Nocturnal Enuresis, Sleep Disordered Breathing, and Tonsilloadenoidectomy in Pediatric Sickle Cell Disease

2011 ◽  
Author(s):  
Sunnye Mayes ◽  
David Fedele ◽  
Angelica R. Eddington ◽  
Sarah E. Stearns ◽  
T. David Elkin ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Nocturnal Enuresis ◽  
Sleep Disordered Breathing ◽  
Cell Disease ◽  
Pediatric Sickle Cell Disease ◽  
Disordered Breathing

scholarly journals Adenotonsillar Hypertrophy in Pre-School Children with Sickle Cell Disease and Diagnostic Accuracy of the Sleep Disturbance Scale for Children

2017 ◽  
Vol 22 (01) ◽  
pp. 055-059
Author(s):  
Carlos Góis ◽  
Jeferson D'Ávila ◽  
Rosana Cipolotti ◽  
Amanda Lira ◽  
Ana Silva
Keyword(s):  
Sickle Cell Disease ◽  
Sleep Disturbance ◽  
Sickle Cell ◽  
School Children ◽  
Sleep Disordered Breathing ◽  
Statistical Significance ◽  
Control Group ◽  
Cell Disease ◽  
Adenotonsillar Hypertrophy ◽  
Disordered Breathing

Introduction Adenotonsillar hypertrophy is more common in children with sickle cell disease, and can lead to sleep-disordered breathing. Objectives To determine the frequency of adenotonsillar hypertrophy in pre-school children with sickle cell disease and assess the diagnostic accuracy of the sleep-disordered breathing subscale in the Sleep Disturbance Scale for Children. Method Observational study with a group of 48 children with sickle cell disease and a control group of 35 children without the disease. The children underwent oropharingoscopy and video nasal endoscopy. The parents and/or guardians answered the questions of the subscale. Results Adenotonsillar hypertrophy was observed in 25% of the children in the study group, and in 20% of the children in the control group, with no statistical difference between the groups. The subscale score ranged from 3 to 11 in both groups. There was a statistical significance in the study group. The average was 4.79 (standard deviation [SD] ± 2.50), with 4.19 (SD ± 1.72) among the children without adenotonsillar hypertrophy, and 6.5 (SD ± 3.40) among the children with adenotonsillar hypertrophy. There was also a statistical significance in the control group. The average was 5.23 (SD ± 2.81), with 4.44 (SD ± 2.2) among the children without adenotonsillar hypertrophy, and 7.87 (SD ± 2.89) among the children with adenotonsillar hypertrophy. Conclusion Adenotonsillar hypertrophy was not associated with sickle cell disease in pre-school children. The subscale of sleep-disordered breathing in the Sleep Disturbance Scale for Children was a useful tool for the diagnostic suspicion of adenotonsillar hypertrophy in children in this age group.

scholarly journals Clinical and laboratory findings associated with sleep disordered breathing in sickle cell disease

2017 ◽  
Vol 92 (12) ◽  
pp. E649-E651 ◽  
Author(s):  
Christopher M. Worsham ◽  
Stephon T. Martin ◽  
Syed-Mehdi Nouraie ◽  
Robyn T. Cohen ◽  
Elizabeth S. Klings
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sleep Disordered Breathing ◽  
Cell Disease ◽  
Laboratory Findings ◽  
Disordered Breathing

Nocturnal Enuresis in Pediatric Sickle Cell Disease

2001 ◽  
Vol 22 (5) ◽  
pp. 300-305 ◽  
Author(s):  
LAMIA P. BARAKAT ◽  
KIM SMITH-WHITLEY ◽  
SETH SCHULMAN ◽  
DANIEL ROSENBERG ◽  
RUPA PURI ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Nocturnal Enuresis ◽  
Cell Disease ◽  
Pediatric Sickle Cell Disease

scholarly journals A Pilot Study of Sleep Disordered Breathing (SDB) and Nocturnal Hypoxemia in Young Adults with Sickle Cell Disease

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 3414-3414
Author(s):  
Susan P. Perrine ◽  
Oluwakemi Owoyemi ◽  
Elizabeth S Klings ◽  
Mehdi Nouraie ◽  
Angela Rock ◽  
...  
Keyword(s):  
Young Adults ◽  
Young Adult ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sleep Disordered Breathing ◽  
Oxygen Desaturation ◽  
Cell Disease ◽  
Nocturnal Hypoxemia ◽  
Minute Walk ◽  
Disordered Breathing

Abstract Sleep disordered breathing including transient hypoxemia and hypercarbia are reported in 60-80% of adolescents and children with sickle cell disease (SCD); oxygen desaturation <93% is associated with exercise intolerance. Longer duration of oxygen desaturation, lower nadirs of oxygenation, and end-tidal carbon dioxide levels >50 mm Hg during sleep are associated with increased frequency of acute vaso-occlusion events and are suspected of contributing to microvasculature alterations. To assess the prevalence and degree of sleep-related hypoxemia and potential associations with cardiovascular functions in young adults with SCD, we performed overnight sleep studies using a Type II sleep monitor NOX-T3 (Carefusion, Inc), 6-minute walk tests, echocardiograms, hematologic and chemistry panels, and PSQI questionnaires in 17 adults with SCD, ages 21-30 years. Subjects were attending a sickle cell clinic solely for routine care with no expressed complaints of SDB. Exclusion criteria included acute clinical events, hospitalizations, or red cell transfusions within 4 weeks, and chronic transfusions. AHI>5 (significant apnea/hypopnea hypoxemic episodes) during sleep occurred in 7/17 (41%) of subjects, and these subjects had a higher median number of hypopneas (34 vs 12, p=0.005), and oxygen desaturation indices (ODI, 5.9 vs 2.0, p<0.001) than occurred in subjects with AHI scores ≤5, with a trend to lower oxygen saturation during sleep (lowest saturation of 78% vs 88%, P = 0.1). Patient-reported symptoms of SDB on the PSQI questionnaire were strongly associated with nocturnal hypoxemia (Sensitivity = 86%). All subjects had 6-minute walk distances below normal for healthy subjects, (mean 384 vs normal adult 876 meters). Left ventricular diastolic function was more affected in patients with AHI>5 (median MV EA ratio of 2.0 vs. 1.5, p = 0.08). TR jet velocity >2.5 was found in 2/17 asymptomatic subjects; (both were in the AHI>5 group). General quality of life was lower in patients with AHI>5 (mean score of 38 vs. 48, p = 0.012). As prolonged and frequent hypoxemic episodes may increase risks for vaso-occlusive, cardiovascular, and neurologic events, these common findings of significant nocturnal hypoxemia in young adult sickle cell subjects strongly suggest that SDB should be investigated further in larger patient populations, and interventions initiated. The observations, in addition to prior reports, also strongly suggest that screening of young adult SCD patients for SDB should be performed on a routine basis. Research reported in this publication was supported by the NHLBI under Award Number P50HL118006. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Disclosures Klings: Actelion Pharmaceuticals: Research Funding; Pfizer: Consultancy.

scholarly journals THE BURDEN OF SLEEP DISORDERED BREATHING IN CHILDREN WITH SICKLE CELL DISEASE

2021 ◽  
Author(s):  
Ilaria Liguoro ◽  
Michele Arigliani ◽  
Hui-leng Tan ◽  
Atul Gupta
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sleep Disordered Breathing ◽  
Selection Process ◽  
Specific Treatment ◽  
Acute Chest Syndrome ◽  
Clinical Implications ◽  
Cell Disease ◽  
Increased Risk ◽  
Disordered Breathing

Children with sickle cell disease (SCD) have an increased risk of sleep disordered breathing (SDB) compared with the general pediatric population. There has been a growing research interest on this field in recent years, yet many questions regarding risk factors and clinical implications of SDB remain unclear. The aim of this review is to provide a concise narrative and systematic synthesis of the available evidence on the epidemiology, clinical presentation, complications and management, of SDB in children with SCD. An electronic search was conducted on studies published from the 1st of January 2000 to the 31st of December 2020 in PubMed/Medline, Scopus and Cochrane databases. All studies focusing on SDB in children with SCD aged from 0 to 20 years were included. Studies were eligible for inclusion if available in the English language. A quantitative synthesis of the included studies was performed. Only studies focusing on specific treatment outcomes were included in a meta-analytic process. A total of 190 papers were initially identified. After screening the title and abstract, 112 articles were evaluated for eligibility. At the end of the selection process, 62 studies were included in the analysis. Sleep-disordered breathing is associated with worse neurological, neurocognitive and cardiological outcomes, whereas the association with frequency or severity of vaso-occlusive pain events and acute chest syndrome was not clarified. Therapeutic interventions like adenotonsillectomy or oxygen supply may result in a significant increase in mean nocturnal oxygen saturation but effective clinical implications remain still unclear.

The problems in evaluation of sleep disordered breathing in adults with sickle cell disease

2020 ◽  
Vol 71 ◽  
pp. 161 ◽  
Author(s):  
S. Roizenblatt ◽  
S.M.G.P. Togeiro ◽  
A.C. Cabanas-Pedro ◽  
M.S. Figueredo
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sleep Disordered Breathing ◽  
Cell Disease ◽  
Disordered Breathing
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