Autismus-Spektrum-Symptome bei Kindern mit Geburtsblindheit

2020 ◽  
Vol 48 (4) ◽  
pp. 289-302
Author(s):  
Kilian Pankert ◽  
Azarakhsh Pankert ◽  
Leon David Lotter ◽  
Beate Herpertz-Dahlmann ◽  
Kerstin Konrad
Keyword(s):  
Gold Standard ◽  
Social Responsiveness Scale ◽  
Social Responsiveness

Zusammenfassung. Fragestellung: Kinder mit Beeinträchtigungen des Sehens (BS) zeigten in einigen Untersuchungen autismusähnliche Verhaltensweisen. Die Anwendung vorhandener diagnostischer Screening-Instrumente für Autismus-Spektrum-Störungen (ASS) ist problematisch, da diese in der Regel ein intaktes Sehvermögen voraussetzen. Ziel dieser explorativen Studie war es, die prinzipielle Anwendbarkeit von drei ASS-Screening-Fragebögen bei Kindern mit Geburtsblindheit zu überprüfen. Methodik: 15 Kinder mit Geburtsblindheit, 15 Kinder mit ASS (ohne BS) und 20 Kontrollprobandinnen und –probanden wurden mittels des „Fragebogens zur Sozialen Kommunikation“ (FSK), der „Marburger Beurteilungsskala zum Asperger-Syndrom“ (MBAS) und der „Social Responsiveness Scale“ (SRS) untersucht. Ergebnisse: Items, die motorische oder mimisch-gestische Auffälligkeiten und geteilte Aufmerksamkeit erfassten, wurden bei Kindern mit Geburtsblindheit häufig als auffällig beschrieben. Insgesamt zeigten diese Kinder in den ASS-Screening-Instrumenten höhere Werte als Kontrollpersonen, aber meist niedrigere Werte als sehende Kinder mit ASS. Je nach Fragebogen erreichten zwischen 23 und 67 % der Stichprobe mit Geburtsblindheit den klinischen Cut-Off-Wert für ASS. In dieser Gruppe korrelierte der SRS-Gesamtwert negativ mit der kognitiven Empathie und der verbalen Intelligenz. Schlussfolgerungen: Mütter von Kindern mit BS beschreiben in ASS-Screening-Instrumenten vermehrt ASS-Symptome. Dies könnte auf einer ausgeprägten Symptomüberschneidung von ASS und Blindheit beruhen. ASS-Screeningverfahren sollten zukünftig an die spezifischen Besonderheiten von Personen mit beeinträchtigten visuellen Fähigkeiten angepasst und mit Gold-Standard-Methoden validiert werden.

Social impairment in children with epilepsy assessed by the social responsiveness scale

2021 ◽  
pp. 135910452110331
Author(s):  
Samah K Aburahma ◽  
Hanan Hammouri ◽  
Ethar Hazaimeh ◽  
Omar Jbarah ◽  
Ahmad Nassar ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Social Responsiveness Scale ◽  
Social Impairment ◽  
Control Group ◽  
Social Responsiveness ◽  
Healthy Children ◽  
Normal Children ◽  
Social Impairments ◽  
Increased Risk ◽  
The Social

Children with epilepsy are at risk for impaired social cognition and autism. We aimed at evaluating the utility of the social responsiveness scale (SRS) for assessment of social impairment in these children. Prospective study; the SRS was applied to a group of children with epilepsy and a healthy control group. Intellectual disability in the epilepsy group was assessed utilizing adapted versions of the Wechsler Intelligence and adaptive behavior scales. One hundred and one children with epilepsy and 92 healthy children were included. The majority of children in both groups had normal SRS scores. Significant differences were identified in children with high total scores indicating significant deficiencies in reciprocal social behavior; high scores were found in 16% of children with epilepsy versus 7% of normal children, p < .05, particularly involving social communication, p < .05. Intellectual disability was identified in 42% of children with epilepsy, particularly processing speed index, p < .001. Intellectual disability had a significant effect on total scores, p = .016. Children with epilepsy have increased risk of social impairments. Social impairments are more likely in the presence of intellectual disability. The SRS is a quick identification tool that can be employed in the outpatient setting.

scholarly journals Modifying and validating the social responsiveness scale edition 2 for use with deaf children and young people

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243162
Author(s):  
Barry Wright ◽  
Helen Phillips ◽  
Ann Le Couteur ◽  
Jennifer Sweetman ◽  
Rachel Hodkinson ◽  
...  
Keyword(s):  
Sign Language ◽  
Intraclass Correlation ◽  
Autism Spectrum ◽  
Social Responsiveness Scale ◽  
Deaf Children ◽  
Social Responsiveness ◽  
Deaf People ◽  
Delphi Consensus ◽  
The Social ◽  
Test Retest Reliability

A Delphi consensus methodology was used to adapt a screening tool, the Social Responsiveness Scale– 2 (SRS-2), for use with deaf children including those whose preferred communication method is sign language. Using this approach; 27 international experts (The Delphi International Expert Panel), on the topic of autism spectrum disorder (ASD) in deaf people, contributed to the review of item content. A criterion for agreement was set at 80% of experts on each item (with 75% acceptable in the final fourth round). The agreed modifications are discussed. The modified SRS-2 research adaptation for deaf people (referred to here as the “SRS-2 Deaf adaptation”) was then translated into British Sign Language using a robust translation methodology and validated in England in a sample of 198 deaf children, 76 with Autism Spectrum Disorders (ASD) and 122 without ASD. The SRS-2 Deaf adaptation was compared blind to a NICE (National Institute for Health and Care Excellence) guideline standard clinical assessment. The area under the Receiver Operating (ROC) curve was 0.811 (95% CI: 0.753, 0.869), with an optimal cut-off value of 73, which gave a sensitivity of 82% and a specificity of 67%. The Cronbach Alpha coefficient was 0.968 suggesting high internal consistency. The Intraclass Correlation Coefficient was 0.897, supporting test-retest reliability. This performance is equivalent to similar instruments used for screening ASD in the hearing population.

scholarly journals Psychometric properties of the Chinese version of the Social Responsiveness Scale

2013 ◽  
Vol 7 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Susan Shur-Fen Gau ◽  
Li-Ting Liu ◽  
Yu-Yu Wu ◽  
Yen-Nan Chiu ◽  
Wen-Che Tsai
Keyword(s):  
Psychometric Properties ◽  
Social Responsiveness Scale ◽  
Chinese Version ◽  
Social Responsiveness ◽  
The Social

ASD Screening Measures for High-Ability Youth With ASD: Examining the ASSQ and SRS

2018 ◽  
Vol 62 (2) ◽  
pp. 220-229 ◽  
Author(s):  
Charles D. Cederberg ◽  
Lianne C. Gann ◽  
Megan Foley-Nicpon ◽  
Zachary Sussman
Keyword(s):  
Autism Spectrum ◽  
Social Responsiveness Scale ◽  
Intervention Strategies ◽  
Screening Tools ◽  
Social Responsiveness ◽  
High Ability ◽  
Research And Practice ◽  
Phenotypic Differences ◽  
High Ability Students ◽  
Screening Measures

High-ability youth diagnosed with autism spectrum disorder (ASD) historically have been neglected within samples validating ASD screening measures, and consensus for what constitutes high ability has not been established. The Autism Spectrum Screening Questionnaire (ASSQ) and Social Responsiveness Scale (SRS) are two common screening tools for ASD used within research and practice settings. We investigated the accuracy of the ASSQ and SRS for ASD identification among a sample of 23 high-ability youth previously diagnosed with ASD. Results suggest both ASSQ and SRS measures inconsistently screened for ASD. The high-ability students with ASD scored significantly lower on the SRS total score and social cognition, communication, and motivation subscales, suggesting potential phenotypic differences among high-ability youth with ASD that could inform assessment and intervention strategies.

Social Responsiveness Scale for Adults--Japanese Version

2014 ◽  
Author(s):  
Reiko Takei ◽  
Junko Matsuo ◽  
Hidetoshi Takahashi ◽  
Tokio Uchiyama ◽  
Hiroshi Kunugi ◽  
...  
Keyword(s):  
Japanese Version ◽  
Social Responsiveness Scale ◽  
Social Responsiveness

Use of social responsiveness scale in Taiwanese adolescents

2012 ◽  
Vol 60 (5) ◽  
pp. S214
Author(s):  
Y. Chen ◽  
J. Hsu ◽  
K.L. Huang ◽  
C.C. Liu ◽  
C. Lan
Keyword(s):  
Social Responsiveness Scale ◽  
Social Responsiveness

scholarly journals Efficacy and safety of memantine in children with autism spectrum disorder: Results from three phase 2 multicenter studies

Autism ◽  
2019 ◽  
Vol 23 (8) ◽  
pp. 2096-2111 ◽  
Author(s):  
Antonio Y Hardan ◽  
Robert L Hendren ◽  
Michael G Aman ◽  
Adelaide Robb ◽  
Raun D Melmed ◽  
...  
Keyword(s):  
Extended Release ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Social Responsiveness Scale ◽  
Social Responsiveness ◽  
Phase 2 ◽  
Open Label ◽  
Double Blind ◽  
Three Phase ◽  
Open Label Trial

Three phase 2 trials were conducted to assess the efficacy and long-term safety of weight-based memantine extended release (ER) treatment in children with autism spectrum disorder. MEM-MD-91, a 50-week open-label trial, identified memantine extended-release treatment responders for enrollment into MEM-MD-68, a 12-week randomized, double-blind, placebo-controlled withdrawal trial. MEM-MD-69 was an open-label extension trial in which participants from MEM-MD-68, MEM-MD-91, and open-label trial MEM-MD-67 were treated ⩽48 weeks with memantine extended release. In MEM-MD-91, 517 (59.6%) participants were confirmed Social Responsiveness Scale responders at week 12; mean Social Responsiveness Scale total raw scores improved two to three times a minimal clinically important difference of 10 points. In MEM-MD-68, there was no difference between memantine and placebo on the primary efficacy parameter, the proportion of patients with a loss of therapeutic response (defined as ⩾10-point increase from baseline in Social Responsiveness Scale total raw score). MEM-MD-69 exploratory analyses revealed mean standard deviation improvement in Social Responsiveness Scale total raw score of 32.4 (26.4) from baseline of the first lead-in study. No new safety concerns were evident. While the a priori–defined efficacy results of the double-blind trial were not achieved, the considerable improvements in mean Social Responsiveness Scale scores from baseline in the open-label trials were presumed to be clinically important.

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