XANES Determination of the Platinum Oxidation State Distribution in Cancer Cells Treated with Platinum(IV) Anticancer Agents

2003 ◽  
Vol 125 (25) ◽  
pp. 7524-7525 ◽  
Author(s):  
Matthew D. Hall ◽  
Garry J. Foran ◽  
Mei Zhang ◽  
Philip J. Beale ◽  
Trevor W. Hambley
Keyword(s):  
Cancer Cells ◽  
Oxidation State ◽  
Anticancer Agents ◽  
State Distribution ◽  
Oxidation State Distribution

Solvent control of oxidation state distribution and electronic delocalization in an osmium-ruthenium, mixed-metal dimer

1986 ◽  
Vol 108 (17) ◽  
pp. 5349-5350 ◽  
Author(s):  
Joseph T. Hupp ◽  
Gregory A. Neyhart ◽  
Thomas J. Meyer
Keyword(s):  
Oxidation State ◽  
State Distribution ◽  
Mixed Metal ◽  
Electronic Delocalization ◽  
Solvent Control ◽  
Oxidation State Distribution

Plutonium oxidation state distribution in natural clay and goethite

2009 ◽  
Vol 282 (3) ◽  
pp. 793-797 ◽  
Author(s):  
G. Lujanienė ◽  
J. Šapolaitė ◽  
E. Radžiūtė ◽  
V. Aninkevičius
Keyword(s):  
Oxidation State ◽  
Natural Clay ◽  
State Distribution ◽  
Oxidation State Distribution

Effect of metal exchange (Os vs. Ru) and co-ligand variation (Cl−vs. acac−) on the oxidation state distribution in complexes of an o-phenylenediamido(2−)/o-quinonediimine redox system

2009 ◽  
pp. 7778 ◽  
Author(s):  
Sudipta Chatterjee ◽  
Priti Singh ◽  
Jan Fiedler ◽  
Radka Baková ◽  
Stanislav Záliš ◽  
...  
Keyword(s):  
Oxidation State ◽  
Redox System ◽  
Metal Exchange ◽  
State Distribution ◽  
Oxidation State Distribution

scholarly journals Influence of ethylenediaminetetraacetic acid on the long-term oxidation state distribution of plutonium

Chemosphere ◽  
2021 ◽  
Vol 274 ◽  
pp. 129741
Author(s):  
Nicole A. DiBlasi ◽  
Ezgi Yalçintas ◽  
Floyd E. Stanley ◽  
Donald T. Reed ◽  
Amy E. Hixon
Keyword(s):  
Oxidation State ◽  
Ethylenediaminetetraacetic Acid ◽  
State Distribution ◽  
Oxidation State Distribution

scholarly journals Oxidation-state distribution of plutonium in surface and subsurface waters at Thule, northwest Greenland

2000 ◽  
Vol 52 (3) ◽  
pp. 697-703 ◽  
Author(s):  
C.A McMahon ◽  
L León Vintró ◽  
P.I Mitchell ◽  
H Dahlgaard
Keyword(s):  
Oxidation State ◽  
State Distribution ◽  
Subsurface Waters ◽  
Oxidation State Distribution ◽  
Surface And Subsurface Waters

Development of Experimental and Theoretical Methodology for Determination of Characteristics of central Metabolism Regulation in Cancer Cells

2012 ◽  
Vol 120 (10) ◽  
Author(s):  
D Shaumarova ◽  
A Benito ◽  
J Centelles ◽  
S Marin Martinez ◽  
V Selivanov ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Central Metabolism ◽  
Metabolism Regulation

Glycolysis Inhibition as a Strategy for Hepatocellular Carcinoma Treatment?

2018 ◽  
Vol 19 (1) ◽  
pp. 26-40 ◽  
Author(s):  
A.P. Alves ◽  
A.C. Mamede ◽  
M.G. Alves ◽  
P.F. Oliveira ◽  
S.M. Rocha ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Glucose Transporter ◽  
Public Health Problem ◽  
High Morbidity ◽  
Curative Intent ◽  
Malignant Liver Tumor ◽  
Glucose Transporter 1 ◽  
Inhibition Of Glycolysis

Hepatocellular carcinoma (HCC) is the most frequently detected primary malignant liver tumor, representing a worldwide public health problem due to its high morbidity and mortality rates. The HCC is commonly detected in advanced stage, precluding the use of treatments with curative intent. For this reason, it is crucial to find effective therapies for HCC. Cancer cells have a high dependence of glycolysis for ATP production, especially under hypoxic environment. Such dependence provides a reliable possible strategy to specifically target cancer cells based on the inhibition of glycolysis. HCC, such as other cancer types, presents a clinically well-known upregulation of several glycolytic key enzymes and proteins, including glucose transporters particularly glucose transporter 1 (GLUT1). Such enzymes and proteins constitute potential targets for therapy. Indeed, for some of these targets, several inhibitors were already reported, such as 2-Deoxyglucose, Imatinib or Flavonoids. Although the inhibition of glycolysis presents a great potential for an anticancer therapy, the development of glycolytic inhibitors as a new class of anticancer agents needs to be more explored. Herein, we propose to summarize, discuss and present an overview on the different approaches to inhibit the glycolytic metabolism in cancer cells, which may be very effective in the treatment of HCC.

Pyrrolizines as Potential Anticancer Agents: Design, Synthesis, Caspase-3 activation and Micronucleus (MN) Induction

2019 ◽  
Vol 18 (15) ◽  
pp. 2124-2130
Author(s):  
Amany Belal
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Caspase 3 ◽  
Assay Method ◽  
Breast Adenocarcinoma ◽  
Compound I ◽  
Design Synthesis ◽  
Ic50 Values ◽  
New Compounds

Background: For further exploration of the promising pyrrolizine scaffold and in continuation of our previous work, that proved the potential anticancer activity of the hit compound I, a new series of pyrrolizines 2-5 and 7-9 were designed and synthesized. Methods: Structures of the new compounds were confirmed by IR, 1H-NMR, 13C-NMR and elemental analysis. Antitumor activity for the prepared compounds against human breast adenocarcinoma (MCF-7), liver (HEPG2) and colon (HCT116) cancer cell lines was evaluated using SRB assay method. Result: Compounds 2, 3 and 5 were the most potent on colon cancer cells, their IC50 values were less than 5 µM. Compounds 2, 3 and 8 were the most potent on liver cancer cells, their IC50 values were less than 10 µM. As for MCF7, compounds 2, 7, 8 and 9 were the most active with IC50 values less than 10 µM. We can conclude that combining pyrrolizine scaffold with urea gave abroad spectrum anticancer agent 2 against the three tested cell lines. Micronucleus assays showed that compounds 2, 3, 8 are mutagenic and can induce apoptosis. In addition, caspase-3 activation was evaluated and compound 2 showed increase in the level of caspase-3 (9 folds) followed by 3 (8.28 folds) then 8 (7.89 folds). Conclusion: The obtained results encourage considering these three compounds as novel anticancer prototypes.

Recent Advances in Curcumin Nanocarriers for the Treatment of Different Types of Cancer with Special Emphasis on In Vitro Cytotoxicity and Cellular Uptake Studies

2020 ◽  
Vol 10 (5) ◽  
pp. 577-590
Author(s):  
Jai B. Sharma ◽  
Shailendra Bhatt ◽  
Asmita Sharma ◽  
Manish Kumar
Keyword(s):  
Cancer Cells ◽  
Cellular Uptake ◽  
Anticancer Agents ◽  
Targeted Delivery ◽  
In Vitro Cytotoxicity ◽  
Curcumin Nanoparticles ◽  
Cytotoxicity Studies ◽  
Delivery Technique ◽  
Different Types

Background: The potential use of nanocarriers is being explored rapidly for the targeted delivery of anticancer agents. Curcumin is a natural polyphenolic compound obtained from rhizomes of turmeric, belongs to family Zingiberaceae. It possesses chemopreventive and chemotherapeutic activity with low toxicity in almost all types of cancer. The low solubility and bioavailability of curcumin make it unable to use for the clinical purpose. The necessity of an effective strategy to overcome the limitations of curcumin is responsible for the development of its nanocarriers. Objective: This study is aimed to review the role of curcumin nanocarriers for the treatment of cancer with special emphasis on cellular uptake and in vitro cytotoxicity studies. In addition to this, the effect of various ligand conjugated curcumin nanoparticles on different types of cancer was also studied. Methods: A systematic review was conducted by extensively surfing the PubMed, science direct and other portals to get the latest update on recent development in nanocarriers of curcumin. Results: The current data from recent studies showed that nanocarriers of curcumin resulted in the targeted delivery, higher efficacy, enhanced bioavailability and lower toxicity. The curcumin nanoparticles showed significant inhibitory effects on cancer cells as compared to free curcumin. Conclusion: It can be concluded that bioavailability of curcumin and its cytotoxic effect to cancer cells can be enhanced by the development of curcumin based nanocarriers and it was found to be a potential drug delivery technique for the treatment of cancer.

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