scholarly journals Biosynthesis of 3′-Deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius Mutant Strain by tacB Gene Disruption

2008 ◽  
Vol 61 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Yonghong Yu ◽  
Xifan Hou ◽  
Xianpu Ni ◽  
Huanzhang Xia
Keyword(s):  
Mutant Strain ◽  
Gene Disruption ◽  
Streptomyces Tenebrarius

Thrombomodulin Gene Disruption and Mutation in Mice

1997 ◽  
Vol 78 (01) ◽  
pp. 705-709 ◽  
Author(s):  
Robert D Rosenberg
Keyword(s):  
Gene Disruption

EFFECT OF NICOTINE ON SEXUAL BEHAVIOUR OF MUTANT STRAIN (CURLED) OF DROSOPHILLA MELANOGASTER

2018 ◽  
Vol 24 (1) ◽  
Author(s):  
SHAMIM AKHTER CHOUDHARY
Keyword(s):  
Mutant Strain ◽  
Sexual Behaviour ◽  
Virgin Female ◽  
P Value ◽  
Pooled Data ◽  
Mating Latency ◽  
Males And Females ◽  
Food Medium ◽  
Food Media ◽  
Dose Dependent

In the present study, an attempt was made to study the effect of plant extract on Sexual behaviour of Mutant Strain (Curled) of Drosophila melanogaster. The LC50 has been estimated with 1% of the food media. The virgin females and males were isolated and fed with normal food media for three days. Then sub-lethal concentrations of 0.625 μl / 100 ml food, 1.2 μl /100 ml food, 2.5μl /100 / food of nicotine were mixed in food medium and allowed in flies to feed for two days. Then appropriate combination of untreated / treated males and females were introduced into the mating chamber. Courtship latency, mating latency and copulation duration were studied. After observation of the behaviour, mated flies were allowed to produce progeny. The sexual behaviour of bachelor male and virgin female obtained in the progeny was also studied. The pooled data were analyzed by student t-test and the result indicates p-value significant at 0.05 levels. The courtship latency was affected by in treatment but it is neither dose dependent nor sex dependent.

Renal Manifestations of Tuberous Sclerosis Complex

2020 ◽  
Vol 7 (3) ◽  
pp. 5-19
Author(s):  
Nikhil Nair ◽  
Ronith Chakraborty ◽  
Zubin Mahajan ◽  
Aditya Sharma ◽  
Sidarth Sethi ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Gene Disruption ◽  
Treatment Guidelines ◽  
Renal Cysts ◽  
Skin Lesions ◽  
Multiple Organ ◽  
Tsc2 Gene ◽  
Genetic Condition ◽  
Organ Systems

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors and seizures. TSC can manifests in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines.

scholarly journals α1-Syntrophin Gene Disruption Results in the Absence of Neuronal-type Nitric-oxide Synthase at the Sarcolemma but Does Not Induce Muscle Degeneration

1999 ◽  
Vol 274 (4) ◽  
pp. 2193-2200 ◽  
Author(s):  
Shuhei Kameya ◽  
Yuko Miyagoe ◽  
Ikuya Nonaka ◽  
Takaaki Ikemoto ◽  
Makoto Endo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gene Disruption ◽  
Muscle Degeneration ◽  
Oxide Synthase ◽  
Neuronal Type
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