Abstract. Floods and droughts are common, recurring natural hazards in East African nations. Studies of hydro-climatology at daily, seasonal, and annual time scale is an important in understanding and ultimately minimizing the impacts of such hazards. Using daily in-situ data over the last two decades combined with the recently available multiple-years satellite remote sensing data, we analyzed and simulated, with a distributed hydrologic model, the hydro-climatology in Nzoia, one of the major contributing sub-basins of Lake Victoria in the East African highlands. The basin, with a semi arid climate, has no sustained base flow contribution to Lake Victoria. The short spell of high discharge showed that rain is the prime cause of floods in the basin. There is only a marginal increase in annual mean discharge over the last 21 years. The 2-, 5- and 10-year peak discharges, for the entire study period showed that more years since the mid 1990's have had high peak discharges despite having relatively less annual rain. The study also presents the hydrologic model calibration and validation results over the Nzoia Basin. The spatiotemporal variability of the water cycle components were quantified using a physically-based, distributed hydrologic model, with in-situ and multi-satellite remote sensing datasets. Moreover, the hydrologic capability of remote sensing data such as TRMM-3B42V6 was tested in terms of reconstruction of the water cycle components. The spatial distribution and time series of modeling results for precipitation (P), evapotranspiration (ET), and change in storage (dS/dt) showed considerable agreement with the monthly model runoff estimates and gauge observations. Runoff values responded to precipitation events that occurred across the catchment during the wet season from March to early June. The hydrologic model captured the spatial variability of the soil moisture storage. The spatially distributed model inputs, states, and outputs, were found to be useful for understanding the hydrologic behavior at the catchment scale. Relatively high flows were experienced near the basin outlet from previous rainfall, with a new flood peak responding to the rainfall in the upper part of the basin. The monthly peak runoff was observed in the months of April, May and November. The analysis revealed a linear relationship between rainfall and runoff for both wet and dry seasons. The model was found to be useful in poorly gauged catchments using satellite forcing data and showed the potential to be used not only for the investigation of the catchment scale water balance but also for addressing issues pertaining to sustainability of the resources within the catchment.