Resistance of Optogenetically Evoked Motor Function to Global Ischemia and Reperfusion in Mouse in Vivo
2013 ◽
Vol 33
(8)
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pp. 1148-1152
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Keyword(s):
Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minute period of global ischemia. Our results suggest a differential sensitivity of sensory and motor systems to the effects of global ischemia and reperfusion that may have implications for rehabilitation.
2007 ◽
Vol 51
(7)
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pp. 909-913
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1999 ◽
Vol 57
(2)
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pp. 199-208
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2006 ◽
Vol 84
(6)
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pp. 611-615
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Keyword(s):
2002 ◽
Vol 22
(7)
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pp. 821-834
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