Optimized signal deduction procedure for the MIEZE spectroscopy technique

A method is reported to determine the phase and amplitude of sinusoidally modulated event rates, binned into four bins per oscillation, based on data generated at the resonant neutron spin-echo spectrometer RESEDA at FRM-II. The presented algorithm relies on a reconstruction of the unknown parameters. It omits a calculation-intensive fitting procedure and avoids contrast reduction due to averaging effects. It allows the current data acquisition bottleneck at RESEDA to be relaxed by a factor of four and thus increases the potential time resolution of the detector by the same factor. The approach is explained in detail and compared with the established fitting procedures of time series having four and 16 time bins per oscillation. In addition the empirical estimates of the errors of the three methods are presented and compared with each other. The reconstruction is shown to be unbiased, asymptotic and efficient for estimating the phase. Reconstructing the contrast increases the error bars by roughly 10% as compared with fitting 16 time-binned oscillations. Finally, the paper gives heuristic, analytical equations to estimate the error for phase and contrast as a function of their initial values and counting statistics.

Interaction of a Short Antimicrobial Peptide on Charged Lipid Bilayer: A Case Study on Aurein 1.2 Peptide

Aurein 1.2 is a short but potent α-helical membrane-active antimicrobial peptide that has shown inhibition on a broad spectrum of bacteria and anti-cancer cell activity. With well-defined helicity, amphipathicity, and cationic charges, it readily binds to membranes and causes membrane change and disruption. This study provides details on how Aurein 1.2 interacts with charged lipid membranes by using neutron membrane diffraction (NMD) and neutron spin echo (NSE) spectroscopy on complex peptide-membrane systems. NMD provides higher resolution lipid bilayer structures than solution scattering. NMD revealed the peptide is mostly associated in the lipid headgroup region. Even at moderately high concentrations (e.g., peptide:lipid ratio of 1:30), aurein is located at the acyl chain-headgroup region without deep penetration into the hydrophobic acyl chain. However, it does reduce the elasticity of the membrane at that concentration, which was corroborated by the NSE results. Furthermore, NSE shows that aurein first softens the membrane, like other α-helical peptides at low concentration, but then makes the membrane much more rigid, even without membrane pore formation. The evidence shows that the action of aurein is quite strong for modifying charged lipid distribution without the need to form membrane pores or disintegrate membranes.

Quenching of Isovector and Isoscalar Spin-M1 Excitation Strengths in N = Z Nuclei

Spin-M1 excitations of nuclei are important for describing neutrino reactions in supernovae or in neutrino detectors since they are allowed transitions mediated by neutral current neutrino interactions. The spin-M1 excitation strength distributions in self-conjugate N=Z nuclei were studied by proton inelastic scattering at forward angles for each of isovector and isoscalar excitations as reported in H. Matsubara et al., Phys. Rev. Lett. 115, 102501 (2015). The experiment was carried out at the Research Center for Nuclear Physics, Osaka University, employing a proton beam at 295 MeV and the high-resolution spectrometer Grand Raiden. The measured cross-section of each excited state was converted to the squared nuclear matrix elements of spin-M1 transitions by applying a unit cross-section method. Comparison with predictions by a shell-model has revealed that isoscalar spin-M1 strengths are not quenched from the prediction although isovector spin-M1 strengths are quenched similarly with Gamow-Teller strengths in charged-current reactions. This finding hints at an important origin of the quenching of the strength relevant to neutrino scattering, that is, the proton-neutron spin-spin correlation in the ground state of the target nucleus. In this manuscript we present the details of the unit cross-section method used in the data analysis and discuss the consistency between the quenching of the isoscalar magnetic moments and that of the isoscalar spin-M1 strengths.