Microwave Detection of Metastasized Breast Cancer Cells in the Lymph Node; Potential Application for Sentinel Lymphadenectomy

2004 ◽  
Vol 86 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Jin Wook Choi ◽  
Jeiwon Cho ◽  
Yangsoo Lee ◽  
Jounghwa Yim ◽  
Byoungjoong Kang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Cells ◽  
Potential Application ◽  
Breast Cancer Cells ◽  
Sentinel Lymphadenectomy ◽  
Microwave Detection ◽  
Node Potential

scholarly journals Non-Sentinel Lymph Node Metastases Associated With Isolated Breast Cancer Cells in the Sentinel Node

2008 ◽  
Vol 100 (22) ◽  
pp. 1574-1580 ◽  
Author(s):  
C. H. M. van Deurzen ◽  
M. de Boer ◽  
E. M. Monninkhof ◽  
P. Bult ◽  
E. van der Wall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Node ◽  
Cancer Cells ◽  
Lymph Node Metastases ◽  
Breast Cancer Cells ◽  
Node Metastases

scholarly journals Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

2010 ◽  
Vol 207 (11) ◽  
pp. 2421-2437 ◽  
Author(s):  
Yingjie Xu ◽  
Tarek A. Bismar ◽  
Jie Su ◽  
Bin Xu ◽  
Glen Kristiansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Lymph Node ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Breast Cancer Cells ◽  
Cancer Cell Migration ◽  
Filamin A ◽  
Down Regulation

The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study, we report that FLNa suppresses invasion of breast cancer cells and regulates focal adhesion (FA) turnover. Two large progression tissue microarrays from breast cancer patients revealed a significant decrease of FLNa levels in tissues from invasive breast cancer compared with benign disease and in lymph node–positive compared with lymph node–negative breast cancer. In breast cancer cells and orthotopic mouse breast cancer models, down-regulation of FLNa stimulated cancer cell migration, invasion, and metastasis formation. Time-lapse microscopy and biochemical assays after FLNa silencing and rescue with wild-type or mutant protein resistant to calpain cleavage revealed that FLNa regulates FA disassembly at the leading edge of motile cells. Moreover, FLNa down-regulation enhanced calpain activity through the mitogen-activated protein kinase–extracellular signal-regulated kinase cascade and stimulated the cleavage of FA proteins. These results document a regulation of FA dynamics by FLNa in breast cancer cells.

Overexpression of Bcl-xL in Human Breast Cancer Cells Enhances Organ-Selective Lymph Node Metastasis

2004 ◽  
Vol 87 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Laura España ◽  
Yolanda Fernández ◽  
Nuria Rubio ◽  
Angels Torregrosa ◽  
Jeronimo Blanco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Node Metastasis

An ESIPT based chromogenic and fluorescent ratiometric probe for Zn2+ with imaging in live cells and tissues

2019 ◽  
Vol 43 (4) ◽  
pp. 1857-1863 ◽  
Author(s):  
Saswati Gharami ◽  
Krishnendu Aich ◽  
Deblina Sarkar ◽  
Paramita Ghosh ◽  
Nabendu Murmu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Potential Application ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Live Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Efficient Detection ◽  
Ratiometric Probe

A benzothiazole based fluorescent probe for selective and efficient detection of Zn2+ showing potential application in human breast cancer cells.

scholarly journals Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Huikun Zhang ◽  
Zhifang Guo ◽  
Xiaoli Liu ◽  
Yawen Zhao ◽  
Yongzi Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Replication ◽  
Cancer Cells ◽  
Nuclear Export ◽  
Potential Application ◽  
Breast Cancer Cells ◽  
Gene Knockout ◽  
Dna Helicase ◽  
Migration And Invasion ◽  
Endocytic Protein

AbstractBreast cancer is the most common type of cancer worldwide. However, the well-known molecular biomarkers are not enough to meet the needs of precision medicine. In search for novel targets in this regard, we reported ITSN1 (intersectin1) as one of the candidates through mRNA microarray analysis. In the present study, we reported that endocytic protein ITSN1-S exists not only in the cytoplasm but also in nuclei of breast cancer cells. ITSN1-S′ functional nuclear localization signal is within its residues 306–312. Its nuclear export signal (NES) resides within its SH3 domains. We also found, the interaction between the CC domain of nuclear ITSN1-S and the NT domain of nuclear DNA helicase II (NDH II) directly suppressed the DNA replication and nascent DNA synthesis by inhibiting the R-loops resolution in breast cancer cells. Furthermore, the interaction between the EH domains of cytoplasmic ITSN1-S and PI3KC2α inhibit cell migration and invasion by inactivating the PI3KC2α-AKT pathway. Our results were confirmed in both ITSN1 gene knockout cells and in vivo assays. Finally, our clinical data showed a potential application of the combined consideration of the cytoplasmic and nuclear ITSN1-S as an independent prognosis factor. In conclusion, our study revealed ITSN1-S′ novel positioning in the nuclei of breast cancer cells, its function in suppressing DNA replication, and its potential application in improved breast cancer prognosis.

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