Melanocortin-4 receptor signaling is not required for short-term weight loss after sleeve gastrectomy in pediatric patients

Abstract Background It is already known that Laparoscopic sleeve gastrectomy (LSG) has gained popularity as a stand-alone procedure with good short-term results for weight loss. However, in the long-term, weight regain is considered as a complication. Demand for secondary surgery is rising, partly for this reason, but through that study we try to discover the efficacy of conversion of failed sleeve gastrectomy to one anastomosis gastric bypass (OAGB) regarding weight loss and metabolic outcomes. Objective To asses the efficacy and safety of one anastomosis gastric bypass (OAGB) as a conversion surgery post Sleeve Gastrectomy failure as regard weight loss and metabolic outcomes. Patients and Methods This study is a retrospective cohort study which included 20 patients underwent one anastomosis gastric bypass at Ain-Shams University El-Demerdash Hospital, Cairo, Egypt and specialized bariatric center, Cairo, Egypt From February 2019 to July 2019 with 6 months of postoperative follow up till January 2019. Results In this study, we reviewed and analyzed the outcomes from the revision of the SG due to either inadequate weight loss or weight regain to one anastomosis gastric bypass (OAGB) with %EBWL of 6.65% at 1 month, 13.61 % at 3 months and 20.86% at 6 months. Conclusion OAGB appears to be an effective and safe therapeutic technique as a revisional surgery for failed primary SG with good short-term results for treating morbid obesity and its associated comorbidities with a significantly low rate of complications. However the EBWL was less than what is reported after primary OAGB weight. Multicenter studies with larger series of patients and longer term follow up after SG revisions to OAGB are warranted.

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Emotional food cravings predicts poor short‐term weight loss following laparoscopic sleeve gastrectomy

British Journal of Health Psychology ◽

10.1111/bjhp.12302 ◽

2018 ◽

Vol 23 (3) ◽

pp. 532-543 ◽

Cited By ~ 10

Author(s):

Michéle A. Janse Van Vuuren ◽

Esben Strodl ◽

Katherine M. White ◽

Philip D. Lockie

Keyword(s):

Weight Loss ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Short Term ◽

Food Cravings

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Weight and Glycemic Control Outcomes of Bariatric Surgery and Pharmacotherapy in Patients With Melanocortin-4 Receptor Deficiency

Frontiers in Endocrinology ◽

10.3389/fendo.2021.792354 ◽

2022 ◽

Vol 12 ◽

Author(s):

Esphie Grace Fodra Fojas ◽

Saradalekshmi Koramannil Radha ◽

Tomader Ali ◽

Evan P. Nadler ◽

Nader Lessan

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Glycemic Control ◽

Therapeutic Interventions ◽

Control Group ◽

Short Term ◽

Melanocortin 4 Receptor ◽

Significant Difference

BackgroundMelanocortin-4 receptor (MC4R) mutations are the most common of the rare monogenic forms of obesity. However, the efficacy of bariatric surgery (BS) and pharmacotherapy on weight and glycemic control in individuals with MC4R deficiency (MC4R-d) is not well-established. We investigated and compared the outcomes of BS and pharmacotherapy in patients with and without MC4R-d.MethodsPertinent details were derived from the electronic database among identified patients who had BS with MC4R-d (study group, SG) and wild-type controls (age- and sex-matched control group, CG). Short- and long-term outcomes were reported for the SG. Short-term outcomes were compared between the two groups.ResultsSeventy patients were screened for MC4R-d. The SG [six individuals (four females, two males); 18 (10–27) years old at BS; 50.3 (41.8–61.9) kg/m2 at BS, three patients with homozygous T162I mutations, two patients with heterozygous T162I mutations, and one patient with heterozygous I170V mutation] had a follow-up duration of up to 10 years. Weight loss, which varied depending on mutation type [17.99 (6.10–22.54) %] was stable for 6 months; heterogeneity of results was observed thereafter. BS was found superior to liraglutide on weight and glycemic control outcomes. At a median follow-up of 6 months, no significant difference was observed on weight loss (20.8% vs. 23.0%, p = 0.65) between the SG and the CG [eight individuals (four females, four males); 19.0 (17.8–36.8) years old at BS, 46.2 (42.0–48.3) kg/m2 at BS or phamacotherapeutic intervention]. Glycemic control in patients with MC4R-d and Type 2 diabetes improved post-BS.ConclusionOur data indicate efficacious short-term but varied long-term weight loss and glycemic control outcomes of BS on patients with MC4R-d, suggesting the importance of ongoing monitoring and complementary therapeutic interventions.

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Laparoscopic vertical sleeve gastrectomy, long and short-term impact on weight loss and associated co-morbidities

Annals of Translational Medicine ◽

10.21037/atm.2020.01.89 ◽

2020 ◽

Vol 8 (S1) ◽

pp. S5-S5 ◽

Cited By ~ 1

Author(s):

Leena Khaitan ◽

Brian J. Shea

Keyword(s):

Weight Loss ◽

Sleeve Gastrectomy ◽

Vertical Sleeve Gastrectomy ◽

Short Term

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Melanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass Surgery

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2011-3432 ◽

2012 ◽

Vol 97 (6) ◽

pp. E1023-E1031 ◽

Cited By ~ 100

Author(s):

Ida J. Hatoum ◽

Nicholas Stylopoulos ◽

Amanda M. Vanhoose ◽

Kelli L. Boyd ◽

Deng Ping Yin ◽

...

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Receptor Signaling ◽

Melanocortin 4 Receptor

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Laparoscopic Sleeve Gastrectomy as a Primary Operation for Morbid Obesity: Experience with 200 Patients

Gastroenterology Research and Practice ◽

10.1155/2012/801325 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Paolo Gentileschi

Keyword(s):

Morbid Obesity ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Hospital Stay ◽

Laparoscopic Sleeve Gastrectomy ◽

Excess Weight Loss ◽

Gastric Stump ◽

Short Term ◽

Operative Complications

Introduction. Laparoscopic sleeve gastrectomy (LSG) represents a valid option for morbid obesity, either as a primary or as a staged procedure. The aim of this paper is to report the experience of a single surgeon with LSG as a standalone operation for morbid obesity.Methods. From April 2006 to April 2011, 200 patients underwent LSG for morbid obesity. Each patient record was registered and prospectively collected. In July 2011, a retrospective analysis was conducted.Results. Patients were 128 females and 72 males with a median age of 40.0 years. Median pre-operative BMI was 49.4 kg/m2. Median follow-up was 27.2 months. Median post-operative BMI was 30.4 kg/m2. Median %excess weight loss (%EWL) was 63.6%. Median post-operative hospital stay was 4.0 days in the first 84 cases and 3.0 days in the last 116 cases. Six major post-operative complications occurred (3%): two gastric stump leaks (1%), three major bleedings (1.5%) and 1 (0.5%) bowel obstruction. One case of mortality was registered (0.5%). To date only 4 patients are still in the range of morbid obesity (BMI > 35 kg/m2).Conclusions. Laparoscopic sleeve gastrectomy is a formidable operation in the short-term period. Median %EWL in this series was 63.6% at 27.2 months follow-up.

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Short-Term Weight Loss Following Sleeve Gastrectomy in Adolescents with Morbid Obesity vs. Super Obesity

Surgery for Obesity and Related Diseases ◽

10.1016/j.soard.2016.08.127 ◽

2016 ◽

Vol 12 (7) ◽

pp. S82-S83

Author(s):

Jeffrey Zitsman ◽

Erika Breitfeller ◽

Lori Lynch ◽

Jennifer Woo Baidal ◽

Robyn Sysko ◽

...

Keyword(s):

Morbid Obesity ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Short Term ◽

Super Obesity

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Short-Term Results Suggest That Sleeved Stomach without Resection Is as Effective as Sleeve Gastrectomy in Improving Glucose Control in Type 2 Diabetes Mellitus Sprague-Dawley Rat Model

BioMed Research International ◽

10.1155/2020/9024923 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Wenzhuo Zhang ◽

Jason Widjaja ◽

Libin Yao ◽

Yong Shao ◽

Xiaocheng Zhu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Weight Loss ◽

Body Weight ◽

Sleeve Gastrectomy ◽

Food Intake ◽

Glucose Tolerance ◽

Glucose Control ◽

Sprague Dawley ◽

Short Term

Background. Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. Material and Methods. A total of 22 male Sprague-Dawley rats with type 2 diabetes were randomly assigned into 3 different groups: (1) sleeve gastroplasty with gastric remnant-jejunal anastomosis (SGP, n=8); (2) sleeve gastrectomy (SG, n=8); and (3) SHAM (n=6). Body weight, food intake, fasting blood glucose (FBG), hormonal analysis, and oral glucose tolerance test (OGTT) were performed and measured preoperatively and postoperatively. Results. During the postoperative period, SGP and SG showed significantly lower food intake and body weight when compared with the preoperative levels, respectively (p value < 0.05). Postoperatively, SGP and SG showed improvements in FBG and glucose tolerance levels compared to their respective preoperative levels (p<0.05). FBG and glucose tolerance levels did not differ between SGP and SG postoperatively. SG resulted in a reduction in fasting ghrelin levels when compared with the preoperative level (p<0.05). Fasting insulin levels did not differ preoperatively and postoperatively among all groups. Postoperatively, fasting GLP-1 levels were higher in SGP and SG when compared with the preoperative levels, but no statistical significance was observed. Compared preoperatively, the SGP and SG procedures resulted in a decline in HOMA-IR at postoperative 6th week (p<0.05). Conclusion. Our animal experiment suggested that at least in the short term, sleeved stomach without resection resulted in similar weight loss and improved glucose control effects compared to sleeve gastrectomy.

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The role of the surgical resection distance from the pylorus after laparoscopic sleeve gastrectomy: a prospective cohort study from an academic medical center in Egypt

Patient Safety in Surgery ◽

10.1186/s13037-020-00270-6 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Ahmed H. Hussein ◽

Islam Khaled ◽

Mohammed Faisal

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Excess Weight Loss ◽

Excess Weight ◽

Short Term ◽

Weight Loss Percentage ◽

Pylorus Resection

Abstract Background Laparoscopic sleeve gastrectomy was recently described as an effective approach for the operative treatment of obesity, but the ideal procedure remains controversial. One of the most debated issues is the resection distance from the pylorus. We conducted this study to elucidate any potential differences in the short-term outcomes between 2 and 6 cm distance from the pylorus in laparoscopic sleeve gastrectomy. Methods A prospective observational cohort study in a selected cohort of 96 patients was conducted from January 2018 to March 2019 in morbidly obese patients who had laparoscopic sleeve gastrectomy performed at Suez Canal University Hospital. Outcome was expressed by excess weight loss percentage, resolution of comorbidities, improvement of quality of life, and incidence of complications after laparoscopic sleeve gastrectomy. The morbidly obese patients (body mass index [BMI] > 40 kg/m2 or > 35 kg/m2 with obesity-related comorbidities) in the study were divided into two equal groups: (1) Group 1 (48 patients) underwent laparoscopic sleeve gastrectomy with a 2 cm distance from the pylorus resection distance and (2) Group 2 (48 patients) underwent laparoscopic sleeve gastrectomy with a 6 cm distance from the pylorus resection distance. Body weight, BMI, bariatric quality of life, lipid profile, and comorbidities were evaluated pre- and post-operatively for a duration of 12 months. Results Statistically, no significant differences between the two study groups regarding the excess weight loss percentage, comorbidity resolution throughout the postoperative follow-up, enhancement of the quality of life score throughout the postoperative follow-up, or incidence of complications (25% in Group 1 versus 25% in Group 2, p > 0.05) were found. Conclusion Laparoscopic sleeve gastrectomy was an effective and safe management for morbid obesity and obesity-related comorbidities with significant short-term weight loss; it also improved weight-related quality of life and had an acceptable complication rate. The distance from the pylorus resection distance did not affect the short-term effects of laparoscopic sleeve gastrectomy regarding excess weight loss percentage, resolution of comorbidities, change in quality of life, or occurrence of complications.

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