scholarly journals Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells

2012 ◽  
Vol 21 (17) ◽  
pp. 3883-3895 ◽  
Author(s):  
Maxime Feyeux ◽  
Fany Bourgois-Rocha ◽  
Amanda Redfern ◽  
Peter Giles ◽  
Nathalie Lefort ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Naturally Occurring ◽  
Disease Mutations ◽  
Transcriptional Changes ◽  
Derivatives Of

I21 Functional assessment of grafted human embryonic stem cells-derived progenitors in a rat model of huntington’s disease

2018 ◽  
Author(s):  
Ana Garcia ◽  
Marija Fjodorova ◽  
Mariah J Lelos ◽  
Anselme L Perrier ◽  
Marie Michael ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Functional Assessment ◽  
Rat Model ◽  
Embryonic Stem

Proteomics of Huntington’s Disease-Affected Human Embryonic Stem Cells Reveals an Evolving Pathology Involving Mitochondrial Dysfunction and Metabolic Disturbances

2014 ◽  
Vol 13 (12) ◽  
pp. 5648-5659 ◽  
Author(s):  
Leon R. McQuade ◽  
Anushree Balachandran ◽  
Heather A. Scott ◽  
Simer Khaira ◽  
Mark S. Baker ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Mitochondrial Dysfunction ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Metabolic Disturbances

scholarly journals Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jaisan Islam ◽  
Kyoung Ha So ◽  
Elina KC ◽  
Hyeong Cheol Moon ◽  
Aryun Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Human Embryonic Stem Cells ◽  
Rat Model ◽  
Sham Group ◽  
Embryonic Stem ◽  
Motor Dysfunction ◽  
Control Group

Abstract Background Human embryonic stem cells (hESCs) transplantation had shown to provide a potential source of cells in neurodegenerative disease studies and lead to behavioral recovery in lentivirus transfected or, toxin-induced Huntington's disease (HD) rodent model. Here, we aimed to observe if transplantation of superparamagnetic iron oxide nanoparticle (SPION)-labeled hESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model. Methods All animals were randomly allocated into three groups at first: HD group, sham group, and control group. After six weeks, the animals of the HD group and sham group were again divided into two subgroups depending on animals receiving either ipsilateral or contralateral hESCs transplantation. We performed cylinder test and stepping test every two weeks after AAV2-Htt171-82Q injection and hESCs transplantation. Stem cell tracking was performed once per two weeks using T2 and T2*-weighted images at 4.7 Tesla MRI. We also performed immunohistochemistry and immunofluorescence staining to detect the presence of hESCs markers, huntingtin protein aggregations, and iron in the striatum. Results After hESCs transplantation, the Htt virus-injected rats exhibited significant behavioral improvement in behavioral tests. SPION labeled hESCs showed migration with hypointense signal in MRI. The cells were positive with βIII-tubulin, GABA, and DARPP32. Conclusion Collectively, our results suggested that hESCs transplantation can be a potential treatment for motor dysfunction of Huntington's disease.

Mesenchymal Derivatives of Genetically Unstable Human Embryonic Stem Cells Are Maintained Unstable but Undergo Senescence in Culture As Do Bone Marrow–Derived Mesenchymal Stem Cells

2014 ◽  
Vol 16 (1) ◽  
pp. 1-8
Author(s):  
Angeliki Karagiannidou ◽  
Ioanna Varela ◽  
Krinio Giannikou ◽  
Maria Tzetis ◽  
Antonia Spyropoulos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Derivatives Of

scholarly journals Three-dimensional scaffolding to investigate neuronal derivatives of human embryonic stem cells

2012 ◽  
Vol 14 (5) ◽  
pp. 829-838 ◽  
Author(s):  
Pranav Soman ◽  
Brian T. D. Tobe ◽  
Jin Woo Lee ◽  
Alicia A. M. Winquist ◽  
Ilyas Singec ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Derivatives Of

scholarly journals Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells

2013 ◽  
Vol 11 (3) ◽  
pp. 1264-1271 ◽  
Author(s):  
Ida Jonson ◽  
Rune Ougland ◽  
Arne Klungland ◽  
Elisabeth Larsen
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Triplet Expansion

scholarly journals High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes

Stem Cells ◽  
2013 ◽  
Vol 31 (9) ◽  
pp. 1816-1828 ◽  
Author(s):  
Jérémie Charbord ◽  
Pauline Poydenot ◽  
Caroline Bonnefond ◽  
Maxime Feyeux ◽  
Fabrice Casagrande ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
High Throughput ◽  
Human Embryonic Stem Cells ◽  
Chemical Compound ◽  
High Throughput Screening ◽  
Embryonic Stem ◽  
Neuronal Genes ◽  
Derivatives Of

CAG repeat instability in embryonic stem cells and derivative spermatogenic cells of transgenic Huntington’s disease monkey

2021 ◽  
Author(s):  
Sujittra Khampang ◽  
Rangsun Parnpai ◽  
Wiriya Mahikul ◽  
Charles A. Easley ◽  
In Ki Cho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Embryonic Stem ◽  
Cag Repeat ◽  
Spermatogenic Cells ◽  
Repeat Instability

scholarly journals No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
A. N. Bogomazova ◽  
E. M. Vassina ◽  
T. N. Goryachkovskaya ◽  
V. M. Popik ◽  
A. S. Sokolov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Human Embryonic Stem Cells ◽  
Terahertz Radiation ◽  
Embryonic Stem ◽  
Genome Wide ◽  
Damage Response ◽  
Transcriptional Changes
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