scholarly journals Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells

1997 ◽  
Vol 75 (9) ◽  
pp. 1330-1335 ◽  
Author(s):  
J Budworth ◽  
TW Gant ◽  
A Gescher
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Multidrug Resistance ◽  
Protein Kinase ◽  
Breast Carcinoma ◽  
Carcinoma Cells ◽  
Multidrug Resistance Gene ◽  
Breast Carcinoma Cells ◽  
Kinase C ◽  
Mcf 7

scholarly journals Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells

Oncogene ◽  
2004 ◽  
Vol 23 (26) ◽  
pp. 4614-4623 ◽  
Author(s):  
Fen Yin ◽  
Dennis Bruemmer ◽  
Florian Blaschke ◽  
Willa A Hsueh ◽  
Ronald E Law ◽  
...  
Keyword(s):  
Gene Expression ◽  
Breast Carcinoma ◽  
Signaling Pathways ◽  
Carcinoma Cells ◽  
Breast Carcinoma Cells ◽  
Mcf 7

scholarly journals DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Mianjie Lin ◽  
Ya-Nan Wang ◽  
Yixin Ye ◽  
Zhelei Xiong ◽  
Fengbiao Guo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Breast Carcinoma ◽  
Differential Gene Expression ◽  
Regulatory Network ◽  
Carcinoma Cells ◽  
Breast Carcinoma Cells ◽  
Differential Gene ◽  
Geo Database ◽  
Mcf 7

Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated with ERBB4. We used the GEO2R tool to compare differential gene expression of MCF-7 cells, following ESR1 knockdown (GEO database, E-GEOD-27473 array), and found decreased expression of DNAJC12 and ERBB4 in ESR1-silenced MCF-7 cells. The number of identical genes having correlativity with ESR1, DNAJC12, or ERBB4 was 12,165 (66.41%). These results suggest that ESR1 can promote the expression of DNAJC12 and ERBB4, and DNAJC12 can enhance the expression of ERBB4 in MCF-7 cells, implying that there may be a regulatory network among these three genes.

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