An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways

Key Points Microdeletions represent an additional inactivation mechanism for PTEN in human T-cell acute lymphoblastic leukemia. PTEN microdeletions are RAG-mediated aberrations.

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Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance

Acta Pharmacologica Sinica ◽

10.1038/aps.2013.124 ◽

2013 ◽

Vol 34 (12) ◽

pp. 1545-1553 ◽

Cited By ~ 10

Author(s):

Min Li ◽

Xiang Zhang ◽

Wen-jing Zhou ◽

Yue-hua Chen ◽

Hui Liu ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Hsp90 Inhibitor ◽

Leukemia Cells ◽

Human T Cell ◽

Cell Acute Lymphoblastic Leukemia ◽

Induced Apoptosis

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Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

Leukemia ◽

10.1038/leu.2011.93 ◽

2011 ◽

Vol 25 (8) ◽

pp. 1249-1258 ◽

Cited By ~ 44

Author(s):

B Gerby ◽

E Clappier ◽

F Armstrong ◽

C Deswarte ◽

J Calvo ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Cell Populations ◽

Human T Cell ◽

Cell Acute Lymphoblastic Leukemia

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The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling

Cancer Research ◽

10.1158/0008-5472.can-06-4381 ◽

2007 ◽

Vol 67 (12) ◽

pp. 5611-5616 ◽

Cited By ~ 131

Author(s):

Alena Malyukova ◽

Takeaki Dohda ◽

Natalie von der Lehr ◽

Shahab Akhondi ◽

Martin Corcoran ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Tumor Suppressor ◽

Notch Signaling ◽

Tumor Suppressor Gene ◽

Lymphoblastic Leukemia ◽

Suppressor Gene ◽

Human T Cell ◽

Functional Consequences ◽

Cell Acute Lymphoblastic Leukemia

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Abstract LB-301: Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia

10.1158/1538-7445.am2020-lb-301 ◽

2020 ◽

Author(s):

CHUJING ZHANG ◽

Stella Amanda ◽

Cheng Wang ◽

Tze King Tan ◽

Zulfaqar Ali Muhammad ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Aldehyde Dehydrogenase ◽

Lymphoblastic Leukemia ◽

Cell Acute Lymphoblastic Leukemia

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Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemia

Oncogene ◽

10.1038/s41388-020-01453-2 ◽

2020 ◽

Vol 39 (42) ◽

pp. 6544-6555

Author(s):

Deborah Bongiovanni ◽

Valeria Tosello ◽

Valentina Saccomani ◽

Silvia Dalla Santa ◽

Alberto Amadori ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Combination Therapy ◽

Glucocorticoid Receptor ◽

Lymphoblastic Leukemia ◽

Hedgehog Pathway ◽

Cell Acute Lymphoblastic Leukemia

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Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2010.02.014 ◽

2010 ◽

Vol 320 (1-2) ◽

pp. 76-86 ◽

Cited By ~ 9

Author(s):

Jason R. Schwartz ◽

Purvaba J. Sarvaiya ◽

Wayne V. Vedeckis

Keyword(s):

Gene Regulation ◽

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Glucocorticoid Receptor ◽

B Cell ◽

Lymphoblastic Leukemia ◽

Knock Down ◽

Cell Acute Lymphoblastic Leukemia

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Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF- B and JNK/AP-1 pathways

Haematologica ◽

10.3324/haematol.12098 ◽

2008 ◽

Vol 93 (4) ◽

pp. 524-532 ◽

Cited By ~ 38

Author(s):

M. T. Scupoli ◽

M. Donadelli ◽

F. Cioffi ◽

M. Rossi ◽

O. Perbellini ◽

...

Keyword(s):

Bone Marrow ◽

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Stromal Cells ◽

Bone Marrow Stromal Cells ◽

Lymphoblastic Leukemia ◽

Marrow Stromal Cells ◽

Human T Cell ◽

Cell Acute Lymphoblastic Leukemia ◽

Cxcr4 Axis

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Silencing of Notch3 Using shRNA Driven by Survivin Promoter Inhibits Growth and Promotes Apoptosis of Human T-Cell Acute Lymphoblastic Leukemia Cells

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/j.clml.2011.07.005 ◽

2012 ◽

Vol 12 (1) ◽

pp. 59-65 ◽

Cited By ~ 6

Author(s):

Jie Xiang ◽

Yongri Ouyang ◽

Ying Cui ◽

Fang Lin ◽

Jihong Ren ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Lymphoblastic Leukemia ◽

Leukemia Cells ◽

Survivin Promoter ◽

Human T Cell ◽

Cell Acute Lymphoblastic Leukemia

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Kinetics of early therapeutic response as measured by quantitative PCR predicts survival in a murine xenograft model of human T cell acute lymphoblastic leukemia

Leukemia ◽

10.1038/sj.leu.2401814 ◽

2000 ◽

Vol 14 (7) ◽

pp. 1215-1224 ◽

Cited By ~ 7

Author(s):

GA Hosler ◽

R Bash ◽

RH Scheuermann

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Quantitative Pcr ◽

Therapeutic Response ◽

Lymphoblastic Leukemia ◽

Xenograft Model ◽

Human T Cell ◽

Murine Xenograft Model ◽

Cell Acute Lymphoblastic Leukemia ◽

Kinetics Of

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