Results of hearing tests in young children are influenced by testing technique, age group, and middle-ear fluid

2003 ◽  
Keyword(s):  
Young Children ◽  
Middle Ear ◽  
Age Group ◽  
Hearing Tests ◽  
Testing Technique ◽  
Middle Ear Fluid

Substantial reduction of antibiotic-non-susceptible pneumococcal otitis media following PCV7/PCV13 sequential introduction

2020 ◽  
Vol 75 (10) ◽  
pp. 3038-3045
Author(s):  
Shalom Ben-Shimol ◽  
Noga Givon-Lavi ◽  
David Greenberg ◽  
Bart Adriaan van der Beek ◽  
Eugene Leibovitz ◽  
...  
Keyword(s):  
Young Children ◽  
Otitis Media ◽  
Active Surveillance ◽  
Middle Ear ◽  
Substantial Reduction ◽  
Population Based ◽  
Vaccine Serotypes ◽  
Middle Ear Fluid ◽  
Fluid Culture

Abstract Background In the pre-pneumococcal conjugated vaccines (PCVs) era, serotypes included in the 7/13-valent PCVs (PCV7/PCV13) caused most pneumococcal otitis media (OM) and antibiotic-non-susceptible pneumococcal OM (ANSP-OM) episodes. In southern Israel, sequential PCV7/PCV13 introduction resulted in >90% reduction of vaccine-serotype OM. Objectives We assessed the dynamics of ANSP-OM necessitating middle ear fluid culture following PCV7/PCV13 sequential introduction in young children. Methods This was a prospective, population-based, active surveillance. All episodes in children <3 years old, during 2004–16, were included. Two subperiods were defined: (i) pre-PCV: 2004–08; and (ii) PCV13: 2014–16. ANSP was defined for the following antibiotics: penicillin (MIC ≥0.1 mg/L and ≥1.0 mg/L), macrolide, tetracycline, clindamycin, ceftriaxone, trimethoprim/sulfamethoxazole and chloramphenicol. MDR was defined as ANSP for ≥3 classes. Results Overall, 2270 pneumococcal OM episodes were identified. Annual overall pneumococcal, PCV13 and non-PCV13 serotype OM incidence declined by 86%, 97% and 33%, respectively, comparing pre-PCV with the PCV13 period. During 2004–08, 95% of ANSP was observed in vaccine serotypes. Incidence of penicillin (MIC ≥0.1 mg/L and ≥1.0 mg/L), macrolide, tetracycline, clindamycin, ceftriaxone and multidrug ANSP-OM declined by >90% in the PCV13 period. Rates of trimethoprim/sulfamethoxazole and chloramphenicol ANSP-OM declined by 85% and 79%, respectively. The proportions of ANSP of all pneumococcal isolates declined by ∼70% for penicillin, ceftriaxone and erythromycin; 53% for tetracycline; and 55% for MDR, versus no significant reductions observed for chloramphenicol, trimethoprim/sulfamethoxazole and clindamycin. Conclusions PCV7/PCV13 sequential introduction resulted in rapid and substantial ANSP-OM reduction, in parallel with the near disappearance of PCV13-serotype OM and no increase in replacement disease.

scholarly journals Antibody in Middle Ear Fluid of Children Originates Predominantly from Sera and Nasopharyngeal Secretions

2012 ◽  
Vol 19 (10) ◽  
pp. 1593-1596 ◽  
Author(s):  
Ravinder Kaur ◽  
Thomas Kim ◽  
Janet R. Casey ◽  
Michael E. Pichichero
Keyword(s):  
Middle Ear ◽  
Acute Otitis Media ◽  
Secretory Iga ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Two Dimensional Gel Electrophoresis ◽  
Middle Ear Fluid ◽  
Iga Antibodies ◽  
Iga Antibody ◽  
Entire Array

ABSTRACTThe human middle ear is devoid of any immunocompetent cells in normal mucosa. We sought to determine the source of antibody present in the middle ear of children. Total IgG, IgA, and secretory IgA antibodies were determined by enzyme-linked immunosorbent assay from the nasopharyngeal, middle ear, and serum samples of children with acute otitis media. The two-dimensional gel electrophoresis pattern of the entire array of IgA antibodies in the nasal wash (NW) and middle ear fluid (MEF) was compared from the MEF and NW samples using isoelectric focusing and Western blotting. The total IgG and IgA antibodies in the MEF and NW samples of 137 children were compared. The ratio of IgG to IgA in the MEF was significantly different (P< 0.008) compared to NW because IgA levels were higher and IgG levels lower in NW. The IgG/IgA ratio of MEF resembled serum consistent with transudation to the MEF. Small amounts of secretory IgA were detected in MEF but the electrophoresis patterns of the entire array of IgA antibodies in the MEF and NW were virtually identical in each child evaluated; thus, IgA in MEF derived predominantly from serum and the nasopharynx by reflux via the Eustachian tube. The IgG/IgA antibody levels in the MEF and the same composition of IgA antibody in the MEF and NW identifies the predominant source of antibody in the MEF as a transudate of serum combined with nasal secretions refluxed from the nasopharynx in children.

Air Conduction Thresholds and Secretory Otitis Media: A Conventional and Extra-High Frequency Audiometric Comparison

1989 ◽  
Vol 98 (10) ◽  
pp. 767-771 ◽  
Author(s):  
Iain W. S. Mair ◽  
Oddbjørn Fjermedal ◽  
Einar Laukli
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
High Frequency ◽  
Pure Tone ◽  
Low Frequency ◽  
Secretory Otitis Media ◽  
Middle Ear Fluid ◽  
Ventilation Tubes ◽  
Air Conduction

A comparison has been made of air conduction threshold changes up to 1 year after myringotomy, aspiration of middle ear fluid, and insertion of ventilation tubes in ten patients with bilateral and 12 with unilateral secretory otitis media (SOM). Pure tone air conduction thresholds have been analyzed in three frequency groups: Low frequency (LF; 0.25, 0.5, and 1 kHz), high frequency (HF; 2,4, and 8 kHz), and extra-high frequency (EHF; 10, 12, 14, and 16 kHz). In the LF and HF ranges, significant improvement came during the first 24 hours after intubation, while in the EHF range, threshold lowering occurred gradually over the following 2 months. Possible explanations for these findings are discussed.

scholarly journals Acute Mastoiditis in the Pneumococcal Conjugate Vaccine Era

2014 ◽  
Vol 21 (8) ◽  
pp. 1189-1191 ◽  
Author(s):  
Sharon Ovnat Tamir ◽  
Yehudah Roth ◽  
Ilan Dalal ◽  
Abraham Goldfarb ◽  
Tal Marom
Keyword(s):  
Streptococcus Pneumoniae ◽  
Middle Ear ◽  
Pneumococcal Conjugate Vaccine ◽  
Inverse Relationship ◽  
Acute Otitis Media ◽  
Acute Mastoiditis ◽  
Conjugate Vaccines ◽  
Content Type ◽  
Bacterial Cultures ◽  
Middle Ear Fluid

ABSTRACTFollowing the introduction of the 7- and 13-valent pneumococcal conjugate vaccines, we observed an inverse relationship between the increasing rate of immunized children and the proportion of middle ear fluid cultures collected during acute mastoiditis episodes that tested positive forStreptococcus pneumoniaeamong a subset of children 0 to 6 years old who had initially presented with severe acute otitis media and had bacterial cultures collected during tympanocentesis or from spontaneous otorrhea.

Total water intake and its contributors in infants and young children

2021 ◽  
pp. 1-32
Author(s):  
Jean-Pierre Chouraqui ◽  
Simon N. Thornton ◽  
Louise Seconda ◽  
Stavros A. Kavouras
Keyword(s):  
Young Children ◽  
Water Intake ◽  
Water Consumption ◽  
Consumption Pattern ◽  
Plain Water ◽  
Age Group ◽  
Total Water ◽  
Beverage Consumption ◽  
Infants And Young Children ◽  
Total Water Intake

Abstract Hydration is a particular concern for infants and young children due to their greater risk of dehydration. However, studies on their water intakes are scarce. The current survey aimed to analyze total water intake (TWI) in non-breastfed children aged 0.5-35 months compared to the adequate intake (AI) for the same age group set by the EFSA and to examine the different contributors to TWI as well as beverage consumption patterns. Nationally representative data from the Nutri-Bébé cross-sectional survey were used to assess food, beverage, and plain water consumption by age group over three non-consecutive days. With age, median TWI in 1,035 children increased from 732 to 1010 mL/d, without differences between sex, but with a great inter-individual variation, and the percentage of children who did not meet the AI increased from 10% to 88%. Median weight-related TWI decreased from 136.6 to 69.0 mL/kg/d. Among infants, 90% had a ratio of water/energy below the AI, similarly for about 75% of toddlers. Milk and milk products were the main contributors to TWI, while the part of plain water increased gradually to be 25% in the older toddlers, half of which was tap water. The beverage consumption pattern varied in types and timing, with little consumption of juices and sweetened beverages. Vegetables and fruits accounted for 20% of TWI after the age of 6 months. These initial results, showing strong discrepancies between actual and recommended water intakes in young children, should help identify ways to increase children’s water consumption.

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