scholarly journals Exposure to Di-2-Ethylhexyl Phthalate, Di-N-Butyl Phthalate and Bisphenol A through Infant Formulas

2015 ◽  
Vol 63 (12) ◽  
pp. 3303-3310 ◽  
Author(s):  
Teresa Cirillo ◽  
Giuseppe Latini ◽  
Maria Antonietta Castaldi ◽  
Lucia Dipaola ◽  
Evelina Fasano ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Infant Formulas ◽  
Butyl Phthalate ◽  
Ethylhexyl Phthalate

scholarly journals The Association of Bisphenol A and Phthalates with Risk of Breast Cancer: A Meta-Analysis

2021 ◽  
Vol 18 (5) ◽  
pp. 2375
Author(s):  
Ge Liu ◽  
Wei Cai ◽  
Huan Liu ◽  
Haihong Jiang ◽  
Yongyi Bi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bisphenol A ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Case Control Studies ◽  
Common Cancer ◽  
Endocrine Disrupting ◽  
Butyl Phthalate ◽  
Phthalate Metabolite ◽  
Ethylhexyl Phthalate

Background: Breast cancer is the most common cancer and the second leading cause of cancer-related death amongst American women. Endocrine-disrupting chemicals (EDCs), especially bisphenol A (BPA) and phthalates, have adverse effects on human health. However, the association of BPA and phthalates with breast cancer remains conflicting. This study aims to investigate the association of BPA and phthalates with breast cancer. Methods: Correlative studies were identified by systematically searching three electronic databases, namely, PubMed, Web of Sciences, and Embase, up to November 2020. All data were analyzed using Stata 15.0. Results: A total of nine studies, consisting of 7820 breast cancer cases and controls, were included. The urinary phthalate metabolite mono-benzyl phthalate (MBzP) and mono-2-isobutyl phthalate (MiBP) were negatively associated with breast cancer (OR = 0.73, 95% CI: 0.60–0.90; OR = 0.75, 95% CI: 0.58–0.98, respectively). However, the overall ORs for BPA, mono-ethyl phthalate (MEP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(3-carboxypropyl) phthalate (MCPP), and mono-butyl phthalate (MBP) were 0.85 (95% CI: 0.69–1.05), 0.96 (95% CI: 0.62–1.48), 1.12 (95% CI: 0.88–1.42), 1.13 (95% CI: 0.74–1.73), 1.01 (95% CI: 0.74–1.40), 0.74 (95% CI: 0.48–1.14), and 0.80 (95% CI: 0.55–1.15), respectively, suggesting no significant association. The sensitivity analysis indicated that the results were relatively stable. Conclusion: Phthalate metabolites MBzP and MiBP were passively associated with breast cancer, whereas no associations were found between BPA, MEP, MEHHP, MEHP, MEOHP, MCPP, and MBP and breast cancer. More high-quality case-control studies or persuasive cohort studies are urgently needed to draw the best conclusions.

Study of Endocrine Disruptors in the Sediment of a South Brazilian River

2015 ◽  
Vol 1120-1121 ◽  
pp. 862-866
Author(s):  
Irajá Do Nascimento ◽  
Nathália Christine Vieceli ◽  
Michele Schmitz ◽  
Fernanda Glaeser
Keyword(s):  
Gas Chromatography ◽  
Bisphenol A ◽  
Endocrine Disruptors ◽  
River Sediment ◽  
Flame Ionization Detection ◽  
River Contamination ◽  
Ionization Detection ◽  
Flame Ionization ◽  
Organic Extracts ◽  
Ethylhexyl Phthalate

This study investigated the occurrence of di (2-ethylhexyl) phthalate (DEHP) di-n-butylphthalate (DBP) and bisphenol A (BPA) in river sediment. The samples were collected from three selected points and extracted by sonication, using n-hexane and ethanol. The organic extracts were analyzed by gas chromatography with flame ionization detection (GC/FID). DBP and BPA were not detected. The average concentrations of DEHP range from 0.72 (±0.04) to 27.90 (± 3.05) ng g-1 of sediment. The best solvent for the extractions was n-hexane. However ethanol also shows good extraction yields of DEHP. These results showed an important anthropic contribution for the river contamination by endocrine disruptors.

scholarly journals Consequences of a contaminant mixture of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP), two plastic-derived chemicals, on the diversity of coastal phytoplankton

2019 ◽  
Vol 138 ◽  
pp. 385-396 ◽  
Author(s):  
Charaf M’RABET ◽  
Ons Kéfi-Daly Yahia ◽  
Douglas Couet ◽  
Sonia Khadija Maïté Gueroun ◽  
Olivier Pringault
Keyword(s):  
Bisphenol A ◽  
Coastal Phytoplankton ◽  
Ethylhexyl Phthalate

Bisphenol A and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/β-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action

2017 ◽  
Vol 33 (12) ◽  
pp. 901-910 ◽  
Author(s):  
Ünsal Veli Üstündağ ◽  
İsmail Ünal ◽  
Perihan Seda Ateş ◽  
A Ata Alturfan ◽  
Türkan Yiğitbaşı ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Signaling Pathway ◽  
Nuclear Antigen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Minor Effect ◽  
Zebrafish Embryos ◽  
Chemical Action ◽  
Acridine Orange Staining ◽  
Endocrine Disrupting ◽  
Ethylhexyl Phthalate

Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to produce PC. Both DEHP and BPA are known for their potential endocrine disrupting effects. The Wnt/β-catenin signaling pathway has important roles in cell proliferation, cell specification and cell fate determination during embryonic development. Recent reports suggest a link between the Wnt/β-catenin signaling pathway and apoptosis. The aim of this study was to investigate the relation between Wnt/β-catenin signaling and apoptosis in the case of BPA and DEHP exposure in zebrafish embryos. Accordingly, in vivo cell death was assessed using acridine orange staining, and reverse transcription polymerase chain reaction was used to determine the expressions of wnt3a, gsk3β and ccnd1. Proliferative cell nuclear antigen, β-catenin and Wnt3a expressions were determined immunohistochemically. Vitellogenin levels were determined using Enzyme Linked ImmunoSorbent Assay (ELISA). Increased vitellogenin levels, apoptosis, and wnt3a and gsk3β expressions were observed in BPA-exposed zebrafish embryos. Increased apoptosis in the BPA-exposed embryos may be due to the pro-apoptotic changes induced by Wnt3a, whereas DEHP might be suggested to have a minor effect as Wnt3a expression; vitellogenin levels and apoptosis did not increase significantly following exposure to DEHP.

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