The Role of Ultrahigh Resolution Chromatography in the Chemical Industry

1984 ◽  
pp. 199-222
Author(s):  
H. MICHAEL WIDMER ◽  
KARL GROLIMUND
Keyword(s):  
Chemical Industry ◽  
Ultrahigh Resolution

scholarly journals Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry

2021 ◽  
Vol 9 ◽  
Author(s):  
Daniel Demus ◽  
Annemieke Naber ◽  
Viktoria Dotz ◽  
Bas C. Jansen ◽  
Marco R. Bladergroen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Metabolism ◽  
Large Scale ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Sinapinic Acid ◽  
Chemical Oxidation ◽  
Ultrahigh Resolution ◽  
Apolipoprotein Ciii

Apolipoprotein-CIII (apo-CIII) is a glycoprotein involved in lipid metabolism and its levels are associated with cardiovascular disease risk. Apo-CIII sialylation is associated with improved plasma triglyceride levels and its glycosylation may have an effect on the clearance of triglyceride-rich lipoproteins by directing these particles to different metabolic pathways. Large-scale sample cohort studies are required to fully elucidate the role of apo-CIII glycosylation in lipid metabolism and associated cardiovascular disease. In this study, we revisited a high-throughput workflow for the analysis of intact apo-CIII by ultrahigh-resolution MALDI FT-ICR MS. The workflow includes a chemical oxidation step to reduce methionine oxidation heterogeneity and spectrum complexity. Sinapinic acid matrix was used to minimize the loss of sialic acids upon MALDI. MassyTools software was used to standardize and automate MS data processing and quality control. This method was applied on 771 plasma samples from individuals without diabetes allowing for an evaluation of the expression levels of apo-CIII glycoforms against a panel of lipid biomarkers demonstrating the validity of the method. Our study supports the hypothesis that triglyceride clearance may be regulated, or at least strongly influenced by apo-CIII sialylation. Interestingly, the association of apo-CIII glycoforms with triglyceride levels was found to be largely independent of body mass index. Due to its precision and throughput, the new workflow will allow studying the role of apo-CIII in the regulation of lipid metabolism in various disease settings.

scholarly journals Reaping the Benefits of Long Term Relationship with Suppliers: An Evidence from the Saudi Chemical Industry

2016 ◽  
Vol 11 (8) ◽  
pp. 203
Author(s):  
Khalid M. Al-Shuaibi
Keyword(s):  
Supply Chain ◽  
Structural Equation Modeling ◽  
Financial Performance ◽  
Chemical Industry ◽  
Indirect Effect ◽  
Structural Equation ◽  
Equation Modeling ◽  
Supply Chain Performance

<p>Long term relationship with suppliers is broadly considered a vital contributor to supply chain performance by both practitioners and researchers. This paper investigates the role of long term relationship in strategic supplier partnership and financial performance (SSP-LR-P model). Specifically, it has observed the role of long-term supplier relationship as the driver of integration. Using structural Equation modeling (SEM) to analyze the data from 401 Saudi chemical and petrochemical firms, it is found that strategic supplier partnership has a significant direct and indirect effect on firms’ performance through the mediation of long term relationship.</p>

The role of the chemical industry in improving the effectiveness of agriculture

1985 ◽  
Vol 310 (1144) ◽  
pp. 201-213 ◽  
Keyword(s):  
Genetic Engineering ◽  
Plant Growth ◽  
Chemical Industry ◽  
Crop Yields ◽  
Crop Improvement ◽  
Application Technology ◽  
Novel Technology ◽  
Basic Plant ◽  
Technological Opportunities

The development and marketing of novel technology by the chemical industry has been a fundamental ingredient in the improvement of crop yields. Further advances will result from the continuing development of more effective pesticides. Improved application technology and better diagnosis of precise crop requirements will also lead to the more efficient usage of existing and future products. New approaches to crop improvement based on chemical plant-growth regulators and genetic engineering of plants represent major technological opportunities for the future. Realization of these opportunities demands a substantially increased investment in basic plant research, a requirement already recognized within the chemical industry.

scholarly journals Productivity, Product Differentiation And Profitability In The Greek Chemical Industry: An Empirical Analysis, 1991 And 2001

2011 ◽  
Vol 4 (10) ◽  
Author(s):  
Eriotis Nikolaos ◽  
Poutos I. Evangelos ◽  
Vasiliou Dimitris ◽  
Ventura Neokismidi Zoe
Keyword(s):  
Production Process ◽  
Cross Section ◽  
Product Differentiation ◽  
Chemical Industry ◽  
Labour Productivity ◽  
Efficient Production ◽  
Data Set ◽  
The Relationship ◽  
Section Analysis

The purpose of this study is to investigate the relationship between the profitability of the firm and its R&D expenditures. We separate R&D expenditures in two main categories, R&D that focuses on the product differentiation and R&D that concerns improvements in production process. The latter leads to more efficient production, which can be measured by labour productivity. We estimate our model using cross section analysis and test the significance of each one of rhe R&D expenditures in firms profitability. Our model was applied to the Greek chemical industry, for a data set of 124 enterprises, in two distinct years, 1991 and 2001. Our findings support that the role of productivity is growing within time.

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