scholarly journals 3D GRASE Pulsed Arterial Spin Labeling at Multiple Inflow Times in Patients with Long Arterial Transit Times: Comparison with Dynamic Susceptibility-Weighted Contrast-Enhanced MRI at 3 Tesla

2015 ◽  
Vol 35 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Steve Z Martin ◽  
Vince I Madai ◽  
Federico C von Samson-Himmelstjerna ◽  
Matthias A Mutke ◽  
Miriam Bauer ◽  
...  
Keyword(s):  
Cerebral Artery ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
3 Tesla ◽  
Acquisition Time ◽  
Dynamic Susceptibility ◽  
Flow Measurements ◽  
Transit Times ◽  
Contrast Enhanced ◽  
Transit Delay

Pulsed arterial spin labeling (PASL) at multiple inflow times (multi-TIs) is advantageous for the measurement of brain perfusion in patients with long arterial transit times (ATTs) as in steno-occlusive disease, because bolus-arrival-time can be measured and blood flow measurements can be corrected accordingly. Owing to its increased signal-to-noise ratio, a combination with a three-dimensional gradient and spin echo (GRASE) readout allows acquiring a sufficient number of multi-TIs within a clinically feasible acquisition time of 5 minutes. We compared this technique with the clinical standard dynamic susceptibility-weighted contrast-enhanced imaging—magnetic resonance imaging in patients with unilateral stenosis >70% of the internal carotid or middle cerebral artery (MCA) at 3 Tesla. We performed qualitative (assessment by three expert raters) and quantitative (region of interest (ROI)/volume of interest (VOI) based) comparisons. In 43 patients, multi-TI PASL-GRASE showed perfusion alterations with moderate accuracy in the qualitative analysis. Quantitatively, moderate correlation coefficients were found for the MCA territory (ROI based: r=0.52, VOI based: r=0.48). In the anterior cerebral artery (ACA) territory, a readout related right-sided susceptibility artifact impaired correlation (ROI based: r=0.29, VOI based: r=0.34). Arterial transit delay artifacts were found only in 12% of patients. In conclusion, multi-TI PASL-GRASE can correct for arterial transit delay in patients with long ATTs. These results are promising for the transfer of ASL to the clinical practice.

Assessment of Irradiated Brain Metastases by Means of Arterial Spin-Labeling and Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MRI

2004 ◽  
Vol 39 (5) ◽  
pp. 277-287 ◽  
Author(s):  
Marc-Andr?? Weber ◽  
Christoph Thilmann ◽  
Matthias P. Lichy ◽  
Matthias G??nther ◽  
Stefan Delorme ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Dynamic Susceptibility ◽  
Contrast Enhanced

scholarly journals NI-11 Usefulness of the magnetic resonance imaging arterial spin labeling method for diagnosing posterior fossa hemangioblastoma

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi19-vi20
Author(s):  
Takeshi Hiu ◽  
Ayano Ishiyama ◽  
Minoru Morikawa ◽  
Shiro Baba ◽  
Kenta Ujifuku ◽  
...  
Keyword(s):  
Posterior Fossa ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Posterior Fossa Tumors ◽  
Perfusion Image ◽  
Diffusion Weighted Images ◽  
Diffusion Weighted ◽  
Contrast Enhanced

Abstract Purpose: It is sometimes challenging to diagnose hemangioblastoma by MRI when the tumor is a solid mass in the posterior fossa. We therefore evaluated perfusion images and diffusion-weighted images to diagnose hemangioblastoma in order to obtain the most useful quantitative features. Methods: Thirty-one posterior fossa tumors whose pathological diagnosis was confirmed by surgery were included in groups A (12 hemangioblastomas) and B (non-hemangioblastoma 19 cases: metastatic tumor 6 cases, pilocytic astrocytoma 3 cases, malignant lymphoma 3 cases, glioblastoma 2 cases, medulloblastoma 2 cases, and other 3 cases). All cases were imaged by 3.0-Tesla MRI, with the apparent diffusion coefficient (ADC) on diffusion-weighted imaging as the parameter, arterial spin labeling (ASL) as the relative value from the CBF map to the region of interest (ROI) in the contralateral hemisphere as perfusion image, dynamic susceptibility contrast (DSC) as rCBF, rCBV, corrected CBV, and K2. The ROI was set to match the contrast-enhanced part, and the two groups were compared and examined. Results: The relative ASL value of group A and the corrected CBV in DSC were significantly higher than group B (p<0.001). In contrast, the ADC showed no marked difference between the two groups. In the distinction between the two groups, the receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) of the relative ASL value was significantly higher than the other parameters (AUC 0.995, cut-off value 2.34, sensitivity 100%, specificity 99.5%). Discussion/Conclusion: The non-contrast ASL method was extremely useful for diagnosing hemangioblastoma in posterior fossa tumors. The ASL method has been reported helpful for the follow-up of residual tumors or recurrence after surgery. Contrast-enhanced DSC is not always essential for diagnosing posterior fossa hemangioblastoma. It should be noted that measuring the ROI by ASL is difficult when the size of the mural nodule is small.

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