Self-Assembled Chlorin e6 Conjugated Chondroitin Sulfate Nanodrug for Photodynamic Therapy

2011 ◽  
Vol 12 (5) ◽  
pp. 1724-1730 ◽  
Author(s):  
Fangyuan Li ◽  
Kun Na
Keyword(s):  
Photodynamic Therapy ◽  
Chondroitin Sulfate ◽  
Chlorin E6 ◽  
Self Assembled

Photodynamic therapy using self-assembled nanogels comprising chlorin e6-bearing pullulan

2021 ◽  
Author(s):  
Riku Kawasaki ◽  
Reo Ohdake ◽  
Keita Yamana ◽  
Takuro Eto ◽  
Kouta Sugikawa ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Chlorin E6 ◽  
Therapeutic Effects ◽  
Minimal Invasiveness ◽  
Self Assembled

With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most promising candidates for cancer treatment. Here, we developed a facile self-assembled nanogel using photosensitizer-grafted polysaccharides called...

Ultrasound Enhances the Efficacy of Chlorin e6-Mediated Photodynamic Therapy in MDA-MB-231 Cells

2013 ◽  
Vol 39 (9) ◽  
pp. 1713-1724 ◽  
Author(s):  
Haiping Wang ◽  
Xiaobing Wang ◽  
Pan Wang ◽  
Kun Zhang ◽  
Shuang Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chlorin E6

Self-assembled gold nanostar–NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy

2016 ◽  
Vol 4 (25) ◽  
pp. 4455-4461 ◽  
Author(s):  
Liangcan He ◽  
Joseph Dragavon ◽  
Suehyun Cho ◽  
Chenchen Mao ◽  
Adem Yildirim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Grand Challenge ◽  
Gold Nanostar ◽  
Self Assembled

A grand challenge for medicine is to develop tools to selectively image and treat diseased cells.

Folic Acid Functionalized Chlorin e6-Superparamagnetic Iron Oxide Nanocarriers as a Theranostic Agent for MRI-Guided Photodynamic Therapy

2021 ◽  
Vol 17 (2) ◽  
pp. 205-215
Author(s):  
Zhenbo Sun ◽  
Mingfang Luo ◽  
Jia Li ◽  
Ailing Wang ◽  
Xucheng Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Iron Oxide ◽  
Near Infrared ◽  
Biological Fluids ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Theranostic Agent

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

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