The role of the anterior prefrontal cortex in human cognition

Nature ◽  
10.1038/20178 ◽  
1999 ◽  
Vol 399 (6732) ◽  
pp. 148-151 ◽  
Author(s):  
Etienne Koechlin ◽  
Gianpaolo Basso ◽  
Pietro Pietrini ◽  
Seth Panzer ◽  
Jordan Grafman
Keyword(s):  
Prefrontal Cortex ◽  
Human Cognition ◽  
Anterior Prefrontal Cortex

scholarly journals Interpersonal Synchrony Special Issue The role of anterior prefrontal cortex (area 10) in face-to-face deception measured with fNIRS

2020 ◽  
Author(s):  
Paola Pinti ◽  
Andrea Devoto ◽  
Isobel Greenhalgh ◽  
Ilias Tachtsidis ◽  
Paul W Burgess ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Near Infrared ◽  
Brain Activity ◽  
Lie Detection ◽  
Brain Activation ◽  
Functional Near Infrared Spectroscopy ◽  
Face To Face ◽  
Interpersonal Synchrony ◽  
Anterior Prefrontal Cortex

Abstract Anterior prefrontal cortex (PFC, Brodmann area 10) activations are often, but not always, found in neuroimaging studies investigating deception, and the precise role of this area remains unclear. To explore the role of the PFC in face-to-face deception, we invited pairs of participants to play a card game involving lying and lie detection while we used functional near infrared spectroscopy (fNIRS) to record brain activity in the PFC. Participants could win points for successfully lying about the value of their cards or for detecting lies. We contrasted patterns of brain activation when the participants either told the truth or lied, when they were either forced into this or did so voluntarily and when they either succeeded or failed to detect a lie. Activation in the anterior PFC was found in both lie production and detection, unrelated to reward. Analysis of cross-brain activation patterns between participants identified areas of the PFC where the lead player’s brain activity synchronized their partner’s later brain activity. These results suggest that during situations that involve close interpersonal interaction, the anterior PFC supports processing widely involved in deception, possibly relating to the demands of monitoring one’s own and other people’s behaviour.

The role of anterior prefrontal cortex in adolescents prone to psychosis

2011 ◽  
Vol 26 ◽  
pp. e52
Author(s):  
Annalaura Lagioia ◽  
Martin Debbane ◽  
Maude Schneider ◽  
Stephan Eliez
Keyword(s):  
Prefrontal Cortex ◽  
Anterior Prefrontal Cortex

scholarly journals Integration in Working Memory: A Magnetic Stimulation Study on the Role of Left Anterior Prefrontal Cortex

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43731 ◽  
Author(s):  
Nicola De Pisapia ◽  
Marco Sandrini ◽  
Todd S. Braver ◽  
Luigi Cattaneo
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Magnetic Stimulation ◽  
Anterior Prefrontal Cortex

scholarly journals Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning

2000 ◽  
Vol 97 (13) ◽  
pp. 7651-7656 ◽  
Author(s):  
E. Koechlin ◽  
G. Corrado ◽  
P. Pietrini ◽  
J. Grafman
Keyword(s):  
Prefrontal Cortex ◽  
Anterior Prefrontal Cortex

scholarly journals Causal evidence for mnemonic metacognition in human precuneus

2018 ◽  
Author(s):  
Qun Ye ◽  
Futing Zou ◽  
Hakwan Lau ◽  
Yi Hu ◽  
Sze Chai Kwok
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Parietal Lobe ◽  
Functional Neuroimaging ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Brain Regions ◽  
Neural Basis ◽  
Anterior Prefrontal Cortex

AbstractMetacognition is the capacity to introspectively monitor and control one’s own cognitive processes. Previous anatomical and functional neuroimaging findings implicated the important role of precuneus in metacognition processing, especially during mnemonic tasks. However, the issue of whether this medial parietal cortex is a domain-specific region that supports mnemonic metacognition remains controversial. Here, we focally disrupted this parietal area with repetitive transcranial magnetic stimulation in healthy participants of both sexes, seeking to ascertain its functional necessity for metacognition for memory versus perceptual decisions. Perturbing the precuneal activity impaired the metacognitive efficiency selectively in the memory judgment of temporal-order, but not in perceptual discrimination. Moreover, the correlation in individuals’ metacognitive efficiency between the domains disappeared when the precuneus was perturbed. Together with the previous finding that lesion to the anterior prefrontal cortex impairs perceptual but not mnemonic metacognition, we double dissociated the macro-anatomical underpinnings for the two kinds of metacognitive capacity in an interconnected network of brain regions.SIGNIFICANCE STATEMENTTheories on the neural basis of metacognition have thus far largely centered on the role of prefrontal cortex. Here we refined the theoretical framework through characterizing a unique precuneal involvement in mnemonic metacognition with a noninvasive but inferentially powerful method: transcranial magnetic stimulation. By quantifying meta-cognitive efficiency across two distinct domains (memory vs. perception) that are matched for stimulus characteristics, we reveal an instrumental – and highly selective – role of the precuneus in mnemonic metacognition. These causal evidence corroborate ample clinical reports that parietal lobe lesions often produce inaccurate self-reports of confidence in memory recollection and establish that the precuneus as a nexus for the introspective ability to evaluate the success of memory judgment in humans.

The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease

2020 ◽  
Vol 96 ◽  
pp. 117-127
Author(s):  
Federico Massa ◽  
Stefano Grisanti ◽  
Andrea Brugnolo ◽  
Elisa Doglione ◽  
Beatrice Orso ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prefrontal Cortex ◽  
Prospective Memory ◽  
Fdg Pet ◽  
Early Alzheimer’S Disease ◽  
Anterior Prefrontal Cortex

scholarly journals Distinct Roles for Lateral and Medial Anterior Prefrontal Cortex in Contextual Recollection

2005 ◽  
Vol 94 (1) ◽  
pp. 813-820 ◽  
Author(s):  
Jon S. Simons ◽  
Sam J. Gilbert ◽  
Adrian M. Owen ◽  
Paul C. Fletcher ◽  
Paul W. Burgess
Keyword(s):  
Prefrontal Cortex ◽  
Functional Mri ◽  
Contextual Information ◽  
Retrieval Process ◽  
Detailed Characterization ◽  
Anterior Prefrontal Cortex ◽  
List Memory

A key feature of human recollection is the ability to remember details of the context in which events were experienced, as well as details of the events themselves. Previous studies have implicated a number of regions of prefrontal cortex in contextual recollection, but the role of anterior prefrontal cortex has so far resisted detailed characterization. We used event-related functional MRI (fMRI) to contrast recollection of two forms of contextual information: 1) decisions one had previously made about stimuli (task memory) and 2) which of two temporally distinct lists those stimuli had been presented in (list memory). In addition, a retrieval cue manipulation permitted evaluation of the stage of the retrieval process in which the activated regions might be involved. The results indicated that anterior prefrontal cortex responded significantly more during recollection of task than list context details. Furthermore, activation profiles for lateral and medial aspects of anterior prefrontal cortex suggested differing roles in recollection. Lateral regions seem to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification).

On the role of the anterior prefrontal cortex in cognitive ‘branching’: An fMRI study

2015 ◽  
Vol 77 ◽  
pp. 421-429 ◽  
Author(s):  
George Chahine ◽  
Esther Kristina Diekhof ◽  
Alexandra Tinnermann ◽  
Oliver Gruber
Keyword(s):  
Prefrontal Cortex ◽  
Fmri Study ◽  
Anterior Prefrontal Cortex
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