scholarly journals Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

2014 ◽  
Vol 20 (3) ◽  
pp. 337-344 ◽  
Author(s):  
M Mattheisen ◽  
J F Samuels ◽  
Y Wang ◽  
B D Greenberg ◽  
A J Fyer ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia

2016 ◽  
Vol 6 (3) ◽  
pp. e768-e768 ◽  
Author(s):  
J Costas ◽  
N Carrera ◽  
P Alonso ◽  
X Gurriarán ◽  
C Segalàs ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Polygenic Risk ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Genome-wide association study of obsessive-compulsive disorder

2012 ◽  
Vol 18 (7) ◽  
pp. 788-798 ◽  
Author(s):  
S E Stewart ◽  
◽  
D Yu ◽  
J M Scharf ◽  
B M Neale ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals Erratum: Genome-wide association study of obsessive-compulsive disorder

2013 ◽  
Vol 18 (7) ◽  
pp. 843-843
Author(s):  
S E Stewart ◽  
◽  
D Yu ◽  
J M Scharf ◽  
B M Neale ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genome Wide

scholarly journals TH57. GENOME-WIDE ASSOCIATION STUDY OF PAEDIATRIC OBSESSIVE-COMPULSIVE BEHAVIORS, THE CORRELATION WITH IMAGING ENDOPHENOTYPES

2021 ◽  
Vol 51 ◽  
pp. e224-e225
Author(s):  
Lilit Antonyan ◽  
S-M Shaheen ◽  
David Rosenberg ◽  
Gregory Hanna ◽  
Paul Arnold
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Genome Wide ◽  
Compulsive Behaviors

scholarly journals 61. GENOME-WIDE ASSOCIATION STUDY OF OBSESSIVE-COMPULSIVE SYMPTOMS AND HOARDING SYMPTOMS IN THE GENERAL POPULATION

2021 ◽  
Vol 51 ◽  
pp. e73-e74
Author(s):  
Nora I. Strom ◽  
Dirk J.A. Smit ◽  
Talisa Silzer ◽  
Conrad Iyegbe ◽  
Mathieu Lemire ◽  
...  
Keyword(s):  
General Population ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Genome Wide

scholarly journals Significant concordance of genetic variation that increases both the risk for obsessive–compulsive disorder and the volumes of the nucleus accumbens and putamen

2018 ◽  
Vol 213 (1) ◽  
pp. 430-436 ◽  
Author(s):  
Derrek P. Hibar ◽  
Joshua W. Cheung ◽  
Sarah E. Medland ◽  
Mary S. Mufford ◽  
Neda Jahanshad ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Obsessive Compulsive Disorder ◽  
Genome Wide Association Study ◽  
Obsessive Compulsive ◽  
Brain Volumes ◽  
Compulsive Disorder ◽  
Subcortical Brain ◽  
Risk Variants ◽  
Genome Wide ◽  
The Relationship

BackgroundMany studies have identified changes in the brain associated with obsessive–compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures.MethodUsing single nucleotide polymorphism effect concordance analysis, we measured genetic overlap between the first genome-wide association study (GWAS) of OCD (1465 participants with OCD, 5557 controls) and recent GWASs of eight subcortical brain volumes (13 171 participants).ResultsWe found evidence of significant positive concordance between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes. When conditioning OCD risk variants on brain volume, variants influencing putamen, amygdala and thalamus volumes were associated with risk for OCD.ConclusionsThese results are consistent with current OCD neurocircuitry models. Further evidence will clarify the relationship between putamen volume and OCD risk, and the roles of the detected variants in this disorder.Declaration of interestThe authors have declared that no competing interests exist.

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