Social impairment in children with epilepsy assessed by the social responsiveness scale

2021 ◽  
pp. 135910452110331
Author(s):  
Samah K Aburahma ◽  
Hanan Hammouri ◽  
Ethar Hazaimeh ◽  
Omar Jbarah ◽  
Ahmad Nassar ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Social Responsiveness Scale ◽  
Social Impairment ◽  
Control Group ◽  
Social Responsiveness ◽  
Healthy Children ◽  
Normal Children ◽  
Social Impairments ◽  
Increased Risk ◽  
The Social

Children with epilepsy are at risk for impaired social cognition and autism. We aimed at evaluating the utility of the social responsiveness scale (SRS) for assessment of social impairment in these children. Prospective study; the SRS was applied to a group of children with epilepsy and a healthy control group. Intellectual disability in the epilepsy group was assessed utilizing adapted versions of the Wechsler Intelligence and adaptive behavior scales. One hundred and one children with epilepsy and 92 healthy children were included. The majority of children in both groups had normal SRS scores. Significant differences were identified in children with high total scores indicating significant deficiencies in reciprocal social behavior; high scores were found in 16% of children with epilepsy versus 7% of normal children, p < .05, particularly involving social communication, p < .05. Intellectual disability was identified in 42% of children with epilepsy, particularly processing speed index, p < .001. Intellectual disability had a significant effect on total scores, p = .016. Children with epilepsy have increased risk of social impairments. Social impairments are more likely in the presence of intellectual disability. The SRS is a quick identification tool that can be employed in the outpatient setting.

scholarly journals Modifying and validating the social responsiveness scale edition 2 for use with deaf children and young people

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243162
Author(s):  
Barry Wright ◽  
Helen Phillips ◽  
Ann Le Couteur ◽  
Jennifer Sweetman ◽  
Rachel Hodkinson ◽  
...  
Keyword(s):  
Sign Language ◽  
Intraclass Correlation ◽  
Autism Spectrum ◽  
Social Responsiveness Scale ◽  
Deaf Children ◽  
Social Responsiveness ◽  
Deaf People ◽  
Delphi Consensus ◽  
The Social ◽  
Test Retest Reliability

A Delphi consensus methodology was used to adapt a screening tool, the Social Responsiveness Scale– 2 (SRS-2), for use with deaf children including those whose preferred communication method is sign language. Using this approach; 27 international experts (The Delphi International Expert Panel), on the topic of autism spectrum disorder (ASD) in deaf people, contributed to the review of item content. A criterion for agreement was set at 80% of experts on each item (with 75% acceptable in the final fourth round). The agreed modifications are discussed. The modified SRS-2 research adaptation for deaf people (referred to here as the “SRS-2 Deaf adaptation”) was then translated into British Sign Language using a robust translation methodology and validated in England in a sample of 198 deaf children, 76 with Autism Spectrum Disorders (ASD) and 122 without ASD. The SRS-2 Deaf adaptation was compared blind to a NICE (National Institute for Health and Care Excellence) guideline standard clinical assessment. The area under the Receiver Operating (ROC) curve was 0.811 (95% CI: 0.753, 0.869), with an optimal cut-off value of 73, which gave a sensitivity of 82% and a specificity of 67%. The Cronbach Alpha coefficient was 0.968 suggesting high internal consistency. The Intraclass Correlation Coefficient was 0.897, supporting test-retest reliability. This performance is equivalent to similar instruments used for screening ASD in the hearing population.

scholarly journals Psychometric properties of the Chinese version of the Social Responsiveness Scale

2013 ◽  
Vol 7 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Susan Shur-Fen Gau ◽  
Li-Ting Liu ◽  
Yu-Yu Wu ◽  
Yen-Nan Chiu ◽  
Wen-Che Tsai
Keyword(s):  
Psychometric Properties ◽  
Social Responsiveness Scale ◽  
Chinese Version ◽  
Social Responsiveness ◽  
The Social

QT dispersion in acute rheumatic fever

2006 ◽  
Vol 16 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Tugcin Bora Polat ◽  
Yalim Yalcin ◽  
Celal Akdeniz ◽  
Cenap Zeybek ◽  
Abdullah Erdem ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Qt Dispersion ◽  
Control Group ◽  
Healthy Children ◽  
Rheumatic Carditis ◽  
Normal Children ◽  
A Value ◽  
The Mean

Background:Disturbances of conduction are well known in the setting of acute rheumatic fever. The aim of this study is to investigate the QT dispersion as seen in the surface electrocardiogram of children with acute rheumatic fever.Methods:QT dispersion was quantitatively evaluated in 88 children with acute rheumatic fever. Patients were divided into two groups based on the absence or presence of carditis. As a control group, we studied 36 healthy children free of any disease, and matched for age with both groups. Repeat echocardiographic examinations were routinely scheduled in all patients at 3 months after the initial attack to study the evolution of valvar lesions.Results:The mean QT dispersion was significantly higher in children with rheumatic carditis. But there was no statistical difference between children without carditis and normal children. Among the children with carditis, the mean dispersion was higher in those with significant valvar regurgitation. Dispersion of greater than 55 milliseconds had a sensitivity of 85%, and specificity of 70%, in predicting rheumatic carditis, while a value of 65 milliseconds or greater had sensitivity of 81% specificity of 85% in predicting severe valvar lesions in acute rheumatic carditis. At follow-up examination, a clear reduction on the QT dispersion was the main finding, reflecting an electrophysiological improvement.Conclusions:These observations suggest that QT dispersion is increased in association with cardiac involvement in children with acute rheumatic fever.

P wave dispersion, Tpeak–Tend interval, and Tp-e/QT ratio in children with psoriasis

2020 ◽  
Vol 30 (3) ◽  
pp. 318-322
Author(s):  
Mecnun Çetin ◽  
İbrahim H. Yavuz ◽  
Mehmet Gümüştaş ◽  
Göknur Ö. Yavuz
Keyword(s):  
Wave Dispersion ◽  
P Wave ◽  
Cardiac Conduction ◽  
Control Group ◽  
Healthy Children ◽  
P Wave Dispersion ◽  
System Disease ◽  
Increased Risk ◽  
Electrocardiographic Parameters ◽  
Key Indicators

AbstractBackground:Psoriasis is a chronic inflammatory, multi-system disease that often begins in childhood and characterised by inflammatory skin, nails, scalp, and joint manifestations. The inflammation in psoriasis may promote some effect on the cardiac conduction system.Objective:The aim of this study is to investigate myocardial repolarisation anomaly on the conducting system in the paediatric psoriasis using P wave dispersion, Tpeak–Tend interval, and Tp-e/QT ratio.Methods:Forty-two patients diagnosed with psoriasis and 37 age- and sex-matched healthy children were enrolled in the study. Electrocardiographic parameters in psoriasis and control group were recorded from an electrocardiogram for each patient.Results:The results indicated that the parameters including Pdis, QTc dis, Tp-e dis interval, and Tp-e max/QTmax ratios, which are known to be key indicators for the prediction of severe atrial or ventricular arrhythmia and sudden cardiac death and also important parameters used as the indicators for the non-invasive evaluation of the transmural heterogeneity were significantly longer in the study group compared to the control group (p < 0.05).Conclusions:This study includes the evidence linking psoriasis with increased myocardial repolarisation heterogeneity. These findings suggest that this patient population may be at an increased risk for arrhythmias. Our findings may be a basis for further studies.

scholarly journals Gene discoveries in autism are biased towards comorbidity with intellectual disability

2020 ◽  
Vol 57 (9) ◽  
pp. 647-652
Author(s):  
Matthew Jensen ◽  
Corrine Smolen ◽  
Santhosh Girirajan
Keyword(s):  
Intellectual Disability ◽  
Genetic Factors ◽  
De Novo ◽  
High Functioning Autism ◽  
Copy Number Variants ◽  
Social Responsiveness ◽  
High Functioning ◽  
Pathogenic Variants ◽  
Increased Risk ◽  
Normal Cognitive Function

BackgroundAutism typically presents with highly heterogeneous features, including frequent comorbidity with intellectual disability (ID). The overlap between these phenotypes has confounded the diagnosis and discovery of genetic factors associated with autism. We analysed pathogenic de novo genetic variants in individuals with autism who had either ID or normal cognitive function to determine whether genes associated with autism also contribute towards ID comorbidity.MethodsWe analysed 2290 individuals from the Simons Simplex Collection for de novo likely gene-disruptive (LGD) variants and copy-number variants (CNVs), and determined their relevance towards IQ and Social Responsiveness Scale (SRS) measures.ResultsIndividuals who carried de novo variants in a set of 173 autism-associated genes showed an average 12.8-point decrease in IQ scores (p=5.49×10−6) and 2.8-point increase in SRS scores (p=0.013) compared with individuals without such variants. Furthermore, individuals with high-functioning autism (IQ >100) had lower frequencies of de novo LGD variants (42 of 397 vs 86 of 562, p=0.021) and CNVs (9 of 397 vs 24 of 562, p=0.065) compared with individuals who manifested both autism and ID (IQ <70). Pathogenic variants disrupting autism-associated genes conferred a 4.85-fold increased risk (p=0.011) for comorbid ID, while de novo variants observed in individuals with high-functioning autism disrupted genes with little functional relevance towards neurodevelopment.ConclusionsPathogenic de novo variants disrupting autism-associated genes contribute towards autism and ID comorbidity, while other genetic factors are likely to be causal for high-functioning autism.

scholarly journals Validating the social responsiveness scale for adults with autism

2017 ◽  
Vol 10 (10) ◽  
pp. 1663-1671 ◽  
Author(s):  
Wai Chan ◽  
Leann E. Smith ◽  
Jinkuk Hong ◽  
Jan S. Greenberg ◽  
Marsha R. Mailick
Keyword(s):  
Social Responsiveness Scale ◽  
Social Responsiveness ◽  
Adults With Autism ◽  
The Social
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