Interferometric Down-Conversion of High-Frequency Molecular Vibrations with Time−Frequency-Resolved Coherent Raman Scattering Using Quasi-CW Noisy Light:  C−H Stretching Modes of Chloroform and Benzene

1997 ◽  
Vol 101 (25) ◽  
pp. 4587-4591 ◽  
Author(s):  
Darin J. Ulness ◽  
Michael J. Stimson ◽  
Jason C. Kirkwood ◽  
A. C. Albrecht
Keyword(s):  
Raman Scattering ◽  
High Frequency ◽  
Molecular Vibrations ◽  
Time Frequency ◽  
Coherent Raman Scattering ◽  
Coherent Raman ◽  
Down Conversion

scholarly journals Time-Frequency Resolved Coherent Raman Scattering From Molecular Liquids and Their Mixtures With Quasi-Cw Noisy Light: I(2) CRS Spectrograms

1999 ◽  
Vol 19 (1-4) ◽  
pp. 11-18 ◽  
Author(s):  
Darin J. Ulness ◽  
Michael J. Stimson ◽  
Jason C. Kirkwood ◽  
A. C. Albrecht
Keyword(s):  
Raman Scattering ◽  
Molecular Liquids ◽  
Vibrational Dynamics ◽  
Frequency Shifts ◽  
Time Frequency ◽  
Material Parameters ◽  
Ccd Array ◽  
Coherent Raman Scattering ◽  
Coherent Raman ◽  
Theory And Experiment

It is demonstrated how time-frequency resolved coherent Raman scattering (CRS) signals generated by broadband, non-transform limited, quasi-cw (noisy) light can be sensitive probes of molecular vibrational dynamics. The coherent Raman scattering signals from molecular liquids and their mixtures with noisy light are dispersed onto a CCD array and probed interferometrically to produce time-frequency domain spectrograms. These spectrograms offer an extensive oversampling of the data resulting in improved precision of measured parameters over previous noisy light methods. This technique has been very useful in measuring small changes in material parameters, such as Raman frequency shifts and linewidth changes, in dilution series with Raman inactive diluents. Very recently theory and experiment have extended to include mixtures with multiple Raman resonances. Several examples of experiments are presented and discussed.

scholarly journals Broadband Coherent Raman Scattering Microscopy

2018 ◽  
Vol 12 (9) ◽  
pp. 1800020 ◽  
Author(s):  
Dario Polli ◽  
Vikas Kumar ◽  
Carlo M. Valensise ◽  
Marco Marangoni ◽  
Giulio Cerullo
Keyword(s):  
Raman Scattering ◽  
Coherent Raman Scattering ◽  
Coherent Raman

scholarly journals Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview

2011 ◽  
Vol 16 (2) ◽  
pp. 021106 ◽  
Author(s):  
Sophie Brustlein ◽  
Patrick Ferrand ◽  
Nico Walther ◽  
Sophie Brasselet ◽  
Cyrille Billaudeau ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Light Source ◽  
Optical Parametric Oscillator ◽  
Parametric Oscillator ◽  
Optical Parametric ◽  
Coherent Raman Scattering ◽  
Coherent Raman

scholarly journals Coherent Raman Scattering Microscopy in Oncology Pharmacokinetic Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Junjie Zeng ◽  
Wenying Zhao ◽  
Shuhua Yue
Keyword(s):  
Raman Scattering ◽  
High Speed ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
High Speed Imaging ◽  
Coherent Raman Scattering ◽  
Anti Cancer ◽  
Coherent Raman

The high attrition rates of anti-cancer drugs during clinical development remains a bottleneck problem in pharmaceutical industry. This is partially due to the lack of quantitative, selective, and rapid readouts of anti-cancer drug activity in situ with high resolution. Although fluorescence microscopy has been commonly used in oncology pharmacological research, fluorescent labels are often too large in size for small drug molecules, and thus may disturb the function or metabolism of these molecules. Such challenge can be overcome by coherent Raman scattering microscopy, which is capable of chemically selective, highly sensitive, high spatial resolution, and high-speed imaging, without the need of any labeling. Coherent Raman scattering microscopy has tremendously improved the understanding of pharmaceutical materials in the solid state, pharmacokinetics of anti-cancer drugs and nanocarriers in vitro and in vivo. This review focuses on the latest applications of coherent Raman scattering microscopy as a new emerging platform to facilitate oncology pharmacokinetic research.

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