TNI (Indonesian National Armed Forces) now. Many opinion refer to PETA as civil defense corps in Japanese occupation era. Study emlpoys a Historical Method, which consists of four stage: Heuristic, Critic, Interpretation, Historiography. The study utilize some sources such as newspaper, magazine, and book. Main finding of this study is PETA had dispersed as legality and formally and BKR was formed as the firts corps after Independence of Indonesia. Futhermore, BKR changed to TKR (Tentara Keamanan Rakyat), TKR (Tentara Keselamatan Rakyat), TRI (Tentara Republik Indonesia) until TNI (Tentara Nasional Indonesia). If PETA is considered as origins of Indonesian Military, then it ignore KNIL – a colonial armed forces – and the other defence corps. Even though the eks KNIL’s officer have important role in military managenment of BKR until TNI.Keywords: BKR, Military, TNI

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