scholarly journals Dissection of Hydrogen Bond Interaction Network around an Iron–Sulfur Cluster by Site-Specific Isotope Labeling of Hyperthermophilic Archaeal Rieske-Type Ferredoxin

2012 ◽  
Vol 134 (48) ◽  
pp. 19731-19738 ◽  
Author(s):  
Toshio Iwasaki ◽  
Risako Fukazawa ◽  
Yoshiharu Miyajima-Nakano ◽  
Amgalanbaatar Baldansuren ◽  
Shinichi Matsushita ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Isotope Labeling ◽  
Interaction Network ◽  
Hydrogen Bond Interaction ◽  
Iron Sulfur Cluster ◽  
Site Specific ◽  
Sulfur Cluster ◽  
Iron Sulfur ◽  
Bond Interaction

The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron–sulfur cluster biogenesis and oxidative stress defence

2014 ◽  
Vol 459 (3) ◽  
pp. 467-478 ◽  
Author(s):  
Jan Rybniker ◽  
Florence Pojer ◽  
Jan Marienhagen ◽  
Gaëlle S. Kolly ◽  
Jeffrey M. Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mycobacterium Tuberculosis ◽  
Interaction Network ◽  
Cluster Assembly ◽  
Cysteine Desulfurase ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur ◽  
Altered Surface ◽  
Made In

IscS of Mycobacterium tuberculosis is an essential component of iron–sulfur cluster assembly conferring resistance to oxidative stress. The strongly altered surface structure and the extensive protein-interaction network identified in the present study mirrors adaptations made in response to a heavily depleted mycobacterial ISC operon.

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