Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy

Hao Chen; Scott Grover; Linning Yu; Gregory Walker; Abdul Mutlib

doi:10.1021/tx9003243

Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy

Chemical Research in Toxicology ◽

10.1021/tx9003243 ◽

2010 ◽

Vol 23 (1) ◽

pp. 159-170 ◽

Cited By ~ 20

Author(s):

Hao Chen ◽

Scott Grover ◽

Linning Yu ◽

Gregory Walker ◽

Abdul Mutlib

Keyword(s):

Mass Spectrometry ◽

Human Liver ◽

High Field ◽

Liver Microsomes ◽

Epidermal Keratinocytes ◽

Resonance Spectroscopy ◽

Liquid Chromatography Mass Spectrometry

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Characterization of covalent protein modification by triclosan in vivo and in vitro via three-dimensional liquid chromatography-mass spectrometry: New insight into its adverse effects

Environment International ◽

10.1016/j.envint.2019.105423 ◽

2020 ◽

Vol 136 ◽

pp. 105423 ◽

Cited By ~ 1

Author(s):

Meixian Liu ◽

Na Li ◽

Yida Zhang ◽

Zhiyuan Zheng ◽

Yue Zhuo ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Adverse Effects ◽

Protein Modification ◽

Three Dimensional ◽

Liquid Chromatography Mass Spectrometry ◽

Insight Into

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In vitro metabolites characterization of ponatinib in human liver microsomes using ultra‐high performance liquid chromatography combined with Q‐Exactive‐Orbitrap tandem mass spectrometry

Biomedical Chromatography ◽

10.1002/bmc.4819 ◽

2020 ◽

Vol 34 (6) ◽

Author(s):

Lei Gao ◽

Qiqi Xu ◽

Qingqing Liu ◽

Xiuzhuang Lang

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Human Liver ◽

High Performance ◽

Liver Microsomes ◽

Tandem Mass ◽

Q Exactive

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Metabolites characterization of timosaponin AIII in vivo and in vitro by using liquid chromatography-mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2015.06.015 ◽

2015 ◽

Vol 997 ◽

pp. 236-243 ◽

Cited By ~ 10

Author(s):

Yu Sun ◽

Liyin Liu ◽

Ying Peng ◽

Bingjie Liu ◽

Dongju Lin ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Timosaponin Aiii

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Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2014.03.030 ◽

2014 ◽

Vol 97 ◽

pp. 65-71 ◽

Cited By ~ 20

Author(s):

Lin Yuan ◽

Peipei Jia ◽

Yupeng Sun ◽

Chengcheng Zhao ◽

Xuran Zhi ◽

...

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Cytochrome P450 Enzymes

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In vitro metabolism of BYZX in human liver microsomes and the structural elucidation of metabolite by liquid chromatography–mass spectrometry method

Journal of Chromatography B ◽

10.1016/j.jchromb.2007.07.029 ◽

2007 ◽

Vol 857 (2) ◽

pp. 266-274 ◽

Cited By ~ 11

Author(s):

Zong-ling Xia ◽

Jing-yan Ying ◽

Rong Sheng ◽

Su Zeng ◽

Yong-zhou Hu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Spectrometry Method ◽

Mass Spectrometry Method

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Characterization of the in vivo and in vitro metabolic profile of PAC-1 using liquid chromatography–mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2008.10.006 ◽

2008 ◽

Vol 876 (1) ◽

pp. 47-53 ◽

Cited By ~ 15

Author(s):

Lei Ren ◽

Kaishun Bi ◽

Ping Gong ◽

Weiming Cheng ◽

Zhen Song ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Metabolic Profile ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2017.01.027 ◽

2017 ◽

Vol 101 ◽

pp. 80-89 ◽

Cited By ~ 8

Author(s):

Raghava Choudary Palacharla ◽

Venkatesham Uthukam ◽

Arunkumar Manoharan ◽

Ranjith Kumar Ponnamaneni ◽

Nagasurya Prakash Padala ◽

...

Keyword(s):

Fatty Acids ◽

Human Liver ◽

Unsaturated Fatty Acids ◽

Liver Microsomes ◽

Hepatic Clearance ◽

Cytochrome P450 Enzymes ◽

In Vivo Extrapolation

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Metabolite identification studies on amiodarone in in vitro (rat liver microsomes, rat and human liver S9 fractions) and in vivo (rat feces, urine, plasma) matrices by using liquid chromatography with high-resolution mass spectrometry and multiple-stage m

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6787 ◽

2013 ◽

Vol 28 (4) ◽

pp. 311-331 ◽

Cited By ~ 16

Author(s):

Ninad Ramesh Varkhede ◽

Shalu Jhajra ◽

Deepak Suresh Ahire ◽

Saranjit Singh

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

High Resolution Mass Spectrometry ◽

Liver Microsomes ◽

Metabolite Identification ◽

Rat Liver Microsomes ◽

Resolution Mass

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Identification of Gemfibrozil Metabolites, Produced as Positional Isomers in Human Liver Microsomes, by On-line Analyses Using Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Nuclear Magnetic Resonance Spectroscopy

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.52.277 ◽

2004 ◽

Vol 52 (5) ◽

pp. 277-283 ◽

Cited By ~ 9

Author(s):

Takahiro MURAI ◽

Haruo IWABUCHI ◽

Toshihiko IKEDA

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Human Liver ◽

Liver Microsomes ◽

Resonance Spectroscopy ◽

Positional Isomers ◽

Liquid Chromatography Mass Spectrometry ◽

On Line

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Characterization by Liquid Chromatography-Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-Mass Spectrometry of Two Coupled Oxidative-Conjugative Metabolic Pathways for 7-Ethoxycoumarin in Human Liver Microsomes Treated with Alamethicin

Drug Metabolism and Disposition ◽

10.1124/dmd.30.3.270 ◽

2002 ◽

Vol 30 (3) ◽

pp. 270-275 ◽

Cited By ~ 14

Author(s):

Michael B. Fisher ◽

David Jackson ◽

Andreas Kaerner ◽

Steven A. Wrighton ◽

Anthony G. Borel

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Metabolic Pathways ◽

Human Liver ◽

Liver Microsomes ◽

Resonance Spectroscopy ◽

Liquid Chromatography Mass Spectrometry

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