scholarly journals Mapping asperities by minima of local recurrence time: San Jacinto-Elsinore fault zones

2000 ◽  
Vol 105 (B4) ◽  
pp. 7829-7844 ◽  
Author(s):  
Max Wyss ◽  
Danijel Schorlemmer ◽  
Stefan Wiemer
Keyword(s):  
Local Recurrence ◽  
Fault Zones ◽  
Recurrence Time

scholarly journals Numerical Modelling of Lithospheric Block-and-Fault Dynamics: What Did We Learn About Large Earthquake Occurrences and Their Frequency?

2022 ◽  
Author(s):  
Alik Ismail-Zadeh ◽  
Alexander Soloviev
Keyword(s):  
Numerical Modelling ◽  
Driving Forces ◽  
Fault Zones ◽  
Stress Generation ◽  
Plate Motion ◽  
Recurrence Time ◽  
Key Factors ◽  
Fault Dynamics ◽  
Dynamics Models ◽  
Large Earthquakes

AbstractDynamics of lithospheric plates resulting in localisation of tectonic stresses and their release in large earthquakes provides important information for seismic hazard assessments. Numerical modelling of the dynamics and earthquake simulations have been changing our view about occurrences of large earthquakes in a system of major regional faults and about the recurrence time of the earthquakes. Here, we overview quantitative models of tectonic stress generation and stress transfer, models of dynamic systems reproducing basic features of seismicity, and fault dynamics models. Then, we review the thirty-year efforts in the modelling of lithospheric block-and-fault dynamics, which allowed us to better understand how the blocks react to the plate motion, how stresses are localised and released in earthquakes, how rheological properties of fault zones exert influence on the earthquake dynamics, where large seismic events occur, and what is the recurrence time of these events. A few key factors influencing the earthquake sequences, clustering, and magnitude are identified including lithospheric plate driving forces, the geometry of fault zones, and their physical properties. We illustrate the effects of the key factors by analysing the block-and-fault dynamics models applied to several earthquake-prone regions, such as Carpathians, Caucasus, Tibet-Himalaya, and the Sunda arc, as well as to the global tectonic plate dynamics.

scholarly journals CT-based Radiomic Analysis for Prediction of Treatment Response of Salvage Chemoradiotherapy for Loco-regional Lymph Node Recurrence After Curative Esophagectomy

2021 ◽  
Author(s):  
Liang Gu ◽  
Xinwei Guo ◽  
Hongxue Ye ◽  
Shaobin Zhou ◽  
Yangchen Liu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Local Recurrence ◽  
Treatment Response ◽  
Local Control ◽  
Therapeutic Response ◽  
Recurrence Time ◽  
Training Cohort ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
Curative Esophagectomy

Abstract Objective: To investigate the capability of computed tomography (CT) radiomic features to predict the therapeutic response and local control of the loco-regional recurrence lymph node (LN) after curative esophagectomy by chemoradiotherapy (CRT).Methods: This retrospective study included 129 LN from 77 patients (training cohort: 102 LN from 59 patients; validation cohort: 27 LN from 18 patients) with postoperative esophageal squamous cell carcinoma (ESCC). The region of the tumor was contoured in pretreatment contrast-enhanced CT images. The least absolute shrinkage and selection operator (LASSO) with logistic regression was used to identify radiomic predictors in the training cohort. Model performance was evaluated using the area under the receiver operating characteristic curves (AUC). The Kaplan-Meier method was used to determine the local recurrence time of cancer.Results: Seven features were selected to construct a radiomics model for predicting therapeutic response. The AUCs in the training and validated cohorts were 0.777 (95%CI: 0.667–0.878) and 0.765(95%CI: 0.556–0.975), respectively. A significant difference of radiomic score (Rad-score) between the response and non-response was observed in the two cohorts (P < 0.001, 0.034, respectively). Two features were identified for classifying whether to relapse in two years. AUC was 0.857(95%CI: 0.780–0.935) in the training cohort. The local control time of the high Rad-score group was higher than the low group in both cohorts (P < 0.001 and 0.025, respectively). After the Cox regression analysis, the Rad-score indicated high-risk factors for local recurrence within two years.Conclusions: The radiomics approach can be used as a potential imaging biomarker to predict treatment response and local control of recurrence LN in ESCC patients.

Outcome of leiomyosarcoma of bone: A single center experience.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e21502-e21502
Author(s):  
Rajeev Rajendra ◽  
Seth Pollack ◽  
Eve T. Rodler ◽  
Ernest U. Conrad ◽  
Darin J Davidson ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Neoadjuvant Chemotherapy ◽  
Surgical Resection ◽  
Treatment Strategies ◽  
Recurrence Time ◽  
Low Grade ◽  
High Grade ◽  
Response To Chemotherapy

e21502 Background: Leiomyosarcoma (LMS) of bone is a very rare sarcoma subtype. These tumors are managed akin to osteosarcoma, with neoadjuvant chemotherapy followed by surgery. The precise role of chemotherapy remains to be defined. Methods: Patients treated with primary bone LMS at the University of Washington between 2002 and 2012 were included. Patients with high grade tumors were treated with neoadjuvant chemotherapy and surgery; whereas those with low grade tumors were treated with surgical resection alone. Chemotherapy consisted of doxorubicin and ifosfamide x 2 cycles. Treatment details included: initial treatment (surgery versus chemo), surgical and pathological margins, and timing of chemotherapy. Follow-up data included: time to local recurrence, time to metastasis, time to last follow up if alive, or time to death. Results: Ten patients were identified, 4 male and 6 female. Median age at diagnosis: 52 years (range 29 - 91). The primary site was the distal femur in 5 patients, and the hemipelvis, acetabulum, proximal femur, distal clavicle and mid-shaft of femur in 1 patient each. Median tumor size at diagnosis was 8 cm. Five were high-grade tumors; 3 were intermediate and 2 were low grade. Four of 10 patients received neoadjuvant chemotherapy, with the following histological response; 70%, 30%, 15% and <5%. None of these patients had a dimensional radiological response to chemotherapy. Of the patients treated with surgery alone, one developed a local recurrence and another developed metastatic disease. Of the patients treated with chemotherapy and surgery, 1 died from an unrelated cause. Median follow-up was 9 months (range 0 - 83). Median DFS was 9 months (range 0 - 83). OS has not yet been reached. Conclusions: Surgical resection remains the mainstay of management of LMS of bone. The role of neoadjuvant chemotherapy requires further evaluation. Larger collaborative studies and biomarker analyses are essential to evaluate optimal treatment strategies for this rare disease.

Synovial Sarcoma: A Multivariate Analysis of Prognostic Factors in 112 Patients With Primary Localized Tumors of the Extremity

2000 ◽  
Vol 18 (10) ◽  
pp. 2087-2094 ◽  
Author(s):  
Jonathan J. Lewis ◽  
Cristina R. Antonescu ◽  
Denis H. Y. Leung ◽  
David Blumberg ◽  
John H. Healey ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Local Recurrence ◽  
Synovial Sarcoma ◽  
Tumor Size ◽  
Cox Regression ◽  
Distant Recurrence ◽  
Recurrence Time ◽  
Rank Test ◽  
End Points ◽  
Neurovascular Structures

PURPOSE: Synovial sarcoma is a high-grade tumor that is associated with poor prognosis. Previous studies analyzing prognostic factors are limited because of inclusion of heterogeneous cohorts of patients with nonextremity and recurrent tumors. The objective of this study was to determine independent prognostic factors of primary synovial sarcoma localized to the extremity. PATIENTS AND METHODS: Between July 1, 1982, and June 30, 1996, 112 patients underwent surgical resection for cure at our institution and then were followed-up prospectively. Clinical and pathologic factors examined for prognostic value included age, sex, tumor site and location, depth, size, microscopic status of surgical margins, invasion of bone or neurovascular structures, and monophasic or biphasic histology. The end points analyzed were the time to first local recurrence that was not preceded by a distant recurrence, time to any distant recurrence, and time to disease-related mortality. These end points were modeled using the method of Kaplan and Meier and analyzed by the log-rank test and Cox regression. RESULTS: The median duration of follow-up among survivors in this cohort of 112 patients was 72 months. The 5-year local-recurrence, distant-recurrence, and mortality rates were 12%, 39%, and 25%, respectively. Tumor size ≥ 5 cm (P = .001; relative risk [RR] = 2.7; 95% confidence interval [CI], 1.5 to 5.2) and the presence of bone or neurovascular invasion (P = .04; RR = 2.3; 95% CI, 1.0 to 5.3) were independent adverse predictors of distant recurrence. Tumor size ≥ 5 cm (P = .003; RR = 2.3; 95% CI, 1.4 to 6.3) and the presence of bone or neurovascular invasion (P = .03; RR = 2.7; 95% CI, 1.0 to 6.5) were also independent adverse predictors of mortality. CONCLUSION: The natural history of primary synovial sarcoma of the extremity is related to tumor size and invasion of bone and neurovascular structures.

scholarly journals Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

2017 ◽  
Vol 3 (2) ◽  
pp. 452 ◽  
Author(s):  
N. Dhaneshwar Singh ◽  
Kanwar Sen ◽  
Arun Sharma ◽  
Meenakshi Bharadwaj
Keyword(s):  
Local Recurrence ◽  
Vision Loss ◽  
Early Stage ◽  
External Beam Radiation ◽  
Recurrence Time ◽  
Radical Excision ◽  
Craniofacial Resection ◽  
Beam Radiation ◽  
Recurrent Epistaxis ◽  
Sinonasal Teratocarcinosarcoma

<p class="abstract">Sinonasal teratocarcinosarcoma (SNTCS) is a rare higly malignant tumour occuring almost exclusively in the sinonasal tract. This aggressive tumour arising from the primitive embryonic or immature pluripotential cells of olfactory epithelium has high propencity for loco-regional recurrence and mortality. SNTCS generally presents with relatively benign symptoms like nasal obstruction and recurrent epistaxis in its early stage. In advance stage with orbital and intracranial spread other symptoms raising suspicion of malignancy, such as dysphagia, odynophagia, epiphora, vision loss, exophthalmos, anosmia, headache and altered sensorium appears. In view of its aggressive behaviour, radical excision with or without chemoradiation is advocated as the optimum treatment. Local recurrence of SNTCS after excision has been reported as high as 45% with a mean recurrence time of 21.3 months. Even though distant metastasis is rare, local recurrence frequently leads to treatment failure and subsequent death. <span lang="EN-IN">Here we share our experience of SNTCS in a 23 year old male managed with endoscopic craniofacial resection followed by histocytology directed chemotherapy with external beam radiation. He remains disease free in last 3 years of follow up.</span></p><p> </p>

52: Clinical Relevance of Local Recurrence in Neobladders

2004 ◽  
Vol 171 (4S) ◽  
pp. 14-14
Author(s):  
Dieter R. Echtle ◽  
Elizabeth M. Mueller ◽  
Detlef H. Frohneberg
Keyword(s):  
Local Recurrence ◽  
Clinical Relevance

Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 76-77
Author(s):  
Mohd Athar ◽  
K S Sodhi ◽  
S Kala ◽  
R K Maurya ◽  
S Chauhan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Natural History ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

Sign in / Sign up

Export Citation Format

Share Document