scholarly journals Advances in Polymeric Matrices and Drug Particle Engineering

2006 ◽  
pp. 2-11
Author(s):  
Sönke Svenson
Keyword(s):  
Particle Engineering ◽  
Polymeric Matrices ◽  
Drug Particle

An Overview of Optimization of Spherical Crystallisation Process

2013 ◽  
Vol 6 (4) ◽  
pp. 2203-2209
Author(s):  
N B Bhagat ◽  
A V Yadav ◽  
P R Mastud ◽  
R A Khutale
Keyword(s):  
Physical Phenomenon ◽  
Chemical Properties ◽  
Spherical Shape ◽  
Particle Engineering ◽  
Spherical Crystallization ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Rate Selection ◽  
Pharmaceutical Agents ◽  
Spherical Crystals

In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is important for obtaining the ideal spherical crystal agglomerates. It includes stirring rate, selection of solvent, pH, temperature etc. which affects on the physico-chemical properties of crystals. These optimizing parameters play its specific role in formation of spherical crystals. Stirring rate affects the shape as well as size of the final agglomerates and solvent selection helps in the formation of maximum amount of agglomerates in the system. The factors like pH and temperature should be maintained in case of drugs which show polymorphism. Apart from this, several others physical phenomenon or parameters like interfacial tension and rate of crystallisation are also important for thorough optimization of process.  

Amorphous or Crystalline? A Comparison of Particle Engineering Methods and Selection

2015 ◽  
Vol 21 (40) ◽  
pp. 5789-5801 ◽  
Author(s):  
Sachin Thakkar ◽  
Kristin Fathe ◽  
Hugh Smyth
Keyword(s):  
Particle Engineering

Effect of pH on the dissolution of drug particle dispersed in solid matrix of hydrogenated soya phospholipid

1989 ◽  
Vol 49 (2) ◽  
pp. 179-181 ◽  
Author(s):  
Koichi Takahashi ◽  
Toyoshi Katagi ◽  
Satoko Tamagawa ◽  
Toshiaki Nishihata
Keyword(s):  
Solid Matrix ◽  
Effect Of Ph ◽  
Drug Particle

scholarly journals In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ
Keyword(s):  
Drug Carrier ◽  
Magnesium Stearate ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Powder Inhalation ◽  
Particle Coating ◽  
Lower Drug ◽  
Dry Particle Coating ◽  
Coarse Model ◽  
Carrier Systems

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.

Bioinspired Particle Engineering for Non-invasive Inhaled Drug Delivery to the Lungs

2021 ◽  
pp. 112324
Author(s):  
Snehal K. Shukla ◽  
Apoorva Sarode ◽  
Dipti D. Kanabar ◽  
Aaron Muth ◽  
Nitesh K. Kunda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Engineering ◽  
Non Invasive ◽  
Inhaled Drug Delivery

Controlled release of pentoxifylline from polymeric matrices

1998 ◽  
Vol 32 (8) ◽  
pp. 440-442 ◽  
Author(s):  
O. N. Pozharitskaya ◽  
V. A. Vainshtein
Keyword(s):  
Controlled Release ◽  
Polymeric Matrices

scholarly journals Fenofibrate Nanocrystal Composite Microparticles for Intestine-Specific Oral Drug Delivery System

2019 ◽  
Vol 12 (3) ◽  
pp. 109 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Liang Chen ◽  
Lu Zhang ◽  
Midhun B. Thomas ◽  
Rajesh N. Davé
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Imaging System ◽  
Oral Drug ◽  
Burst Release ◽  
Particle Engineering ◽  
Oral Drug Delivery System ◽  
Innovative Idea ◽  
Fast Dissolution ◽  
A Site

Hydrophobic drug nanocrystals (NCs) manufactured by particle engineering have been extensively investigated for enhanced oral bioavailability and therapeutic effectiveness. However, there are significant drawbacks, including fast dissolution of the nanocrystals in the gastric environment, leading to physicochemical instability. To solves this issue, we developed an innovative technique that involves the encapsulation of nanocrystals in composite spherical microparticles (NCSMs). Fenofibrate (FNB) NCs (FNB-NCs) manufactured by a wet stirred media milling (WSMM) technique and an ionotropic crosslinking method were used for FNB-NC encapsulation within gastroresistant NCSMs. Various solid-state methods were used for characterizing NCSMs. The pH-sensitive NCSMs showed a site-specific release pattern at alkaline pH and nearly 0% release at low pH (gastric environment). This phenomenon was confirmed by a real-time in situ UV-imaging system known as the surface dissolution imager (SDI), which was used to monitor drug release events by measuring the color intensity and concentration gradient formation. All these results proved that our NCSM approach is an innovative idea in oral drug delivery systems, as it resolves significant challenges in the intestine-specific release of hydrophobic drugs while avoiding fast dissolution or burst release.

Luminescence of polymer electrolytes containing europium (III)

1995 ◽  
Vol 10 (1) ◽  
pp. 202-210 ◽  
Author(s):  
L.D. Carlos ◽  
M. Assunção ◽  
L. Alcácer
Keyword(s):  
Polymer Electrolytes ◽  
Morphological Changes ◽  
Emission Spectra ◽  
Emission Lines ◽  
Hypersensitive Transition ◽  
Polymeric Matrices ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Poly Propylene ◽  
Europium Concentration

The excitation and emission spectra of polymeric matrices—poly(ethylene oxide), PEO, and poly(propylene oxide), PPO—containing different concentrations of EuBr3 were recorded and most of the observed transitions identified. The Stark components of the 7F0−4, 5D0 levels and the corresponding barycenters were calculated based on the emission lines assignment to the 5D0,1 → 7F0−4 transitions. The spectra were discussed in terms of a C2v local Eu3+ coordination. The relative intensity of the 5D0 → 7F2 hypersensitive transition was related to the electrolyte morphological changes due to increasing europium concentration.

Sign in / Sign up

Export Citation Format

Share Document