Proteomics of Huntington’s Disease-Affected Human Embryonic Stem Cells Reveals an Evolving Pathology Involving Mitochondrial Dysfunction and Metabolic Disturbances

2014 ◽  
Vol 13 (12) ◽  
pp. 5648-5659 ◽  
Author(s):  
Leon R. McQuade ◽  
Anushree Balachandran ◽  
Heather A. Scott ◽  
Simer Khaira ◽  
Mark S. Baker ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Mitochondrial Dysfunction ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Metabolic Disturbances

I21 Functional assessment of grafted human embryonic stem cells-derived progenitors in a rat model of huntington’s disease

2018 ◽  
Author(s):  
Ana Garcia ◽  
Marija Fjodorova ◽  
Mariah J Lelos ◽  
Anselme L Perrier ◽  
Marie Michael ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Functional Assessment ◽  
Rat Model ◽  
Embryonic Stem

scholarly journals Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jaisan Islam ◽  
Kyoung Ha So ◽  
Elina KC ◽  
Hyeong Cheol Moon ◽  
Aryun Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Rat Model ◽  
Sham Group ◽  
Embryonic Stem ◽  
Motor Dysfunction ◽  
Control Group

Abstract Background Human embryonic stem cells (hESCs) transplantation had shown to provide a potential source of cells in neurodegenerative disease studies and lead to behavioral recovery in lentivirus transfected or, toxin-induced Huntington's disease (HD) rodent model. Here, we aimed to observe if transplantation of superparamagnetic iron oxide nanoparticle (SPION)-labeled hESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model. Methods All animals were randomly allocated into three groups at first: HD group, sham group, and control group. After six weeks, the animals of the HD group and sham group were again divided into two subgroups depending on animals receiving either ipsilateral or contralateral hESCs transplantation. We performed cylinder test and stepping test every two weeks after AAV2-Htt171-82Q injection and hESCs transplantation. Stem cell tracking was performed once per two weeks using T2 and T2*-weighted images at 4.7 Tesla MRI. We also performed immunohistochemistry and immunofluorescence staining to detect the presence of hESCs markers, huntingtin protein aggregations, and iron in the striatum. Results After hESCs transplantation, the Htt virus-injected rats exhibited significant behavioral improvement in behavioral tests. SPION labeled hESCs showed migration with hypointense signal in MRI. The cells were positive with βIII-tubulin, GABA, and DARPP32. Conclusion Collectively, our results suggested that hESCs transplantation can be a potential treatment for motor dysfunction of Huntington's disease.

scholarly journals Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells

2012 ◽  
Vol 21 (17) ◽  
pp. 3883-3895 ◽  
Author(s):  
Maxime Feyeux ◽  
Fany Bourgois-Rocha ◽  
Amanda Redfern ◽  
Peter Giles ◽  
Nathalie Lefort ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Naturally Occurring ◽  
Disease Mutations ◽  
Transcriptional Changes ◽  
Derivatives Of

scholarly journals Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells

2013 ◽  
Vol 11 (3) ◽  
pp. 1264-1271 ◽  
Author(s):  
Ida Jonson ◽  
Rune Ougland ◽  
Arne Klungland ◽  
Elisabeth Larsen
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Triplet Expansion

CAG repeat instability in embryonic stem cells and derivative spermatogenic cells of transgenic Huntington’s disease monkey

2021 ◽  
Author(s):  
Sujittra Khampang ◽  
Rangsun Parnpai ◽  
Wiriya Mahikul ◽  
Charles A. Easley ◽  
In Ki Cho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Embryonic Stem ◽  
Cag Repeat ◽  
Spermatogenic Cells ◽  
Repeat Instability

356 Human embryonic stem cells improve diastolic function in rats with acute myocardial infarction

2007 ◽  
Vol 6 (1) ◽  
pp. 82-82
Author(s):  
M LINDBOM ◽  
T RAMUNDDAL ◽  
E BOLLANO ◽  
E OMEROVIC ◽  
M SHARINTANG
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Diastolic Function ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression
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