Experimental basis for neurotic behavior: Origin and development of artificially produced disturbances of behavior in dogs.

1944 ◽  
Author(s):  
W. Horsley Gantt
Keyword(s):  
Experimental Basis

Experimental basis for the topical application of angiotensin-convertingenzyme inhibitor as an anti-ischemic drug in experimental eye ischemia

2020 ◽  
pp. 75-76
Author(s):  
O.A. Lisovskaya ◽  
◽  
T.A. Pavlenko ◽  
O.V. Beznos ◽  
N.B. Chesnokova ◽  
...  
Keyword(s):  
Topical Application ◽  
Experimental Basis

Актуальность. Перспективным направлением в терапии ишемических процессов является фармакологическая регуляция ренин-ангиотензиновая система (РАС), а также изучение возможности восстановления нарушенной гемодинамики глаза путем местного применения ингибиторов ангиотензин-превращающего фермента (АПФ). Цель. Изучить возможность восстановления нарушенной гемодинамики глаза путем местного применения ингибиторов АПФ. Материал и методы. В работе было задействовано 15 кроликов. Для создания экспериментальной модели ишемии глаза кроликам проводили субконъюнктивальную инъекцию в каждый глаз по 0,2 мл сосудосуживающего препарата Мезатон. Для количественной оценки степени ишемии применяли метод офтальмоплетизмографии (ОПГ).Проводили однократную инстилляцию раствора эналаприлата (1,25мг/мл) в OD -опытный глаз, в контрольный глаз (OS) - фосфатный буфер. ОПГ на всех этапах эксперимента проводили одновременно на обоих глазах животных до субконъюктивальной инъекции и каждые 60 мин после, в течение 180 мин. Осуществляли взятие внутриглазной жидкости (ВГЖ) из передней камеры обоих глаз. В образцах ВГЖ определяли уровень активности АПФ по начальным скоростям гидролиза субстрата Cbz-Phe-His-Leu. Результаты. В результате уровень минутный объем кровотока (МОК) опытного глаза под влиянием инстилляций ингибитора АПФ в интервале от 60 до 180 мин превышал значения МОК в контрольном глазу без лечения на 15-42%. Также после инстилляция эналаприлата достоверно снижаласьактивность АПФ (р<0,01) на 50% и 75% относительно контрольных значений. Выводы. Увеличение глазного кровотока на фоне ишемии и снижение активности АПФ в ВГЖ свидетельствует о противоишемическом действии ингибитора АПФ, что указывает на способность ингибитора преодолевать тканевые барьеры роговицы и оказывать влияние на локальную ренин-ангиотензиновую систему глаза.

CHARACTERISATION OF THE NITRIFICATION PROCESS FOR DESIGN PURPOSES

1994 ◽  
Vol 30 (4) ◽  
pp. 47-56 ◽  
Author(s):  
O. Sinkjær ◽  
L. Yndgaard ◽  
P. Harremoës ◽  
J. L. Hansen
Keyword(s):  
Kinetic Theory ◽  
Nitrification Rate ◽  
Experimental Basis ◽  
Batch Tests ◽  
Mode Of Operation ◽  
Nitrification Process ◽  
Aerobic Reactor ◽  
The City ◽  
Specific Evaluation ◽  
Aerobic Sludge

Pilot plant experiments have been performed over a period of four years in order to establish an experimental basis for the upgrading of the treatment plants of the city of Copenhagen to nitrogen removal. The design chosen is based on the alternating mode of operation. Nitrification rates have been determined in batch tests on activated sludge extracted from the pilot plants and through the measuring of transient concentrations during the alternating mode of operation in the aerobic reactor. The data have been nonnalised to standard conditions by correcting them according to the kinetic theory. By monitoring the normalised nitrification rate it could be established that the nitrification process was occasionally inhibited. The aerobic sludge age required to maintain nitrification has been estimated. A specific evaluation has been made of the sensitivity of the required sludge age to the oxygen concentration and temperature.

Modelling of activated sludge for textile wastewaters

1998 ◽  
Vol 38 (4-5) ◽  
pp. 9-17 ◽  
Author(s):  
F. Germirli Babuna ◽  
D. Orhon ◽  
E. Ubay Çokgör ◽  
G. Insel ◽  
B. Yaprakli
Keyword(s):  
Activated Sludge ◽  
Comprehensive Evaluation ◽  
Component Model ◽  
Activated Sludge Process ◽  
Experimental Basis ◽  
Model Simulations ◽  
Effluent Quality ◽  
Model Based ◽  
Major Process ◽  
Textile Wastewaters

A comprehensive evaluation of four different textile wastewaters was carried out to set the experimental basis for the modelling of activated sludge process. Experiments involved beside conventional characterization, detailed COD fractionation and assessment of major kinetic and stoichiometric coefficients by means of respirometric measurements. A multi-component model based on the endogenous decay concept was used for the kinetic interpretation and design of activated sludge. The fate and variation of major process components affecting effluent quality with the sludge age were evaluated by means of model simulations.

Perspectives

2017 ◽  
Author(s):  
Armin Schnider
Keyword(s):  
Experimental Investigation ◽  
Experimental Evidence ◽  
Empirical Evidence ◽  
False Memories ◽  
Experimental Basis ◽  
The Relationship ◽  
Scientific Standards

This chapter summarizes current interpretations of all forms of confabulations discussed in the book and reviews the relationship between the four forms of memory-related confabulations. Experimental investigation has confirmed the dissociation between various types of false memories and considerably advanced the understanding of the mechanisms of some forms of confabulation, in particular behaviourally spontaneous confabulation and false statements in anosognosia. Overall, experimental evidence is scarce; many models have no controlled experimental basis or extend their proposed range of application well beyond the empirical evidence. The chapter concludes with a call for heightened respect of basic scientific standards in the research on confabulation.

The Extraction of Main Chemical Compositions in Rumex Root

2011 ◽  
Vol 382 ◽  
pp. 372-374
Author(s):  
Yong Jiang ◽  
Zhi Bin Jiang ◽  
Guo Jie Shao ◽  
Dong Cheng Guo ◽  
Yu Tian ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Chemical Properties ◽  
Ethanol Extract ◽  
Chemical Compositions ◽  
Physical And Chemical Properties ◽  
Experimental Basis ◽  
Development And Utilization ◽  
Physical And Chemical ◽  
Root Methods ◽  
And Chemical Properties

Purpose: The purpose of this study was to study the compositions of the polygonaceae medicinal plants called rumex root. Methods: Solvent method and chromatography was used to purificate the chemical compositions of Rumex, and the molecular structure of the compound was identified by physical and chemical properties and spectral data. Results: Two compounds were obtained from the ethanol extract of rumex root, which were identified as Chrysophanol and Physcione. Conclusions: Experimental basis was provided for the further study of the active ingredients of rumex root and the development and utilization of medical resources.

The melanocortin system

2003 ◽  
Vol 284 (3) ◽  
pp. E468-E474 ◽  
Author(s):  
Ira Gantz ◽  
Tung M. Fong
Keyword(s):  
Sexual Function ◽  
Energy Homeostasis ◽  
Melanocortin Receptors ◽  
Experimental Basis ◽  
Melanocortin System ◽  
Genetic Studies ◽  
Melanocortin Peptides ◽  
Selective Agonists ◽  
Made In

The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four areas. In particular, recent pharmacological and genetic studies have affirmed the role of melanocortins in pigmentation, inflammation, energy homeostasis, and sexual function. Development of selective agonists and antagonists is expected to further facilitate the investigation of these complex physiological functions and provide an experimental basis for new pharmacotherapies.

Effect of Purified Collagen on Lipograft Survival: Experimental Basis for Periurethral Lipoinjections

2003 ◽  
Vol 17 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Paulo César Rodrigues Palma ◽  
Benedicto Vidal ◽  
Cássio Luís Zanettini Riccetto ◽  
Viviane Herrmann ◽  
Míriam Dambros ◽  
...  
Keyword(s):  
Experimental Basis

Manufacture of the Glass Nanopore Based on Laser Heating and Experimental Research

2016 ◽  
Vol 851 ◽  
pp. 244-248
Author(s):  
Ya Fei Zhang ◽  
Zhi Yuan Yao ◽  
Bi Cheng Wu
Keyword(s):  
Laser Heating ◽  
Chemical Method ◽  
Physical Method ◽  
Experimental Basis ◽  
Generation System ◽  
Glass Capillary ◽  
Linear Ultrasonic Motor ◽  
Capillary Tension ◽  
Through Hole

The glass nanopore produced by the physical method has better physical characteristics, higher strength, stronger stability, longer life and other significant features compared with the chemical method. The purpose of this paper is to study DNA sequencing (973 project) to provide experimental basis for preparation of glass capillary 5nm 3D nanochannel In this paper, we design a set of glass capillary tension system which is controlled by laser heating and linear ultrasonic motor and produced successfully the device for the preparation of nanopore below 50 nm. In addition, the use of micro droplet generation system has carried out preliminary characterization of nanopore drawn devices. Seen from the characterization, the nanopore device fabricated can indeed produce a through-hole.

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