Immunochemical Detection of Tissue from the Central Nervous System via Myelin Proteolipid Protein: Adaptation for Food Inspection and Development of Recombinant Bivalent Fab Mini-Antibodies

2010 ◽  
Vol 58 (11) ◽  
pp. 6587-6593 ◽  
Author(s):  
Ingrid Weigel ◽  
Gesine Schulze ◽  
Monika Pischetsrieder
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Proteolipid Protein ◽  
Myelin Proteolipid Protein ◽  
Food Inspection ◽  
Immunochemical Detection ◽  
The Central Nervous System ◽  
Myelin Proteolipid

Myelin Proteolipid Protein (PLP) as a Marker Antigen of Central Nervous System Contaminations for Routine Food Control

2007 ◽  
Vol 55 (17) ◽  
pp. 7114-7123 ◽  
Author(s):  
Carmen Villmann ◽  
Barbara Sandmeier ◽  
Silke Seeber ◽  
Ewald Hannappel ◽  
Monika Pischetsrieder ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Proteolipid Protein ◽  
Food Control ◽  
Myelin Proteolipid Protein ◽  
Marker Antigen ◽  
Myelin Proteolipid

Detection of central nervous system tissue in meat and meat products with a newly developed immunoassay selective for Myelin proteolipid protein

2007 ◽  
Vol 105 (2) ◽  
pp. 871-878 ◽  
Author(s):  
B SANDMEIER ◽  
R BAUERLEIN ◽  
C VILLMANN ◽  
T DUTHORN ◽  
M GAREIS ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Meat Products ◽  
Proteolipid Protein ◽  
Central Nervous System Tissue ◽  
Myelin Proteolipid Protein ◽  
Myelin Proteolipid

scholarly journals Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species

2006 ◽  
Vol 83 (3) ◽  
pp. 415-431 ◽  
Author(s):  
Edward A. Greenfield ◽  
Jayagopala Reddy ◽  
Andrew Lees ◽  
Charissa A. Dyer ◽  
Omanand Koul ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Monoclonal Antibodies ◽  
Proteolipid Protein ◽  
Vertebrate Species ◽  
Myelin Proteolipid Protein ◽  
Myelin Proteolipid

Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System

2001 ◽  
Vol 81 (2) ◽  
pp. 871-927 ◽  
Author(s):  
Nicole Baumann ◽  
Danielle Pham-Dinh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Proteolipid Protein ◽  
Demyelinating Diseases ◽  
Neural Cells ◽  
The Central Nervous System ◽  
Experimental Demyelination ◽  
Pelizaeus Merzbacher Disease ◽  
Spontaneous Mutants ◽  
Extracellular Environment

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and astrocytes constitute macroglia. This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e., markers, for the identification of the different cells, in intact tissues or cultures. In recent years, specific biochemical, immunological, and molecular markers have been identified. Many components specific to differentiating oligodendrocytes and to myelin are now available to aid their study. Transgenic mice and spontaneous mutants have led to a better understanding of the targets of specific dys- or demyelinating diseases. The best examples are the studies concerning the effects of the mutations affecting the most abundant protein in the central nervous myelin, the proteolipid protein, which lead to dysmyelinating diseases in animals and human (jimpy mutation and Pelizaeus-Merzbacher disease or spastic paraplegia, respectively). Oligodendrocytes, as astrocytes, are able to respond to changes in the cellular and extracellular environment, possibly in relation to a glial network. There is also a remarkable plasticity of the oligodendrocyte lineage, even in the adult with a certain potentiality for myelin repair after experimental demyelination or human diseases.

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system

Glia ◽  
2001 ◽  
Vol 35 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Thomas Uschkureit ◽  
Olaf Spörkel ◽  
Heinrich Büssow ◽  
Wilhelm Stoffel
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mouse Model ◽  
Myelin Sheath ◽  
Proteolipid Protein ◽  
Functional Integrity ◽  
The Central Nervous System

scholarly journals Wobbly syndrome in an Africa pygmy hedgehog (Atelerix albiventris): neuropathological and immunohistochemical studies

2019 ◽  
Vol 49 (1) ◽  
Author(s):  
Letícia Batelli de Oliveira ◽  
Matheus Vilardo Lóes Moreira ◽  
Willian Henrique de Magalhães Santos ◽  
Líslie Caroline Oliveira Stuart ◽  
Maria Dolors Pi Castro ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous Tissue ◽  
Axonal Degeneration ◽  
Clinical Signs ◽  
Proteolipid Protein ◽  
Genetic Origin ◽  
The Central Nervous System ◽  
Gross Lesions ◽  
Immunohistochemical Studies ◽  
Myelin Proteolipid

ABSTRACT: A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil, presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochemistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition, there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination, which resulted in the wobbly syndrome described in this report.

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