scholarly journals Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

2014 ◽  
Vol 39 (7) ◽  
pp. 1763-1776 ◽  
Author(s):  
Peng Zhong ◽  
Wei Wang ◽  
Bin Pan ◽  
Xiaojie Liu ◽  
Zhen Zhang ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Mtor Signaling ◽  
Monoacylglycerol Lipase ◽  
Lipase Inhibition

scholarly journals Monoacylglycerol lipase inhibition attenuates acute and anticipatory nausea in rats

SURG Journal ◽  
2014 ◽  
Vol 7 (3) ◽  
pp. 21-29
Author(s):  
Rachel I. Downey ◽  
Cheryl L. Limebeer ◽  
Heather I. Morris ◽  
Linda A. Parker
Keyword(s):  
Receptor Antagonist ◽  
Receptor Activation ◽  
Cb1 Receptor ◽  
Monoacylglycerol Lipase ◽  
Anticipatory Nausea ◽  
Acute Nausea ◽  
Sr 141716 ◽  
Cb1 Receptor Antagonist ◽  
Lipase Inhibition

This study investigates the role of the endocannabinoid 2-arachidonyl glycerol (2-AG) in regulating acute and anticipatory nausea in rats using the conditioned gaping model. The animals were systemically pretreated with MJN110, a selective monoacylglycerol lipase (MAGL) inhibitor, to enhance endogenous levels of 2-AG. Acute nausea was assessed using the taste reactivity model in which a flavour, saccharin, was paired with the administration of the emetic agent, lithium chloride (LiCl). Anticipatory nausea was assessed using a model of contextually elicited conditioned gaping in which a context was paired with the emetic agent, LiCl. Results indicated that MJN110 at the 10.0 mg kg-1 and 20.0 mg kg-1 dosage significantly attenuated acute and anticipatory nausea, as displayed by the significant reduction in mean number of gapes. This suppression was mediated by CB1 receptor activation as displayed by reversal of such effects when MJN110 was coadministered with the CB1 receptor antagonist, SR 141716. The results suggest that enhancement of endogenous 2-AG levels by MAGL inhibition may have anti-emetic potential. Keywords: 2-arachidonyl glycerol; monoacylglycerol lipase; endocannabinoid; nausea; conditioned gaping; CB1 receptor

Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model

2020 ◽  
Author(s):  
Jing Wang ◽  
Xiaohua Zhang ◽  
Chongmei Yang ◽  
Shulei Zhao
Keyword(s):  
Tight Junction ◽  
Chronic Stress ◽  
Intestinal Permeability ◽  
Cannabinoid Receptor ◽  
Fluorescein Isothiocyanate ◽  
Control Group ◽  
Monoacylglycerol Lipase ◽  
Associated Proteins ◽  
Cb1 Antagonist ◽  
Novel Target

Abstract Background: The endocannabinoid 2-arachidonoylglycerol (2-AG) is an anti-nociceptive lipid, which is inactivated through cellular uptake and subsequent catabolism by monoacylglycerol lipase (MAGL). The present study aimed to explore the effects of inhibition of MAGL on intestinal permeability. Methods: We first tested it in differentiated CaCO2 cells after 21 days’ culture. The rat model of water avoidance stress (WAS) was established, and rats were divided into four groups according to intervention. Rats received intraperitoneal injection (i.p.) of an MAGL inhibitor (JZL184) alone, JZL184 and the cannabinoid receptor 1 (CB1) antagonist (SR141716A), JZL184 and a cannabinoid receptor 2 (CB2) antagonist (AM630) or vehicle alone (control). We analyzed the fluorescein isothiocyanate-dextran (FD4) permeability and 2-AG level. Expression of MAGL and tight-junction-associated proteins were detected by western blot. Results: Compared with the control group, MAGL expression was higher and 2-AG levels lower among WAS rats. Intestinal permeability was increased following administration of JZL184 which occurred due to up-regulation of tight-junction-associated proteins Claudin-1, Claudin-2, Claudin-5 and Occludin.Conclusion: The effects of MAGL inhibition were mediated by CB1, indicating that MAGL may represent a novel target for the treatment of reduced intestinal permeability in the context of chronic stress.

Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice

2006 ◽  
Vol 211 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Gary B. Quistad ◽  
Rebecka Klintenberg ◽  
Pierluigi Caboni ◽  
Shannon N. Liang ◽  
John E. Casida
Keyword(s):  
Organophosphorus Compounds ◽  
Monoacylglycerol Lipase ◽  
Lipase Inhibition

scholarly journals Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

2016 ◽  
Vol 173 (21) ◽  
pp. 3134-3144 ◽  
Author(s):  
James J Burston ◽  
Paul I Mapp ◽  
Sarir Sarmad ◽  
David A Barrett ◽  
Micah J Niphakis ◽  
...  
Keyword(s):  
Monoacylglycerol Lipase ◽  
Osteoarthritis Pain ◽  
Lipase Inhibition

scholarly journals Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12‐Week, Randomized, Controlled Study

2021 ◽  
Author(s):  
Kirsten R. Müller‐Vahl ◽  
Carolin Fremer ◽  
Chan Beals ◽  
Jelena Ivkovic ◽  
Henrik Loft ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Monoacylglycerol Lipase ◽  
Randomized Controlled ◽  
Lipase Inhibition
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