Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly

2015 ◽  
Vol 137 (26) ◽  
pp. 8603-8610 ◽  
Author(s):  
Iulia Sacui ◽  
Wei-Che Hsieh ◽  
Arunava Manna ◽  
Bichismita Sahu ◽  
Danith H. Ly
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Peptide Nucleic Acids

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors

The Analyst ◽  
2021 ◽  
Author(s):  
Qingteng Lai ◽  
Wei Chen ◽  
Yanke Zhang ◽  
Zheng-Chun Liu
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Dna Probes ◽  
Highly Sensitive ◽  
Increased Sensitivity ◽  
Acid Sensors

Peptide nucleic acids (PNAs) have attracted tremendous interest in the fabrication of highly sensitive electrochemical nucleic acid biosensor due to their higher stability and increased sensitivity than common DNA probes....

scholarly journals Peptide Nucleic Acids: Applications in Biomedical Sciences

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3317
Author(s):  
Eylon Yavin
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acid ◽  
Peptide Nucleic Acids ◽  
Biomedical Sciences

The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]

Altering behavioral responses and dopamine transporter protein with antisense peptide nucleic acids 1 1Abbreviations: DAT, dopamine transporter; and PNA, peptide nucleic acid.

2001 ◽  
Vol 62 (7) ◽  
pp. 929-932 ◽  
Author(s):  
Beth M Tyler-McMahon ◽  
Jennifer A Stewart ◽  
Joshua Jackson ◽  
M.D Bitner ◽  
Abdul Fauq ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Dopamine Transporter ◽  
Peptide Nucleic Acid ◽  
Peptide Nucleic Acids ◽  
Behavioral Responses ◽  
Transporter Protein ◽  
Antisense Peptide

Templated Self-Assembly of Dynamic Peptide Nucleic Acids

Biochemistry ◽  
2017 ◽  
Vol 57 (1) ◽  
pp. 160-172 ◽  
Author(s):  
John M. Beierle ◽  
Yasuyuki Ura ◽  
M. Reza Ghadiri ◽  
Luke J. Leman
Keyword(s):  
Nucleic Acids ◽  
Self Assembly ◽  
Peptide Nucleic Acids

Hydroxyproline-Based DNA Mimics: A Review on Synthesis and Properties

2006 ◽  
Vol 71 (7) ◽  
pp. 929-955 ◽  
Author(s):  
Vladimir A. Efimov ◽  
Oksana G. Chakhmakhcheva
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Phosphonic Acid ◽  
Peptide Nucleic Acids ◽  
Biological Properties ◽  
High Potential ◽  
Physicochemical And Biological Properties

With the aim to improve physicochemical and biological properties of natural oligonucleotides, many types of DNA analogues and mimics are designed on the basis of hydroxyproline and its derivatives, and their properties are evaluated. Among them, two types of DNA mimics representing hetero-oligomers constructed from alternating monomers of phosphono peptide nucleic acids and monomers on the base of trans-1-acetyl-4-hydroxy-L-proline (HypNA-pPNAs) and oligomers constructed from monomers containing (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-phosphonic acid backbone (pHypNAs) are of particular interest. In a set of in vitro and in vivo assays, it was shown that HypNA-pPNAs and pHypNAs demonstrated a high potential for the use in nucleic acid based diagnostics, isolation of nucleic acids and antisense experiments. A review with 53 references.

Facile synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates on an automated peptide synthesizer

2010 ◽  
Vol 17 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Rajendra Joshi ◽  
Deepti Jha ◽  
Wu Su ◽  
Joern Engelmann
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acid ◽  
Peptide Nucleic Acids ◽  
Facile Synthesis ◽  
Peptide Conjugates

scholarly journals Depsipeptide nucleic acids: prebiotic formation, oligomerization, and self-assembly of a new candidate proto-nucleic acid

2020 ◽  
Author(s):  
David M. Fialho ◽  
Suneesh C. Karunakaran ◽  
Katherine W. Greeson ◽  
Isaac Martínez ◽  
Gary B. Schuster ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Rna World ◽  
Chemical Components ◽  
Early Earth ◽  
New Class ◽  
Self Assembling ◽  
World Hypothesis ◽  
Rna World Hypothesis

AbstractThe mechanism by which genetic polymers spontaneously formed on the early Earth is currently unknown. The RNA World hypothesis implies that RNA oligomers were produced prebiotically, but the demonstration of this process has proven challenging. Alternatively, RNA may be the product of evolution and some, or all, of its chemical components may have been preceded by functionally analogous moieties that were more readily accessible under plausible early-Earth conditions. We report a new class of nucleic acid analog, depsipeptide nucleic acid, which displays several properties that make it an attractive candidate for the first informational polymer to arise on the Earth. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these depsipeptide nucleic acid oligomers are capable of complementary self-assembly, and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers may have been relatively facile.

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