scholarly journals Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer’s disease

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Ramu Venkatesan ◽  
Yong Un Park ◽  
Eunhee Ji ◽  
Eui-Ju Yeo ◽  
Sun Yeou Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Neuroblastoma Cells ◽  
Membrane Permeabilization ◽  
Apoptotic Cell Death ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization

scholarly journals Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3388
Author(s):  
Kyoung-jin Min ◽  
Taeg Kyu Kwon
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Ectopic Expression ◽  
Glioma Cells ◽  
Membrane Permeabilization ◽  
Apoptotic Cell Death ◽  
Lysosomal Membrane ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Lysosomal Membrane Permeabilization

FTY720, a sphingosine-1-phosphate (S1P) receptor modulator, is a synthetic compound produced by the modification of a metabolite from I. sinclairii. Here, we found that FTY720 induced non-apoptotic cell death in human glioma cells (U251MG, U87MG, and U118MG). FTY720 (10 µM) dramatically induced cytoplasmic vacuolation in glioma cells. However, FTY720-mediated vacuolation and cell death are not associated with autophagy. Genetic or pharmacological inhibition of autophagy did not inhibit FTY720-induced cell death. Herein, we detected that FTY720-induced cytoplasmic vacuoles were stained with lysotracker red, and FTY720 induced lysosomal membrane permeabilization (LMP). Interestingly, cathepsin inhibitors (E64D and pepstatin A) and ectopic expression of heat shock protein 70 (HSP70), which is an endogenous inhibitor of LMP, markedly inhibited FTY720-induced cell death. Our results demonstrated that FTY720 induced non-apoptotic cell death via the induction of LMP in human glioma cells.

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease

2003 ◽  
Vol 66 (8) ◽  
pp. 1627-1634 ◽  
Author(s):  
Anne Eckert ◽  
Uta Keil ◽  
Celio A. Marques ◽  
Astrid Bonert ◽  
Claudia Frey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Increased Apoptotic Cell Death in Sporadic and Genetic Alzheimer's Disease

2003 ◽  
Vol 1010 (1) ◽  
pp. 604-609 ◽  
Author(s):  
ANNE ECKERT ◽  
CELIO A. MARQUES ◽  
UTA KEIL ◽  
KATRIN SCHÜSSEL ◽  
WALTER E. MÜLLER
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 ◽  
Vol 133 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Georgeann Smale ◽  
Nancy R. Nichols ◽  
Daniel R. Brady ◽  
Caleb E. Finch ◽  
Walter E. Horton
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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