Potentiation of the Cytotoxicity of the Anticancer Agent Tirapazamine by BenzotriazineN-oxides:  The Role of Redox Equilibria

2006 ◽  
Vol 128 (1) ◽  
pp. 245-249 ◽  
Author(s):  
Robert F. Anderson ◽  
Sujata S. Shinde ◽  
Michael P. Hay ◽  
William A. Denny
Keyword(s):  
Anticancer Agent ◽  
Redox Equilibria

Vitamin D as potential therapeutic anticancer agent

2018 ◽  
pp. 1-3
Keyword(s):  
Vitamin D ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Antitumor Agents ◽  
Metastatic Potential ◽  
Anticancer Properties ◽  
Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

scholarly journals Natural Function and Structural Modification of Climacostol, a Ciliate Secondary Metabolite

2020 ◽  
Vol 8 (6) ◽  
pp. 809
Author(s):  
Federico Buonanno ◽  
Elisabetta Catalani ◽  
Davide Cervia ◽  
Cristina Cimarelli ◽  
Enrico Marcantoni ◽  
...  
Keyword(s):  
Chemical Defense ◽  
Secondary Metabolite ◽  
Structural Modification ◽  
Anticancer Agent ◽  
Physiological Function ◽  
Pharmacological Properties ◽  
Ciliated Protozoan ◽  
Natural Function ◽  
Wide Range

The review highlights the main results of two decades of research on climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol), the resorcinolic lipid produced and used by the ciliated protozoan Climacostomum virens for chemical defense against a wide range of predators, and to assist its carnivorous feeding. After the first studies on the physiological function of climacostol, the compound and some analogues were chemically synthesized, thus allowing us to explore both its effect on different prokaryotic and eukaryotic biological systems, and the role of its relevant structural traits. In particular, the results obtained in the last 10 years indicate climacostol is an effective antimicrobial and anticancer agent, bringing new clues to the attempt to design and synthesize additional novel analogues that can increase or optimize its pharmacological properties.

scholarly journals Redox equilibria of manganese peroxidase from Phanerochaetes chrysosporium: functional role of residues on the proximal side of the haem pocket

2000 ◽  
Vol 349 (1) ◽  
pp. 85 ◽  
Author(s):  
Roberto SANTUCCI ◽  
Cristiana BONGIOVANNI ◽  
Stefano MARINI ◽  
Rebecca DEL CONTE ◽  
Ming TIEN ◽  
...  
Keyword(s):  
Manganese Peroxidase ◽  
Functional Role ◽  
Proximal Side ◽  
Redox Equilibria

Aryltetralin-type lignan of Podophyllum: a comprehensive review

2021 ◽  
Vol 11 ◽  
Author(s):  
Dharmendra Kumar ◽  
Mogana Rajagopal ◽  
Gabriel Akyirem Akowuah ◽  
Yong-Xin Lee ◽  
Chua Wei Chong ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Chemical Synthesis ◽  
Chemical Modification ◽  
Broad Spectrum ◽  
Anticancer Agent ◽  
Review Article ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Podophyllotoxin Derivatives

: Podophyllotoxin is a nonalkaloidtoxin aryltetralin lactone lignan, occurring naturally and extracted from the rhizomes and roots of Podophyllum species. Podophyllotoxin and its derivatives have shown to possess a broad spectrum of pharmacological activities, mainly antineoplastic and antiviral properties. Podophyllotoxin is served as a potential anticancer agent and also the precursor for the chemical synthesis of some clinically important anticancer agents.The chemical modification and pharmacological investigation of podophyllotoxin derivatives have become a concern nowadays. Research interest has been stimulated in the innovation of podophyllotoxin derivatives as the semi-synthetic anticancer agent, especially etoposide and teniposide. Podophyllotoxin and its derivatives are available in several formulations and also found to be effective in combination therapy. This review article aims to provide an overview of the role of podophyllotoxin, its mechanism of action, pharmacological activities, pharmacokinetics, available formulations, and its effects in combination therapy. This article also reviewed the biosynthesis, structure and modifications of podophyllotoxin and its derivatives as an anticancer agent.

Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Peptides ◽  
2004 ◽  
Vol 25 (7) ◽  
pp. 1205-1208 ◽  
Author(s):  
Toshiaki Sendo ◽  
Yoshinori Itoh ◽  
Takeshi Goromaru ◽  
Toshio Hirakawa ◽  
Mawako Ishida ◽  
...  
Keyword(s):  
Substance P ◽  
Anticancer Agent ◽  
Hypersensitivity Reactions

Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1

2009 ◽  
Vol 123 (11) ◽  
pp. 1271-1275 ◽  
Author(s):  
S Suzuki ◽  
K Hanata ◽  
H Nanjo ◽  
K Ishikawa
Keyword(s):  
Maxillary Sinus ◽  
Anticancer Agent ◽  
Adenosquamous Carcinoma ◽  
Treatment Guidelines ◽  
Complete Response ◽  
Rare Tumour ◽  
Neck Metastases ◽  
Aggressive Clinical Course ◽  
Uncommon Neoplasm

AbstractBackground:Adenosquamous carcinoma is a very rare tumour which is characterised pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Generally, adenosquamous carcinoma has an aggressive clinical course and is associated with a poor prognosis. Most cases have been treated by surgery alone or combined with radiotherapy. Chemotherapy is rarely used in treating adenosquamous carcinoma, and it has been difficult to establish treatment guidelines due to the paucity of cases.Case:We report a case of adenosquamous carcinoma which arose in the maxillary sinus of a 77-year-old man. Despite surgical treatment and chemoradiotherapy to the primary site, he developed bilateral neck metastases after the surgery. The patient was treated with S-1, a novel oral fluoropyrimidine anticancer agent, with a complete (albeit finite) response.Conclusion:This report presents the aggressive character of adenosquamous carcinoma and the possible role of S-1 in the treatment of this uncommon neoplasm.

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