Short-term cognitive functioning after electroconvulsive therapy

2008 ◽  
Author(s):  
L. Rami ◽  
J. Goti ◽  
J. Ferrer ◽  
T. Marcos ◽  
M. Salamero ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Electroconvulsive Therapy ◽  
Short Term

Inflammatory Markers May Inform the Effects of Electroconvulsive Therapy on Cognition in Patients with Depression

2021 ◽  
pp. 1-9
Author(s):  
Jan-Baptist Belge ◽  
Linda Van Diermen ◽  
Bernard Sabbe ◽  
Manuel Morrens ◽  
Violette Coppens ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Cognitive Functioning ◽  
Electroconvulsive Therapy ◽  
Inflammatory Markers ◽  
Verbal Learning ◽  
Potential Biomarker ◽  
Tnf Α ◽  
Autobiographic Memory ◽  
Learning Test ◽  
Verbal Episodic Memory

<b><i>Introduction:</i></b> The neurobiological mechanisms underlying the acute cognitive effects of electroconvulsive therapy (ECT) remain poorly understood. Prior research has shown that proinflammatory cytokines such as IL-6, TNF-α, IL1-β, and IL-10 may interfere with cognitive functioning. Interestingly, immunomodulation is one of the proposed modes of action of ECT. This study investigates whether changes of peripheral levels of IL-6, TNF-α, IL1-β, and IL-10 are related to changes in cognitive functioning following ECT. <b><i>Methods:</i></b> In the week before and 1 week after an acute course of ECT, 62 patients suffering from depression underwent a neuropsychological evaluation to assess their processing speed using the Symbol Digit Substitution Test (SDST), verbal episodic memory using the Hopkins Verbal Learning Test-Revised (HVLT-R), and their retrospective autobiographic memory using the Autobiographical Memory Interview (AMI) with the peripheral inflammatory markers being measured at the same 2 time points. <b><i>Results:</i></b> Patients improved drastically following ECT, while their main performance on both the HVLT-R and AMI declined and their SDST scores remained stable. The levels of IL-6 and IL1-β had both decreased, where the decrease in IL-6 was related to the decrease in HVLT-R scores. Higher baseline IL-10 levels were associated with a more limited decrease of the HVLT-R scores. <b><i>Conclusion:</i></b> Our findings tentatively suggest that the effects of ECT on verbal episodic memory may be related to the treatment’s immunomodulatory properties, most notably due to decreased IL-6 levels. Moreover, baseline IL-10 appears to be a potential biomarker to predict the effects of ECT on verbal episodic memory. Whilst compelling, the results of this study should be interpreted with caution as, due to its exploratory nature, no correction for multiple comparisons was made. Further, a replication in larger cohorts is warranted.

Safety and efficacy of electroconvulsive therapy for depression following cerebrovascular accident

2012 ◽  
Vol 24 (4) ◽  
pp. 226-229 ◽  
Author(s):  
Magdalena Romanowicz ◽  
Bruce Sutor ◽  
Christopher Sola
Keyword(s):  
Electroconvulsive Therapy ◽  
Cerebrovascular Accident ◽  
Chart Review ◽  
Short Term Memory ◽  
Retrospective Chart Review ◽  
Neurological Deficits ◽  
Response To Treatment ◽  
Short Term ◽  
Memory Problems ◽  
Depressive Syndromes

Introduction: Depressive syndromes are common following cerebrovascular accident (CVA) and many patients do not respond to pharmacotherapy. Electroconvulsive therapy (ECT) is a safe and effective treatment for mood disorders arising with many comorbid medical conditions. In this paper, we describe the successful treatment of post-CVA depression with ECT.Methods: Retrospective chart review of 24 patients hospitalised for depression on an in-patient Medical Psychiatry unit between 2000 and 2010. Medical, neurologic and psychiatric histories, physical examination findings, results of laboratory, imaging and neurophysiologic investigations and treatment response with medications and ECT were recorded.Results: Twenty patients (83%) showed a positive response to treatment with ECT. None had worsening of depression after the ECT or experienced exacerbation of post-stroke neurological deficits. Three patients suffered from minor complications of ECT (prolonged confusion or short-term memory problems).Conclusions: This review supports the use of ECT after a stroke with appropriate clinical observation. The treatment was well tolerated and the majority obtained clinical benefit.

scholarly journals Clinical Predictors of Short-Term Outcome in Electroconvulsive Therapy

1999 ◽  
Vol 44 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Raymond W Lam ◽  
Simon Bartley ◽  
Lakshmi N Yatham ◽  
Edwin M Tam ◽  
Athanasios P Zis
Keyword(s):  
Electroconvulsive Therapy ◽  
Clinical Predictors ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome

Decreased Cognitive Functioning After Electroconvulsive Therapy Is Related to Increased Hippocampal Volume

2018 ◽  
Vol 34 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Iris van Oostrom ◽  
Philip van Eijndhoven ◽  
Elke Butterbrod ◽  
Maria H. van Beek ◽  
Joost Janzing ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Electroconvulsive Therapy ◽  
Hippocampal Volume

scholarly journals Electroconvulsive therapy hasn’t negative effects on short-term memory function, as assessed using a bedside hand-held device

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Helge H.O. Müller ◽  
Mareen Reike ◽  
Simon Grosse-Holz ◽  
Mareike Röther ◽  
Caroline Lücke ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Electroconvulsive Therapy ◽  
Short Term Memory ◽  
Memory Function ◽  
Memory Deficits ◽  
Treatment Resistant ◽  
Negative Effects ◽  
Short Term ◽  
Term Memory ◽  
Digital Measurements

Electroconvulsive therapy (ECT) is effective in the treatment of treatment-resistant major depression. The fear of cognitive impairment after ECT often deters patients from choosing this treatment option. There is little reliable information regarding the effects of ECT on overall cognitive performance, while short-term memory deficits are well known but not easy to measure within clinical routines. In this pilot study, we examined ECT recipients’ pre- and posttreatment performances on a digital ascending number tapping test. We found that cognitive performance measures exhibited good reproducibility in individual patients and that ECT did not significantly alter cognitive performance up to 2 hours after this therapy was applied. Our results can help patients and physicians make decisions regarding the administration of ECT. Digital measurements are recommended, especially when screening for the most common side effects on cognitive performance and short-term memory.

Effect of Antidepressant Medication Resistance on Short-term Response to Electroconvulsive Therapy

2004 ◽  
Vol 24 (4) ◽  
pp. 400-403 ◽  
Author(s):  
Walter W. van den Broek ◽  
Ariejan de Lely ◽  
Paul G.H. Mulder ◽  
Tom K. Birkenh??ger ◽  
Jan A. Bruijn
Keyword(s):  
Electroconvulsive Therapy ◽  
Antidepressant Medication ◽  
Short Term ◽  
Term Response
Sign in / Sign up

Export Citation Format

Share Document