scholarly journals Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica

2007 ◽  
Vol 60 (7) ◽  
pp. 469-472 ◽  
Author(s):  
Ginger Tsueng ◽  
Kin S Lam
Keyword(s):  
Submerged Fermentation ◽  
Proteasome Inhibitor ◽  
Salinispora Tropica ◽  
Stabilization Effect

scholarly journals Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)

2014 ◽  
Vol 86 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Denise Niewerth ◽  
Gerrit Jansen ◽  
Lesley F. V. Riethoff ◽  
Johan van Meerloo ◽  
Andrew J. Kale ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Proteasome Inhibitor ◽  
Antileukemic Activity ◽  
Salinosporamide A ◽  
Salinispora Tropica

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

2017 ◽  
Author(s):  
Carolyn Bertozzi ◽  
Fred Tomlin ◽  
Ulla Gerling-Driessen ◽  
Yi-Chang Liu ◽  
Ryan Flynn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Proteasome Inhibitor ◽  
Activation Mechanism ◽  
Cancer Drugs ◽  
Small Molecule Library ◽  
Library Screen ◽  
In Cells

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

Biosynthesis of L-lysine by Bacillus megaterium through submerged fermentation

2020 ◽  
Vol 52 (6) ◽  
Author(s):  
Amjad Hussain ◽  
Hamid Mukhtar ◽  
Ikram Ul Haq
Keyword(s):  
Bacillus Megaterium ◽  
Submerged Fermentation
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