scholarly journals The emerging role of resident memory T cells in protective immunity and inflammatory disease

2015 ◽  
Vol 21 (7) ◽  
pp. 688-697 ◽  
Author(s):  
Chang Ook Park ◽  
Thomas S Kupper
Keyword(s):  
T Cells ◽  
Inflammatory Disease ◽  
Protective Immunity ◽  
Memory T Cells ◽  
Resident Memory T Cells

Pathogenic role of tissue-resident memory T cells in autoimmune diseases

2018 ◽  
Vol 17 (9) ◽  
pp. 906-911 ◽  
Author(s):  
Haijing Wu ◽  
Wei Liao ◽  
Qianwen Li ◽  
Hai Long ◽  
Heng Yin ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Diseases ◽  
Memory T Cells ◽  
Pathogenic Role ◽  
Resident Memory T Cells

scholarly journals CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

2019 ◽  
Vol 216 (12) ◽  
pp. 2748-2762 ◽  
Author(s):  
Alexander N. Wein ◽  
Sean R. McMaster ◽  
Shiki Takamura ◽  
Paul R. Dunbar ◽  
Emily K. Cartwright ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Protective Immunity ◽  
Memory T Cells ◽  
Respiratory Pathogens ◽  
First Line ◽  
Memory Cd8 T Cells ◽  
Effector Functions ◽  
Signaling Axis ◽  
Resident Memory T Cells

Resident memory T cells (TRM cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung TRM cell populations to protective immunity and the factors that govern their localization to different compartments of the lung are not well understood. Here, we show that airway and interstitial TRM cells have distinct effector functions and that CXCR6 controls the partitioning of TRM cells within the lung by recruiting CD8 TRM cells to the airways. The absence of CXCR6 significantly decreases airway CD8 TRM cells due to altered trafficking of CXCR6−/− cells within the lung, and not decreased survival in the airways. CXCL16, the ligand for CXCR6, is localized primarily at the respiratory epithelium, and mice lacking CXCL16 also had decreased CD8 TRM cells in the airways. Finally, blocking CXCL16 inhibited the steady-state maintenance of airway TRM cells. Thus, the CXCR6/CXCL16 signaling axis controls the localization of TRM cells to different compartments of the lung and maintains airway TRM cells.

scholarly journals Memory T Cells in Flavivirus Vaccination

Vaccines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 73 ◽  
Author(s):  
Guangyu Li ◽  
Cody Teleki ◽  
Tian Wang
Keyword(s):  
Clinical Trials ◽  
T Cells ◽  
Animal Models ◽  
Yellow Fever ◽  
Protective Immunity ◽  
Memory T Cells ◽  
Host Protection ◽  
Tick Borne Encephalitis ◽  
Flavivirus Infection

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.

scholarly journals The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?

2020 ◽  
Vol 32 (9) ◽  
pp. 583-587 ◽  
Author(s):  
Changwei Peng ◽  
Stephen C Jameson
Keyword(s):  
T Cells ◽  
Immune System ◽  
Protective Immunity ◽  
Memory T Cells ◽  
Helper T Cells ◽  
Lymphoid Tissues ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Resident Memory T Cells ◽  
The Relationship

Abstract Independent studies over the last decade have characterized the properties of non-circulating CD8+ ‘resident’ memory T cells (TRM), which offer barrier protective immunity in non-lymphoid tissues and CD4+ follicular helper T cells (TFH), which mediate B-cell help in lymphoid sites. Despite their very different biological roles in the immune system, intriguing parallels have been noted between the trafficking properties and differentiation cues of these populations, parallels which have only sharpened with recent findings. In this review, we explore the features that underlie these similarities and discuss whether these indicate meaningful homologies in the development of CD8+ TRM and CD4+ TFH or reflect resemblances which are only ‘skin-deep’.

Emerging role of Tissue Resident Memory T cells in vitiligo: From pathogenesis to therapeutics

2021 ◽  
pp. 102868
Author(s):  
Firdosh Shah ◽  
Shivani Patel ◽  
Rasheedunnisa Begum ◽  
Mitesh Dwivedi
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Resident Memory T Cells

scholarly journals Peripheral Selection of  T Cell Repertoires: The Role of Continuous Thymus Output

1997 ◽  
Vol 186 (7) ◽  
pp. 1099-1106 ◽  
Author(s):  
Corinne Tanchot ◽  
Benedita Rocha
Keyword(s):  
T Cells ◽  
T Cell ◽  
Memory T Cells ◽  
Cell Receptor ◽  
Cell Renewal ◽  
Single Clone ◽  
Transgenic Cells ◽  
Resident Memory T Cells

We investigated the role of continuous thymus output in the shaping of mature T cell repertoires by studying in vivo the survival of a single clone of mature Rag2-deficient T cell receptor (TCR) transgenic cells at different stages of activation in the absence or presence of thymus export. In the absence of thymus export, TCR-transgenic lymphocytes survived indefinitely in the peripheral pools. When new lymphocytes were produced in the thymus and migrated to the periphery, resident memory T cells were maintained in constant numbers, whereas naive and self-reactive T cells were replaced by recent thymus migrants. This T cell renewal ensured both the efficiency of recall responses to antigens as memory T cells persisted independently of thymus output, and the capacity of the immune system to respond to new antigen stimulation as the naive T cell pool was continuously renewed. Our results also indicate that thymus export is required to control the number of self-reactive peripheral T cells that may invade the peripheral pools if thymus output fails.

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