Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets.

Abstract We recently identified a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), which is involved in energy homeostasis in birds and mammals. However, whether the action of NPGL is influenced by nutritional composition remains unknown. Thus, we investigated the effect of chronic intracerebroventricular infusion of NPGL for 13 days on feeding behavior and body mass gain under a normal chow diet (NC), high-fat diet, high-sucrose diet (HSD), and medium-fat/medium-sucrose diet (MFSD) in rats. NPGL stimulated food intake of NC and MFSD, especially during the light period. By contrast, NPGL decreased body mass gain under NC and increased total white adipose tissue mass in HSD- and MFSD-fed rats. These data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type. Among them, sucrose in diets seems to contribute to fat accumulation elicited by NPGL.

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Establishment of partner preference in male rats: Effect of prenatal letrozole and sexual experience

Hormones and Behavior ◽

10.1016/j.yhbeh.2019.02.009 ◽

2019 ◽

Vol 109 ◽

pp. 56-63 ◽

Cited By ~ 1

Author(s):

Sandra Olvera-Hernández ◽

Alejandra Hernández ◽

Rebeca Reyes ◽

Alonso Fernández-Guasti

Keyword(s):

Sexual Experience ◽

Male Rats ◽

Partner Preference

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Influence of size and partner preference on the female function of the earthworm Eisenia andrei (Oligochaeta, Lumbricidae)

European Journal of Soil Biology ◽

10.1016/j.ejsobi.2006.07.010 ◽

2006 ◽

Vol 42 ◽

pp. S331-S333 ◽

Cited By ~ 10

Author(s):

Andrea Tato ◽

Alberto Velando ◽

Jorge Domínguez

Keyword(s):

Eisenia Andrei ◽

Partner Preference ◽

Female Function

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Circulating Secretin Activates Supraoptic Nucleus Oxytocin and Vasopressin Neurons via Noradrenergic Pathways in the Rat

Endocrinology ◽

10.1210/en.2009-1440 ◽

2010 ◽

Vol 151 (6) ◽

pp. 2681-2688 ◽

Cited By ~ 28

Author(s):

Sathya Velmurugan ◽

Paula J. Brunton ◽

Gareth Leng ◽

John A. Russell

Keyword(s):

Amino Acid ◽

Firing Rate ◽

Noradrenaline Release ◽

Supraoptic Nucleus ◽

Female Rats ◽

Adrenoceptor Antagonist ◽

Intracerebroventricular Infusion ◽

Neuroendocrine Neurons ◽

Vasopressin Neurons

Secretin is a 27-amino acid brain-gut peptide from duodenal S-cells. We tested the effects of systemic administration of secretin to simulate its postprandial release on neuroendocrine neurons of the supraoptic nucleus (SON) in urethane-anesthetized female rats. Secretin dose-dependently increased the firing rate of oxytocin neurons, more potently than cholecystokinin, and dose-dependently increased plasma oxytocin concentration. The effect of secretin on SON vasopressin neurons was also predominantly excitatory, in contrast to the inhibitory actions of cholecystokinin. To explore the involvement of noradrenergic inputs in secretin-induced excitation, benoxathian, an α1-adrenoceptor antagonist, was infused intracerebroventricularly. Benoxathian intracerebroventricular infusion blocked the excitation by secretin of both oxytocin and vasopressin neurons. To test the role of local noradrenaline release in the SON, benoxathian was microdialyzed onto the SON. The basal firing rate of oxytocin neurons was slightly reduced and the secretin-induced excitation was attenuated during benoxathian microdialysis. Hence, noradrenergic pathways mediate the excitation by systemic secretin of oxytocin neurons via α1-adrenoceptors in the SON. As both systemic secretin and oxytocin are involved in regulating gastrointestinal functions and natriuresis, systemically released secretin might act partly through oxytocin.

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