Comment on “Estrogenicity Determination in Sewage Treatment Plants and Surface Waters from the Catalonian Area (NE Spain)”

2001 ◽  
Vol 35 (20) ◽  
pp. 4156-4156 ◽  
Author(s):  
Robert J. Fensterheim
2000 ◽  
Vol 34 (24) ◽  
pp. 5076-5083 ◽  
Author(s):  
Montserrat Solé ◽  
Maria J. López de Alda ◽  
Montserrat Castillo ◽  
Cinta Porte ◽  
Knud Ladegaard-Pedersen ◽  
...  

2007 ◽  
Vol 56 (12) ◽  
pp. 133-140 ◽  
Author(s):  
N. Nakada ◽  
K. Komori ◽  
Y. Suzuki ◽  
C. Konishi ◽  
I. Houwa ◽  
...  

The occurrence of 70 pharmaceutical and personal care products (PPCPs) was investigated in the Tone River. The river has the largest basin in Japan, and the water is utilized not only for farming, but also as a source of water supply. One day in both January and October 2006, surface waters in the river and its tributaries and effluents from sewage treatment plants (STPs) directly discharging into the Tone River were collected, the location of which ranged over 150 km along the river. The 70 PPCPs in the samples were concentrated by solid phase cartridge and were measured by LC-MS/MS using three analytical methods. Fifty-seven PPCPs were detected in one or more samples. Bezafibrate, caffeine, carbamazepine, clarithromycin, crotamiton and sulpiride were frequently detected. Mass flow profiles of some PPCPs (e.g., crotamiton) were comparable to cumulative inhabitants in the basin, suggesting that these PPCPs could be markers of population. Total load of each PPCP into the basin from upstream, the tributaries, and the STPs were calculated. The contribution of selected PPCPs from the tributaries with lower sewerage system coverage was dominant compared to those from upstream and the STPs, suggesting the installation of sewerage systems is necessary to reduce the load of PPCPs in the Tone River basin.


2008 ◽  
Vol 5 (3) ◽  
pp. 194 ◽  
Author(s):  
Andrea Schuetze ◽  
Thomas Heberer ◽  
Susanne Juergensen

Environmental context. Crystal violet (CV), also known as gentian violet, is a triphenylmethane dye used as a veterinary drug for the treatment of ornamental fish infected with the parasitic protozoa Ichthyophthirius multifiliis. CV is a suspected carcinogen not registered for use with food-producing animals in the European Union, Australia, the US and some other countries. The results from this study now demonstrate that residues of leuco CV, the main metabolite of CV, may occur as an organic contaminant in samples of wild eels caused by discharges of municipal sewage effluents. Abstract. Crystal violet (CV) and leucocrystal violet (LCV) were found in the tissues of wild eels caught from surface waters under the influence of effluents discharged by municipal sewage treatment plants (STPs). LCV was the dominant residue detected with total concentrations up to 6.7 μg kg–1 fresh weight in tissues of eels caught from lakes, rivers and a canal in Berlin, Germany. The occurrence of the residues found in 35 out of 45 samples could directly be linked to the presence of discharges by municipal STPs into the receiving surface waters. CV is a multiple-use compound that is also used as a biological stain and to colour materials such as textiles, paints and printing inks. Thus, it seems very likely that the residues of CV found in the eel samples originate from such uses and from legal uses of CV as a veterinary drug for the treatment of ornamental fish. The results obtained from this study are the first report of background contamination by CV found in samples of fish not intentionally treated with this agent. Although the residues of CV and LCV measured in the tissues of the eels were very low, an oral exposure to residues of CV or LCV should be avoided with regard to their mutagenic and carcinogenic potential. According to European Union law, zero tolerance applies to all residues of CV and LCV found in food for human consumption, as CV is not registered for use as a veterinary drug.


2003 ◽  
Vol 22 (12) ◽  
pp. 2881 ◽  
Author(s):  
Chris D. Metcalfe ◽  
Xiu-Sheng Miao ◽  
Brenda G. Koenig ◽  
John Struger

2012 ◽  
Vol 110 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Jess G. Kohlert ◽  
Brian P. Mangan ◽  
Christine Kodra ◽  
Linsay Drako ◽  
Emily Long ◽  
...  

The failure of sewage treatment plants to remove pharmaceuticals such as fluoxetine from waste water has become a concern given that these products are being detected in the surface waters of many countries of the world. The effects of fluoxetine in sub-lethal doses on the neural systems and behaviors of aquatic life are worthy of investigation. This study investigated the effects of sub-lethal amounts fluoxetine dissolved in water on the aggressive and locomotor behaviors of 44 male Betta splendens. Fish treated with 705 μg/1 of fluoxetine and 350 μg/1 of fluoxetine generally demonstrated significant decreases in locomotion and number of aggressive attacks compared to 0 μg/1 of fluoxetine (controls) on Days 11 and 19 of drug exposure and persisted for at least 13 days after removal of fluoxetine. Consistent with decreases in the number of aggressive attacks, there was a significant increase in aggression-response time to a perceived intruder for treated males on Days 11 and 19 and persisted for 6 days following removal of fluoxetine. However, the differences in aggressive and locomotor behaviors seen in the fluoxetine-treated groups were indistinguishable from controls three weeks following drug removal.


2015 ◽  
Vol 81 ◽  
pp. 356-365 ◽  
Author(s):  
Lieke J.C. Coppens ◽  
Jos A.G. van Gils ◽  
Thomas L. ter Laak ◽  
Bernard W. Raterman ◽  
Annemarie P. van Wezel

Proceedings ◽  
2018 ◽  
Vol 2 (20) ◽  
pp. 1288
Author(s):  
Anita Leovac Maćerak ◽  
Đurđa Kerkez ◽  
Milena Bečelić-Tomin ◽  
Dragana Tomašević Pilipović ◽  
Aleksandra Kulić ◽  
...  

Diclofenac (DCF) and metformin (MET) are pharmaceuticals often detected in influents and effluents of municipal sewage treatment plants and surface waters which may cause adverse effects to human health and the environment. In recent years, advanced oxidation processes (AOPs) have been demonstrated to be effective technology for the removal of many organic pollutants. The objective of this study was to evaluate the removal and toxicity of investigated pharmaceuticals by UV and UV/H2O2 processes. UV irradiation was provided by a Pen Ray lamp emission at 254 nm which was covered with a quartz tube and placed in the middle of the reactor. Experimental conditions of the process were: [DIC, MET] = 10 mg/L, [H2O2] = 2.5 mM, reaction time 3 h. Results obtained by only UV exposition of solution showed that diclofenac and metformin were degradated 30% and 50% during 3 h test. Addition of 2.5 mM H2O2 to photo reactor contributed to 90% and 100% removal of DCF and MET, respectively. Inhibition toxicity test of MET increased in the following range: 13% (C0) < 38% (UV) < 77% (UV/ H2O2), while toxicity measured for DCF solutions followed the range: 33% (UV) < 75% (C0) < 78% (UV/H2O2). The results confirmed that addition of hydrogen-peroxide accelerated the removal of investigated pharmaceuticals, but at the same time, lead to formation of the more toxic intermediates. The possible reason for better removal efficiency of metformin can be related to its simpler aliphatic structure in comparison to more aromatic diclofenac.


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