Adenosine Deaminase Inhibitors Enhance Cerebral Anoxic Hyperemia in the Rat
1985 ◽
Vol 5
(2)
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pp. 295-299
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Keyword(s):
Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) (1.0–100 μg/kg) and deoxycoformycin (0.1–1 μg/kg) potentiated the reactive hyperemia elicited by a brief (24-s) anoxic challenge. Basal flow rate was unaltered by EHNA administration and slightly enhanced by deoxycoformycin. The results are consistent with the hypothesis that adenosine plays a significant role in cerebral vascular regulation and suggest that low doses of these deaminase inhibitors may be useful in the treatment of cerebral vascular insufficiency.
1987 ◽
Vol 151
(3)
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pp. 261-268
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1992 ◽
Vol 263
(4)
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pp. G487-G493
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2008 ◽
Vol 7
(5-1)
◽
pp. 270-275
Keyword(s):
Keyword(s):
1990 ◽
Vol 258
(2)
◽
pp. H408-H413
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1983 ◽
Vol 3
(2)
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pp. 170-182
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Keyword(s):