scholarly journals Neutralizing circulating ghrelin by expressing a growth hormone secretagogue receptor-based protein protects against high-fat diet-induced obesity in mice

Gene Therapy ◽  
2015 ◽  
Vol 22 (9) ◽  
pp. 750-757 ◽  
Author(s):  
J Gagnon ◽  
L Zhu ◽  
Y Anini ◽  
Q Wang
Keyword(s):  
Growth Hormone ◽  
High Fat Diet ◽  
High Fat ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice

2020 ◽  
Vol 119 ◽  
pp. 104718
Author(s):  
María Paula Cornejo ◽  
Franco Barrile ◽  
Daniela Cassano ◽  
Julieta Paola Aguggia ◽  
Guadalupe García Romero ◽  
...  
Keyword(s):  
Growth Hormone ◽  
High Fat Diet ◽  
Dopamine Neurons ◽  
High Fat ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ad Libitum

scholarly journals Estradiol Replacement Improves High-Fat Diet-Induced Obesity by Suppressing the Action of Ghrelin in Ovariectomized Rats

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 907
Author(s):  
Naoko Yokota-Nakagi ◽  
Haruka Takahashi ◽  
Mizuho Kawakami ◽  
Akira Takamata ◽  
Yuki Uchida ◽  
...  
Keyword(s):  
Growth Hormone ◽  
High Fat Diet ◽  
Ovariectomized Rats ◽  
Mrna Levels ◽  
High Fat ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Protein Levels ◽  
Ovx Rats ◽  
Hypothalamic Arcuate Nucleus

This study aims to investigate the effects of estradiol replacement on the orexigenic action of ghrelin in ovariectomized (OVX) obese rats fed with a high-fat diet (HFD). Four weeks after OVX at 9 weeks of age, Wistar rats were subcutaneously implanted with either 17β-estradiol (E2) or placebo (Pla) pellets and started on HFD feeding. After 4 weeks, growth hormone-releasing peptide (GHRP)-6, a growth hormone secretagogue receptor (GHSR) agonist injected intraperitoneally, induced changes in HFD intake, and c-Fos-positive neurons in the hypothalamic arcuate nucleus (ARC) were measured in both groups. The ghrelin protein and mRNA levels, as well as GHSR protein in stomach, were analyzed by Western blotting and real-time PCR. HFD increased energy intake and body weight in the Pla group, while it temporarily reduced these in the E2 group. GHRP-6 enhanced HFD intake and activated neurons in the ARC only in the Pla group. Furthermore, gastric ghrelin and GHSR protein levels were lower in the E2 group than in the Pla group, but plasma acyl ghrelin levels were similar in both groups. Our results suggest that E2 replacement improves obesity by inhibiting the orexigenic action of ghrelin via downregulation of ghrelin and its receptor in stomach in HFD-fed OVX rats.

An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling

2014 ◽  
Vol 9 ◽  
pp. 211-224 ◽  
Author(s):  
Jihang Chen ◽  
Hoi Shan Wong ◽  
Hoi Yan Leung ◽  
Pou Kuan Leong ◽  
Wing Man Chan ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
High Fat Diet ◽  
High Fat ◽  
Mitochondrial Uncoupling ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Magnesium deficiency prevents high-fat-diet-induced obesity in mice

Diabetologia ◽  
2018 ◽  
Vol 61 (9) ◽  
pp. 2030-2042 ◽  
Author(s):  
Steef Kurstjens ◽  
Janna A. van Diepen ◽  
Caro Overmars-Bos ◽  
Wynand Alkema ◽  
René J. M. Bindels ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Magnesium Deficiency ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

2018 ◽  
Author(s):  
Sarmila Nepali ◽  
Do‑Kuk Kim ◽  
Hoon‑Yeon Lee ◽  
Hyeon‑Hui Ki ◽  
Bo‑Ram Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Combined effects of Diospyros lotus leaf and grape stalk extract in high-fat-diet-induced obesity in mice

2019 ◽  
Vol 28 (4) ◽  
pp. 1207-1215 ◽  
Author(s):  
Denis Nchang Che ◽  
Hyun Ju Kang ◽  
Byoung Ok Cho ◽  
Jae Young Shin ◽  
Seon Il Jang
Keyword(s):  
High Fat Diet ◽  
Combined Effects ◽  
High Fat ◽  
Lotus Leaf ◽  
Diet Induced Obesity ◽  
Diospyros Lotus ◽  
Obesity In Mice

scholarly journals P133Atrial fibrillation vulnerability and action potential shortening in high fat diet-induced obesity in mice

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S34-S34
Author(s):  
V Galand ◽  
N Mougenot ◽  
A Coulombe ◽  
N Suffee-Mosbah ◽  
N Doisne ◽  
...  
Keyword(s):  
Action Potential ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Action Potential Shortening

scholarly journals Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

Diabetes ◽  
2011 ◽  
Vol 60 (10) ◽  
pp. 2465-2473 ◽  
Author(s):  
D. V. Chartoumpekis ◽  
P. G. Ziros ◽  
A. I. Psyrogiannis ◽  
A. G. Papavassiliou ◽  
V. E. Kyriazopoulou ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice
Sign in / Sign up

Export Citation Format

Share Document