scholarly journals Apoptotic Cell Death in Neurons and Glial Cells: Implications for Alzheimer’s Disease

1999 ◽  
Vol 79 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Kitamura Yoshihisa ◽  
Taniguchi Takashi ◽  
Shimohama Shun
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Glial Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease

2003 ◽  
Vol 66 (8) ◽  
pp. 1627-1634 ◽  
Author(s):  
Anne Eckert ◽  
Uta Keil ◽  
Celio A. Marques ◽  
Astrid Bonert ◽  
Claudia Frey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Increased Apoptotic Cell Death in Sporadic and Genetic Alzheimer's Disease

2003 ◽  
Vol 1010 (1) ◽  
pp. 604-609 ◽  
Author(s):  
ANNE ECKERT ◽  
CELIO A. MARQUES ◽  
UTA KEIL ◽  
KATRIN SCHÜSSEL ◽  
WALTER E. MÜLLER
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 ◽  
Vol 133 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Georgeann Smale ◽  
Nancy R. Nichols ◽  
Daniel R. Brady ◽  
Caleb E. Finch ◽  
Walter E. Horton
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

scholarly journals Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41776 ◽  
Author(s):  
Sheila K. Pirooznia ◽  
Jessica Sarthi ◽  
Ashley A. Johnson ◽  
Meridith S. Toth ◽  
Kellie Chiu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Disease Model ◽  
Apoptotic Cell Death

The Potential Role of Ferroptosis in Alzheimer’s Disease

2021 ◽  
Vol 80 (3) ◽  
pp. 907-925
Author(s):  
Guimei Zhang ◽  
Yaru Zhang ◽  
Yanxin Shen ◽  
Yongchun Wang ◽  
Meng Zhao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Peroxidation ◽  
Cell Death ◽  
Iron Metabolism ◽  
Apoptotic Cell ◽  
Potential Interaction ◽  
Underlying Mechanisms ◽  
And Oxidative Stress

Alzheimer’s disease (AD) is the most prevalent cause of dementia, accounting for approximately 60%–80%of all cases. Although much effort has been made over the years, the precise mechanism of AD has not been completely elucidated. Recently, great attention has shifted to the roles of iron metabolism, lipid peroxidation, and oxidative stress in AD pathogenesis. We also note that these pathological events are the vital regulators of a novel regulatory cell death, termed ferroptosis—an iron-dependent, oxidative, non-apoptotic cell death. Ferroptosis differs from apoptosis, necrosis, and autophagy with respect to morphology, biochemistry, and genetics. Mounting evidence suggests that ferroptosis may be involved in neurological disorders, including AD. Here, we review the underlying mechanisms of ferroptosis; discuss the potential interaction between AD and ferroptosis in terms of iron metabolism, lipid peroxidation, and the glutathione/glutathione peroxidase 4 axis; and describe some associated studies that have explored the implication of ferroptosis in AD.

Shiga toxin-2 enhances heat-shock-induced apoptotic cell death in cultured and primary glial cells

2014 ◽  
Vol 30 (5) ◽  
pp. 289-299 ◽  
Author(s):  
Naotoshi Sugimoto ◽  
Tomoko Toma ◽  
Masaki Shimizu ◽  
Mondo Kuroda ◽  
Taizo Wada ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Glial Cells ◽  
Shiga Toxin ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Shiga Toxin 2
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