scholarly journals Decrease in total protein level of Bruton’s tyrosine kinase during ibrutinib therapy in chronic lymphocytic leukemia lymphocytes

Leukemia ◽  
2016 ◽  
Vol 30 (8) ◽  
pp. 1803-1804 ◽  
Author(s):  
F Cervantes-Gomez ◽  
V Kumar Patel ◽  
P Bose ◽  
M J Keating ◽  
V Gandhi
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
Total Protein ◽  
Protein Level ◽  
Lymphocytic Leukemia ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Total Protein Level

scholarly journals Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1207-1213 ◽  
Author(s):  
Jennifer A. Woyach ◽  
Engin Bojnik ◽  
Amy S. Ruppert ◽  
Matthew R. Stefanovski ◽  
Virginia M. Goettl ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
Tyrosine Kinase ◽  
Lymphocytic Leukemia ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Genetic Inactivation ◽  
Key Points

Key Points Kinase-functional BTK is important in the development and expansion of CLL. Both targeted genetic inactivation of BTK and inhibition of BTK by ibrutinib inhibit the development of CLL in the TCL1 mouse model.

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