Role of Interleukin 10- Producing T Cells in Specific (Allergen) Immunotherapy

2000 ◽  
Vol 12 (1) ◽  
pp. 0020-0025 ◽  
Author(s):  
Iris Bellinghausen ◽  
Jürgen Knop ◽  
Joachim Saloga
Keyword(s):  
T Cells ◽  
Allergen Immunotherapy ◽  
Interleukin 10 ◽  
Specific Allergen

scholarly journals Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Mamoru Niikura ◽  
Shin-Ichi Inoue ◽  
Fumie Kobayashi
Keyword(s):  
Innate Immunity ◽  
T Cells ◽  
Immune Responses ◽  
Malaria Infection ◽  
Inflammatory Cytokine ◽  
Interleukin 10 ◽  
Malaria Parasites ◽  
Severe Pathology ◽  
Anti Inflammatory Cytokine

Interleukin- (IL-) 10, anti-inflammatory cytokine, is known to inhibit the protective immune responses against malaria parasites and to be involved in exacerbating parasitemia duringPlasmodiuminfection. In contrast, IL-10 is regarded as necessary for suppressing severe pathology duringPlasmodiuminfection. Here, we summarize the role of IL-10 during murine malaria infection, focusing especially on coinfection with lethal and nonlethal strains of malaria parasites. Recent studies have demonstrated that the major sources of IL-10 are subpopulations of CD4+T cells in humans and mice infected withPlasmodium. We also discuss the influence of innate immunity on the induction of CD4+T cells during murine malaria coinfection.

Regulatory role of antigen-induced interleukin-10, produced by CD4+ T cells, in airway neutrophilia in a murine model for asthma

2012 ◽  
Vol 677 (1-3) ◽  
pp. 154-162 ◽  
Author(s):  
Takeshi Nabe ◽  
Ayumu Ikedo ◽  
Fusa Hosokawa ◽  
Maki Kishima ◽  
Masanori Fujii ◽  
...  
Keyword(s):  
T Cells ◽  
Murine Model ◽  
Cd4 T Cells ◽  
Interleukin 10 ◽  
Regulatory Role

scholarly journals Specific immunotherapy for allergic diseases

2016 ◽  
Vol 45 (4) ◽  
pp. 137
Author(s):  
Ariyanto Harsono
Keyword(s):  
19Th Century ◽  
Allergen Immunotherapy ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Basic Principles ◽  
The 19Th Century ◽  
Careful Assessment ◽  
Specific Allergen

Specific allergen immunotherapy (SIT)involves the administration of allergenextracts to modify or abolish symptomsassociated with atopic allergy. The process isspecific, in that the treatment is targeted at thoseallergens recognized by the patient and physician asresponsible for symptoms. A decision to use SITtherefore demands a careful assessment of the patient’scondition and the role of allergic triggers.Immunotherapy was first developed at St Mary’sHospital, London at the end of the 19th century, andmany of the basic principles remain valid today.

scholarly journals Increased regulatory B cells are involved in immune evasion in patients with gastric cancer

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yuki Murakami ◽  
Hiroaki Saito ◽  
Shota Shimizu ◽  
Yusuke Kono ◽  
Yuji Shishido ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
B Cells ◽  
Immune Evasion ◽  
Survival Rates ◽  
Prognostic Indicator ◽  
Interleukin 10 ◽  
Regulatory B Cells ◽  
Carboxyfluorescein Succinimidyl Ester

Abstract Accumulating evidence has indicated that immune regulatory cells are involved in the establishment of tumoral immune evasion. However, the role of regulatory B cells (Bregs) in this remains unclear. Here, we identified a role for Bregs in immune evasion in gastric cancer (GC) patients. The frequency of peripheral Bregs was significantly higher in GC patients than in healthy controls (P = 0.0023). Moreover, the frequency of CD19+CD24hiCD27+ B cells in GC tissue was significantly higher than in peripheral blood and healthy gastric tissue. Carboxyfluorescein succinimidyl ester labeling revealed that CD19+CD24hiCD27+ B cells could suppress the proliferation of autologous CD4+ T cells. Moreover, CD19+CD24hiCD27+ B cells inhibited the production of interferon-gamma by CD4+ T cells. Double staining immunohistochemistry of interleukin-10 and CD19 revealed 5-year overall survival rates of 65.4% and 13.3% in BregLow and BregHigh groups, respectively (P < 0.0001). Multivariate analysis indicated that the frequency of Bregs was an independent prognostic indicator in GC patients. Taken together, our results show the existence of Bregs in GC tissue, and indicate that they are significantly correlated with the prognosis of GC patients.

Sign in / Sign up

Export Citation Format

Share Document