The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy: a case–control study

Purpose:A case-control study to explore the diurnal variation of blood pressure (BP) in patients with central serous chorioretinopathy (CSCR).Methods:One-hundred patients (50 cases with central serous chorioretinopathy and 50 age- and sex-matched controls) participated in this study. Twenty-four-hour BP was recorded by auscultatory method using manual standard mercury sphygmomanometer by a single, trained observer. Hypertension was categorised according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VII) classification.Results:Mean systolic BP (SBP) and diastolic BP (DBP) in cases and controls were 123.4 mmHg (range 112.3134.6), 81.72 mmHg (range 73.090.5); 118.33 mmHg (range 108.4128.2); and 77.50 mmHg (range 71.483.6), respectively. The difference in SBP and DBP was statistically significant at p=0.02 for the former and p=0.006 for the latter. The mean difference in maximum and minimum SBP in cases was 18 (±15.81) mmHg versus 9.04 (±3.08) mmHg in controls (p=0.001). Mean difference for DBP in cases was 15.16 (±7.86) mmHg versus 9.16 (±3.68) mmHg in controls (0.001). On the JNC-VII classification scale for hypertension, 66 % of cases were found to be pre-hypertensive (60 %) or hypertensive (6 %). Comparative figures for controls were pre-hypertension (30 %) and hypertension (2 %). The mean SBP and DBP was consistently higher in patients with CSCR compared with controls over the entire 24-hour period. The difference in variation between maximum and minimum SBP and DBP was also found to be statistically significant between the groups.Conclusion:A significant correlation exists between higher values BP and central serous chorioretinopathy. Screening of CSCR patients for pre-hypertension may be useful in decreasing the risk of progression to established hypertension, with its associated risks.

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Temperament Profile in Patients with Central Serous Chorioretinopathy: A Case-Control Study

European Journal of Ophthalmology ◽

10.5301/ejo.5000377 ◽

2014 ◽

Vol 24 (3) ◽

pp. 392-395 ◽

Cited By ~ 9

Author(s):

Małgorzata Piskunowicz ◽

Marcin Jaracz ◽

Hanna Lesiewska ◽

Grażyna Malukiewicz ◽

Marzenna Brożek-Pestka ◽

...

Keyword(s):

Central Serous Chorioretinopathy ◽

Case Control Study ◽

Case Control ◽

Control Study

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Risk Factors for Central Serous Chorioretinopathy: A Case-Control Study

Medicina ◽

10.29234/2308-9113-2020-8-2-81-93 ◽

2020 ◽

Vol 8 (2) ◽

pp. 81-93

Author(s):

G. R. Khasanova ◽

◽

D. R. Аgliullin ◽

E. A. Abdulaeva ◽

L. R. Kagirova ◽

...

Keyword(s):

Risk Factors ◽

Arterial Hypertension ◽

Central Serous Chorioretinopathy ◽

Protective Factor ◽

Case Control Study ◽

Significant Risk ◽

Case Control ◽

Industrial City ◽

Corticosteroid Drugs ◽

Control Study

Aim of the study: Assessment of the influence of potential risk factors on the development of central serous chorioretinopathy in a large industrial city. Materials and Methods: Case-control study of persons aged 18 years and older. The study group included 100 patients with central serous chorioretinopathy, confirmed by optical coherence tomography, and controls – 100 patients without central serous chorioretinopathy. The groups are comparable in gender and age. Interviewing of patients was carried out according to the developed questionnaire, including 33 questions. One-way and multivariate analysis of the results using logistic regression was carried out. Statistical data processing was carried out using Microsoft Office Excel 2010, Jamovi programs, R – Studio statistical package, OpenEpi online calculators (http://www.openepi.com). Results: The following risk factors for CSC were identified: taking corticosteroid drugs in the last year – OR 13.5; 95% CI 3.4-53.2 and the presence of arterial hypertension – OR 8.3; 95% CI 1.3-54.1. Intake of antihypertensive drugs and psychotropic drugs from the group of anxiolytics were statistically significant factors in the "prevention" of the development of CSC (OR 0.1; 95% CI 0.02-0.9 and OR 0.01; 95% CI 0.0003− 0.5), respectively. The presence of myopia also proved to be a protective factor for CSC –OR 0.3; 95% CI 0.14-0.8. Conclusion: In a case-control study, significant risk factors for CSC for the population of a large industrial city were arterial hypertension and the use of corticosteroid drugs. The presence of myopia is associated with a lower incidence of CSC.

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Intima-Media Thickness Measurements of the Common Carotid Artery in Patients with Central Serous Chorioretinopathy: A Case-Control Study

Journal of Ophthalmology ◽

10.1155/2021/6652373 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Kobra Nasrollahi ◽

Amirhossein Farahi ◽

Fatemeh Paknazar ◽

Mohamadreza Akhlaghi ◽

Farhad Fazel ◽

...

Keyword(s):

Central Serous Chorioretinopathy ◽

Case Control Study ◽

Intima Media Thickness ◽

Case Control ◽

Control Group ◽

Media Thickness ◽

Left And Right ◽

The Difference ◽

The Right ◽

Control Study

Purpose. To evaluate the intima-media thickness (IMT) of the left and right common carotid arteries (CCA) as an indicator of subclinical atherosclerosis in patients with central serous chorioretinopathy (CSCR). Methods. This was a case-control study involving patients with CSCR and a matched healthy control group. The mean and difference of the left and right CCA IMT were determined and compared between the two groups using carotid duplex high-resolution B-mode ultrasound equipment. Results. The study enrolled 32 CSCR patients (68.8% female, mean age 38.22 ± 5.42 years) and 32 controls (65.6% female, mean age 39.56 ± 5.33 years). The difference in common carotid IMT between the right and left sides was significantly greater in the CSCR group than in the control group ( p < 0.001 ). Additionally, according to logistic regression analysis, patients with CSCR had a greater chance of having differences in IMT between the two sides when compared to the control group (OR: 1.29, 95% CI: 1.09–1.52). Conclusion. Our findings indicated that in the CSCR group, the difference between the right and left sides of CCA IMT was significantly greater than in the control group.

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Systemic evaluation of patients with central serous chorioretinopathy: A case-control study

European Journal of Ophthalmology ◽

10.1177/1120672120975698 ◽

2020 ◽

pp. 112067212097569

Author(s):

Devesh Kumawat ◽

Alok Kumar Ravi ◽

Pranita Sahay ◽

Tanveer Alam ◽

Arjun Desai ◽

...

Keyword(s):

Alcohol Use ◽

Central Serous Chorioretinopathy ◽

Sleep Disturbances ◽

Case Control Study ◽

Univariate Analysis ◽

Case Control ◽

Psychological Disorder ◽

Ophthalmological Examination ◽

Unit Increase ◽

Control Study

Objective: To investigate the systemic associations of central serous chorioretinopathy (CSCR) with help of clinical and biochemical investigations. Design: Case-control study. Participants: Eighty seven CSCR patients (case) and 82 Asian-Indian patients with primary non-traumatic rhegmatogenous retinal detachment (control) were recruited between July 2017 and December 2018 at a tertiary eye-care center in North India. Methods: The patients underwent ophthalmological examination and systemic evaluation based on history and biochemical investigations. Logistic regression was performed to identify the associations of CSCR. Results: The age was similar between cases and controls (36.9 ± 7.8 years vs 35.7 ± 10.8 years, p = 0.38). On univariate analysis, the significant factors with higher odds of CSCR were alcohol use (odds ratio, OR: 3.4; 95% confidence interval: 1.36–8.53), sleep disturbance (OR: 5.44; 1.76–16.8), gastroesophageal reflux (OR: 9.34; 1.15–75.50), psychological disorder (OR: 5.78; 1.24–26.97), tuberculosis history (OR: 8.2; 1.0–67.10), serum albumin: globulin ratio (AGR) > 2 (OR: 10.43; 2.33–46.57), and serum hemoglobin (per unit increase; OR: 1.35; 1.14–1.61). Although the mean blood pressure was significantly higher in cases, the distribution among various hypertension categories was not significantly different. Exogenous steroid use and morning 8 am serum cortisol levels were not significantly different between the groups. On multivariable analysis, alcohol use (OR: 4.72; 1.33–16.76), sleep disturbances (OR: 5.04; 1.36–18.70), dysthyroid state (OR: 3.02; 1.04–8.74), serum AGR > 2 (OR: 14.28; 2.33–87.28), and serum hemoglobin (per unit increase; OR: 1.43; 1.13–1.81) were significant independent associations. Conclusion: Other than the previously described associations of CSCR like alcohol use and sleep disturbances, this study reports possible association with deranged serum protein and thyroid hormone profile. Further large-scale prospective studies need to validate these results.

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