Does changing social influence engender changes in alcohol intake? A meta-analysis.

Introduction: Although considerable research describes the cardiovascular effects of habitual moderate and heavy alcohol consumption, the acute risks following alcohol intake have not been well characterized. Based on its physiological effects, alcohol may have markedly different effects on acute and long-term risk. We assessed the hypothesis that moderate alcohol consumption is associated with an immediately higher risk of cardiovascular events that becomes protective after 24 hours, whereas heavy alcohol drinking is associated with higher cardiovascular risk both immediately and in the following days. Methods: We searched CINAHL, Embase, PubMed and PsycINFO from inception to March 12 2015, supplemented with manual screening for observational studies assessing the association between alcohol intake and cardiovascular events in the following hours and days. We calculated pooled relative risks (RRs) and 95% confidence intervals (CIs) for the association between alcohol intake and myocardial infarction (MI), ischemic stroke (IS) and hemorrhagic stroke (HS) using DerSimonian and Laird random-effects models to model any alcohol intake or dose-response relationships of alcohol intake and cardiovascular events. Results: Among 1056 citations and 37 full-text articles reviewed, 23 studies (29457 participants) were included. Moderate alcohol consumption was associated with an acutely higher cardiovascular risk that was attenuated after 24 hours and even protective for MI and HS (≈2-4 drinks: RR=30% lower risk), and protective against IS within one week (≈6 drinks: RR=19% lower risk). In contrast, heavy alcohol drinking was associated with higher cardiovascular risk in the following day (≈6-9 drinks: RR=1.3-2.3) and week (≈19-30 drinks: RR=2.25-6.2). Conclusions: In conclusion, there appears to be a consistent finding of an acutely higher cardiovascular risk following any alcohol consumption but by 24 hours, only heavy alcohol intake conferred continued risk.

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Alcohol intake and risk of nonmelanoma skin cancer: a systematic review and dose–response meta‐analysis

British Journal of Dermatology ◽

10.1111/bjd.15647 ◽

2017 ◽

Vol 177 (3) ◽

pp. 696-707 ◽

Cited By ~ 14

Author(s):

H. Yen ◽

A. Dhana ◽

J.‐P. Okhovat ◽

A. Qureshi ◽

N. Keum ◽

...

Keyword(s):

Systematic Review ◽

Skin Cancer ◽

Dose Response ◽

Alcohol Intake ◽

Meta Analysis ◽

Nonmelanoma Skin Cancer

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Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

10.1101/2020.08.17.254185 ◽

2020 ◽

Author(s):

Franc Casanova Ferrer ◽

María Pascual ◽

Marta R. Hidalgo ◽

Pablo Malmierca-Merlo ◽

Consuelo Guerri ◽

...

Keyword(s):

Alcohol Dependence ◽

Intracellular Transport ◽

Alcohol Intake ◽

Meta Analysis ◽

Subsequent Development ◽

Social Consequences ◽

Psychological Consequences ◽

Biological Mechanisms ◽

Physiological Mechanisms ◽

Transcriptomic Studies

AbstractThe abuse of alcohol, one of the most popular psychoactive substances, can cause several pathological and psychological consequences, including alcohol use disorder (AUD). An impaired ability to stop or control alcohol intake despite adverse health or social consequences characterize AUD. While AUDs predominantly occur in men, growing evidence suggests the existence of distinct cognitive and biological consequences of alcohol dependence in women. The molecular and physiological mechanisms participating in these differential effects remain unknown. Transcriptomic technology permits the detection of the biological mechanisms responsible for such sex-based differences, which supports the subsequent development of novel personalized therapeutics to treat AUD. We conducted a systematic review and meta-analysis of transcriptomics studies regarding alcohol dependence in humans with representation from both sexes. For each study, we processed and analyzed transcriptomic data to obtain a functional profile of pathways and biological functions and then integrated the resulting data by meta-analysis to characterize any sex-based transcriptomic differences associated with AUD. Global results of the transcriptomic analysis revealed the association of decreased tissue regeneration, embryo malformations, altered intracellular transport, and increased rate of RNA and protein replacement with female AUD patients. Meanwhile, our analysis indicated that increased inflammatory response and blood pressure and a reduction in DNA repair capabilities associated with male AUD patients. In summary, our functional meta-analysis of transcriptomic studies provides evidence for differential biological mechanisms that AUD patients of differing sex.Abstract Figure

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Alcohol Intake and the Risk of Age-Related Cataracts: A Meta-Analysis of Prospective Cohort Studies

PLoS ONE ◽

10.1371/journal.pone.0107820 ◽

2014 ◽

Vol 9 (9) ◽

pp. e107820 ◽

Cited By ~ 8

Author(s):

Wei Wang ◽

Xiulan Zhang

Keyword(s):

Cohort Studies ◽

Prospective Cohort ◽

Alcohol Intake ◽

Meta Analysis ◽

Prospective Cohort Studies ◽

Age Related

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Alcohol Consumption by Beverage Type and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Alcohol and Alcoholism ◽

10.1093/alcalc/agaa012 ◽

2020 ◽

Vol 55 (3) ◽

pp. 246-253 ◽

Cited By ~ 1

Author(s):

Qiuyu Sun ◽

Weihong Xie ◽

Yanli Wang ◽

Feifei Chong ◽

Mengmeng Song ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cohort Studies ◽

Postmenopausal Women ◽

Dose Response ◽

Alcohol Intake ◽

Meta Analysis ◽

Response Analysis ◽

Total Alcohol

Abstract Aims Alcohol intake has been shown to increase the risk of breast cancer. However, the dose-response analysis of different alcoholic beverages (spirits, wine and beer) is not clear. Our meta-analysis aims to provide a dose-response estimation between different alcohols and breast cancer risk. Methods Search of PubMed and Web of Science and manual searches were conducted up to 1 December 2018, and summary relative risks (RRs) and attributable risk percentage (ARP) for alcohol intake on the development of breast cancer were calculated. Dose-response meta-analysis modeled relationships between drinking type and breast cancer risk. Sources of heterogeneity were explored, and sensitivity analyses were conducted to test the robustness of findings. Results In total, 22 cohort studies and 45,350 breast cancer cases were included. Current drinkers for ER+ had an increased risk compared with never drinkers. In dose-response analysis, there was a statistically significant linear trend with breast cancer risk increasing gradually by total alcohol and wine dose: when adding 10 g per day, the risk increased by 10.5% (RR = 1.10, 95%CI = 1.08–1.13) in total alcohol and 8.9% (RR = 1.08, 95%CI = 1.04–1.14) in wine. For postmenopausal women, the risk increases by 11.1% (RR = 1.11, 95%CI = 1.09–1.13) with every 10 g of total alcohol increase. Furthermore, the breast cancer alcohol-attributed percentage is higher in Europe than in North America and Asia. Conclusions The effect of drinking on the incidence of breast cancer is mainly manifested in ER+ breast cancer. Quantitative analysis showed total drinking had a significant risk for breast cancer, especially for postmenopausal women. However, for different alcohols, just wine intake has the similar results.

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