Adjustment to noise stress

Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved. This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200 mg/kg body weight for 28 days. Rats in the stress group were subjected to loud noise, 100 dB(A), 4 hours daily for 14 days. All rats were subjected to novel object recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system.

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Five Different Noise Intensities Robustly Affects Corticosterone, Gastrin and Endothelin-1 Responses and Initiated Gastric Tissue Damage in Wistar Rats

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i54a33719 ◽

2021 ◽

pp. 54-69

Author(s):

Ravinder Kumar Mehra ◽

Mahesh Prashad ◽

Dinesh Kumar Sharma ◽

Prevesh Kumar

Keyword(s):

Stress Response ◽

Tissue Damage ◽

Biological Systems ◽

Gastric Damage ◽

Control Group ◽

Stress Exposure ◽

Sham Control ◽

Endothelin 1 ◽

Noise Stress ◽

Sham Control Group

Likewise other stress response noise stress is also affects the homeostasis of the biological systems and produce stress response in the form of Corticosterone to prevent the damage but if the exposure is longer with higher magnitude it may disrupt the robust ability of the homeostasis and could produce the damage to the biological systems. The goal of our study was to see how five different noise intensities affected stomach tissue damage. 42 healthy rats were divided into five different stress exposure group, normal control (NC) and sham control (SC) groups. Noise stress exposure was delivered for 1 hour per day continued for 30 days in all five noise exposed groups by specially designed noise chamber whereas sham control group of animals kept in noise chamber for 1 hour per day continued for 30 days without noise stress exposure and control group of animals neither exposed to noise stress of any intensities and nor kept in noise chamber without noise but remain in the same experimental room in their homecage for 30 days respectively. Results of the study showed that animals exposed to 60 and 80 dB noise give habituated and not significant Corticosterone, Gastrin and Endothelin-1 responses compared to NC and SC groups while animals exposed to 100, 120 and 140 dB had significantly higher Corticosterone, Gastrin and Endothelin-1 response and also chronic gastric damage was observed compared to later two noise exposed groups respectively. Study concluded that not only higher but also lower noise intensities also initiated the gastric damage even after the adaptation.

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Alteration in memory and electroencephalogram waves with sub-acute noise stress in albino rats and safeguarded by Scoparia dulcis

Pharmacognosy Magazine ◽

10.4103/0973-1296.176119 ◽

2016 ◽

Vol 12 (45) ◽

pp. 7 ◽

Cited By ~ 3

Author(s):

Sheeladevi Rathinasamy ◽

Sundareswaran Loganathan

Keyword(s):

Albino Rats ◽

Noise Stress ◽

Scoparia Dulcis

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Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v12i3.1871 ◽

2021 ◽

Vol 12 (2) ◽

pp. 226-231

Author(s):

Archana Arjunan ◽

Dhiraj Kumar Sah ◽

Ravindran Rajan

Keyword(s):

Neuroprotective Effect ◽

Hippocampal Volume ◽

Glycyrrhiza Glabra ◽

Albino Rats ◽

Behavioral Alterations ◽

Obsessive Compulsive ◽

Noise Stress ◽

Wistar Albino Rats ◽

Fear And Anxiety ◽

Hippocampal Morphology

Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats. Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days), Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p<0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.

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