Reinforcement of position preference by automatic intravenous injections of glucose.

The effects of radioimmunotherapy were tested in xenografts of 2 different human pancreatic carcinomas comparing the intravenous and intratumoral application. On principle, intravenous injections of high doses of 131l-anti- Ca 19-9 or -BW 494/32 may inhibit tumor growth. In view of the low direct radiation dose (360-2100 rad), however, other factors than direct toxic effects have to be discussed, e. g. systemic effects due to the high whole-body irradiation. Intratumoral application, however, may induce tumor regression or growth inhibition due to the high local irradiation dose. Consequently, this treatment modality might be of clinical value at least in some patients.

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Liquoid Induced Stasis and the Generalized Shwartzman Reaction

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646840 ◽

1979 ◽

Vol 41 (04) ◽

pp. 804-810 ◽

Cited By ~ 1

Author(s):

Knut Nordstoga

Keyword(s):

Red Cells ◽

Renal Lesions ◽

Intravenous Injections ◽

Shwartzman Reaction ◽

Glomerular Capillaries

SummaryThe composition of the occlusive material within dilated glomerular capillaries, following intravenous injections of Liquoid in blue foxes, was studied electron microscopically; it was found that it mainly consisted of a debris in which disintegrated red cells constituted the major component. Damaged platelets and necrotic endothelial remnants were other components. These observations were interpreted as a result of glomerular stasis, and it was concluded that stasis in glomerular capillaries is a basic event in the development of the renal lesions accompanying the generalized Shwartzman reaction.

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Effects of Vancomycin on Platelets, Plasma Proteins and Hepatitis B Surface Antigen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651448 ◽

1975 ◽

Vol 34 (01) ◽

pp. 083-093 ◽

Cited By ~ 2

Author(s):

Barry S Coller ◽

W. B Lundberg ◽

Harvey R Gralnick

Keyword(s):

Hepatitis B ◽

Factor Viii ◽

Surface Antigen ◽

Plasma Proteins ◽

Hepatitis B Surface Antigen ◽

Infusion Site ◽

Vancomycin Therapy ◽

Intravenous Injections ◽

Low Concentrations ◽

High Doses

SummaryThe antibiotic vancomycin shares many similarities with ristocetin, an agent noted for its effects on platelets and plasma fibrinogen. Vancomycin did not aggregate platelets as ristocetin, but platelets were incorporated into precipitates induced by vancomycin. Fibrinogen and factor VIII were precipitated from plasma at low concentrations of vancomycin. The precipitated fibrinogen remained clottable. Hepatitis B surface antigen was selectively precipitated from serum and could be recovered from the precipitate. Rabbits receiving bolus intravenous injections of high doses of vancomycin developed hypofibrinogenemia and thrombocytopenia within minutes and often went on to die. Studies with 125I-vancomycin revealed little stable binding of the antibiotic to platelets or fibrinogen. A relationship is suggested between the potent protein precipitating effects and phlebitis at the infusion site commonly associated with vancomycin therapy.

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Predicting the Dose of Warfarin for Therapeutic Anticoagulation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657174 ◽

1982 ◽

Vol 47 (03) ◽

pp. 230-231 ◽

Cited By ~ 8

Author(s):

N K Sharma ◽

P A Routledge ◽

M D Rawlins ◽

D M Davies

Keyword(s):

Therapeutic Range ◽

Significant Relationship ◽

Maintenance Dose ◽

Warfarin Dose ◽

Loading Dose ◽

Intravenous Injections ◽

Therapeutic Anticoagulation ◽

Close Relationship ◽

The Relationship ◽

Anticoagulant Response

SummaryThe validity of a previously described technique for predicting warfarin requirements based on the anticoagulant response to a fixed loading dose was assessed prospectively in 57 patients. There was a close relationship between the predicted and initially observed daily warfarin dose required to maintain the patient within the therapeutic range for anticoagulation. The significant relationship between predicted and observed maintenance dose persisted at 4 and 12 weeks although it decreased with increasing time.The relationship between observed and predicted maintenance requirement of warfarin was not affected by the concomitant use of intermittent intravenous injections of heparin when 9 hr was allowed to elapse between the previous dose of heparin and the thrombotest estimation on which the prediction was based.It is concluded that the method is valuable in predicting an individual’s warfarin requirement, although it does not obviate the need for regular monitoring of anticoagulant control.

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THERAPIE EINES METASTASIERENDEN INSELZELLTUMORS MIT STREPTOZOTOCIN

Acta Endocrinologica ◽

10.1530/acta.0.0670405 ◽

1971 ◽

Vol 67 (2) ◽

pp. 405-416 ◽

Cited By ~ 8

Author(s):

E. Nieschlag ◽

H. Wombacher ◽

F. J. Kroeger ◽

L.V. Habighorst

Keyword(s):

Liver Metastases ◽

Blood Sugar ◽

Mechanism Of Action ◽

Islet Cell ◽

Plasma Insulin ◽

Severe Hypoglycaemia ◽

Islet Cells ◽

Intravenous Injections ◽

High Affinity ◽

Methyl Nitrosourea

A patient with a metastazing functional islet cell tumour suffering from severe hypoglycaemia was treated with streptozotocin. Four intravenous injections of 1.5 g streptozotocin each were administered in 4 to 6 days intervals. After the 4th injection there were no further episodes of hypoglycaemia, parenteral glucose administration could be stopped and blood sugar and plasma insulin, showing concentrations of up to 405 μU/ml before treatment, reached normal levels. The tumours in the pancreas disappeared and the liver metastases decreased in size and number as judged by arteriography. A hypothesis for the mechanism of action of streptozotocin is proposed. The glucose moiety is considered to facilitate a high affinity to the islet cells whereas the N-methyl-nitrosourea residue serves the active antitumour part of the molecule.

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