The Effect of Exchanging Various Substituents at the 2-Position of 2-Methoxyestradiol on Cytotoxicity in Human Cancer Cell Cultures and Inhibition of Tubulin Polymerization

2002 ◽  
Vol 45 (21) ◽  
pp. 4748-4754 ◽  
Author(s):  
Mark Cushman ◽  
Arasambattu K. Mohanakrishnan ◽  
Melinda Hollingshead ◽  
Ernest Hamel
Keyword(s):  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell

Effects of Altering the Electronics of 2-Methoxyestradiol on Cell Proliferation, on Cytotoxicity in Human Cancer Cell Cultures, and on Tubulin Polymerization

2004 ◽  
Vol 47 (21) ◽  
pp. 5126-5139 ◽  
Author(s):  
Allison B. Edsall ◽  
Arasambattu K. Mohanakrishnan ◽  
Donglai Yang ◽  
Philip E. Fanwick ◽  
Ernest Hamel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell

scholarly journals Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

2020 ◽  
Vol 11 (11) ◽  
pp. 1295-1302
Author(s):  
Kesari Lakshmi Manasa ◽  
Sowjanya Thatikonda ◽  
Dilep Kumar Sigalapalli ◽  
Sowmya Vuppaladadium ◽  
Ganthala Parimala Devi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Proliferative Potential ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Substituted 1

Herein, we have designed and synthesized a library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives (10aa–ef) and evaluated for their anti-proliferative potential against a panel of human cancer cell lines.

Pyrazole–oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

2014 ◽  
Vol 12 (40) ◽  
pp. 7993-8007 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Sowjanya Polepalli ◽  
Vangala Santosh Reddy ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A library of pyrazole–oxadiazole conjugates were synthesized and investigated for their antiproliferative activity in human cancer cell lines.

Synthesis of 2-substituted 17β-hydroxy/17-methylene estratrienes and their in vitro cytotoxicity in human cancer cell cultures

Steroids ◽  
2011 ◽  
Vol 76 (13) ◽  
pp. 1491-1504 ◽  
Author(s):  
Ganapathy Panchapakesan ◽  
Vasudevan Dhayalan ◽  
Nachiappan Dhatchana Moorthy ◽  
Nidhyanandan Saranya ◽  
Arasambattu K. Mohanakrishnan
Keyword(s):  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
In Vitro Cytotoxicity ◽  
Human Cancer Cell

Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues

1991 ◽  
Vol 46 (7-8) ◽  
pp. 706-708 ◽  
Author(s):  
Christiane Tempête ◽  
Michel Devys ◽  
Michel Barbier
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
Biologically Active ◽  
Human Cancer Cell ◽  
Synthetic Analogues ◽  
Cruciferae Family

Abstract Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologically active of these products is brassilexin (LD50= 8 μg/ml).

scholarly journals Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell Cultures

2007 ◽  
Vol 50 (9) ◽  
pp. 2040-2048 ◽  
Author(s):  
Andrew Morrell ◽  
Michael S. Placzek ◽  
Jamin D. Steffen ◽  
Smitha Antony ◽  
Keli Agama ◽  
...  
Keyword(s):  
Chain Length ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Topoisomerase I ◽  
Human Cancer ◽  
Side Chain ◽  
Human Cancer Cell ◽  
Side Chain Length

Quantitative correlation of neutral red dye uptake with cell number in human cancer cell cultures

1987 ◽  
Vol 11 (5) ◽  
pp. 373-378 ◽  
Author(s):  
A FIENNES ◽  
J WALTON ◽  
D WINTERBOURNE ◽  
D MCGLASHAN ◽  
J HERMONTAYLOR
Keyword(s):  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
Neutral Red ◽  
Cell Number ◽  
Human Cancer Cell ◽  
Dye Uptake ◽  
Quantitative Correlation ◽  
Red Dye

Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers

2015 ◽  
Vol 13 (11) ◽  
pp. 3416-3431 ◽  
Author(s):  
Ahmed Kamal ◽  
Vangala Santhosh Reddy ◽  
Anver Basha Shaik ◽  
G. Bharath Kumar ◽  
M. V. P. S. Vishnuvardhan ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
New Class

A new class of pyrazole conjugates were synthesized and evaluated for their antiproliferative activity in human cancer cell lines: 9a, 9b and 9f significantly inhibited cell growth as well as tubulin polymerization.

Studies of Properdin System in Human Cancer Cell Cultures.

1959 ◽  
Vol 102 (1) ◽  
pp. 63-67 ◽  
Author(s):  
C. M. Southam ◽  
M. Tai ◽  
E. L. Greene
Keyword(s):  
Cancer Cell ◽  
Cell Cultures ◽  
Human Cancer ◽  
Human Cancer Cell

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

2015 ◽  
Vol 13 (40) ◽  
pp. 10162-10178 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Bala Bhaskara Rao ◽  
Irfan Khan ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Antiproliferative Agents ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

A series of pyrazole/isoxazole linked arylcinnamide conjugates were synthesized and investigated for their cytotoxic activity against a panel of four human cancer cell lines. Most of them have shown significant cytotoxicity apart from potential tubulin depolymerization activity.

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